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How homology search is regulated in cells remains largely unknown. Using genomic and molecular assays to track spatial chromatin organization and early recombination intermediates, we investigated the roles in homology search of two antagonistic regulators of Rad51-ssDNA filaments metabolism in\n                  <jats:italic>S. cerevisiae<\/jats:italic>\n                  : the Rad51 paralogs Rad55-Rad57 and the 3\u2019-5\u2019 ssDNA translocase Srs2. Srs2 promoted the coordinated search between filaments on each DSB ends, inactivated homology search following homology identification, and stimulated the first strand synthesis of BIR. Rad55-Rad57 both stimulated the formation of Rad51-ssDNA filaments and protected them against disruption by Srs2. Together, Rad55-Rad57 and Srs2 enacted a structural proof-reading that resulted in stiffer Rad51-ssDNA filaments competent for genome-wide homology search. This work reveals multiple ways by which the control of Rad51-ssDNA filament metastability by the individual and joint activities of Rad55-Rad57 and Srs2 regulate homology search onset, coordination, reach and inactivation.\n                <\/jats:p>","DOI":"10.64898\/2026.09.15.751666","type":"posted-content","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:10:18Z","timestamp":1789654218000},"source":"Crossref","is-referenced-by-count":0,"title":["Rad55-Rad57 and Srs2 regulate homology search onset, coordination, reach and inactivation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0758-4176","authenticated-orcid":false,"given":"Nicolas","family":"Mendiboure","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, ENS de Lyon, Universit\u00e9 Claude Bernard, CNRS UMR5239, Laboratoire de Biologie et Mod\u00e9lisation de la Cellule, Lyon, 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