{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:04:56Z","timestamp":1790085896261,"version":"4.0.1"},"posted":{"date-parts":[[2026,9,17]]},"group-title":"Genetic and Genomic Medicine","reference-count":106,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"award":["R01 EY030521"],"award-info":[{"award-number":["R01 EY030521"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01 AR057106"],"award-info":[{"award-number":["R01 AR057106"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P01 AR048929"],"award-info":[{"award-number":["P01 AR048929"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01 AR078785-02"],"award-info":[{"award-number":["R01 AR078785-02"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2R01 AR073201"],"award-info":[{"award-number":["2R01 AR073201"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["2P30 AR070253"],"award-info":[{"award-number":["2P30 AR070253"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RC1 AR058587"],"award-info":[{"award-number":["RC1 AR058587"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P30 AR073750"],"award-info":[{"award-number":["P30 AR073750"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["P20 AR070549"],"award-info":[{"award-number":["P20 AR070549"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,17]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>\n                  Juvenile idiopathic arthritis (JIA), the most common class of pediatric rheumatic diseases, can lead to joint damage and extra-articular features including uveitis. Early treatment can improve functional outcomes; but many patients do not respond to first-line treatments. We present a JIA Immunochip-based association analysis of rheumatoid factor-negative polyarticular JIA and oligoarticular JIA. This study spans 3,939 cases and 14,412 controls, including 1,123 cases and 1,356 controls not previously analyzed. We identify 41 (14 novel) JIA risk regions and report a JIA polygenic risk score that also associates with age of onset. Functional mechanisms presented include: a novel interaction between HLA-A*02:01 and\n                  <jats:italic>ERAP2<\/jats:italic>\n                  , cluster-based approach for functional amino acid discovery within HLA-DRB1, and sequence-dependent DNA topology for variant prioritization. We present a comprehensive list of curated gene-drug\/small molecule interactions for clinically focused studies. These findings provide a deepened understanding of the genetics of JIA and potential mechanisms to inform precision medicine.\n                <\/jats:p>","DOI":"10.64898\/2026.09.16.26363161","type":"posted-content","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:55:13Z","timestamp":1789707313000},"source":"Crossref","is-referenced-by-count":0,"title":["Identification and evaluation of 41 risk loci for juvenile idiopathic arthritis informs precision medicine: mechanistic implications of DNA topology and an HLA-A*02:01-ERAP2 interaction"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1185-0695","authenticated-orcid":false,"given":"Hannah C.","family":"Ainsworth","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"},{"name":"Center for Precision Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7797-0767","authenticated-orcid":false,"given":"Ekaterina S.","family":"Khvatkova","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9061-8274","authenticated-orcid":false,"given":"Marc","family":"Sudman","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-8010","authenticated-orcid":false,"given":"Miranda C.","family":"Marion","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1392-9727","authenticated-orcid":false,"given":"John F.","family":"Bohnsack","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-8781","authenticated-orcid":false,"given":"Mary E.","family":"Comeau","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1580-869X","authenticated-orcid":false,"given":"Patrick M.","family":"Gaffney","sequence":"additional","affiliation":[{"name":"Genes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-1298","authenticated-orcid":false,"given":"Johannes-Peter","family":"Haas","sequence":"additional","affiliation":[{"name":"German Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-4902","authenticated-orcid":false,"given":"Timothy D.","family":"Howard","sequence":"additional","affiliation":[{"name":"Center for Precision Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA"},{"name":"Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-9262","authenticated-orcid":false,"given":"Kimme","family":"Hyrich","sequence":"additional","affiliation":[{"name":"Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9574-7355","authenticated-orcid":false,"given":"Judith A.","family":"James","sequence":"additional","affiliation":[{"name":"Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA"},{"name":"Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2126-3702","authenticated-orcid":false,"given":"Peter A.","family":"Nigrovic","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Inflammation and Immunity, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Division of Immunology, Boston Children\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-3928","authenticated-orcid":false,"given":"Ellen B.","family":"Nordal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University Hospital of North Norway, Troms\u00f8, Norway"},{"name":"Research Group for Child and Adolescents Health, Department of Clinical Medicine, UiT The Arctic University of Norway, Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0109-1595","authenticated-orcid":false,"given":"Alan M.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"University of Saskatchewan, Saskatoon, Saskatchewan, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-151X","authenticated-orcid":false,"given":"Marite","family":"Rygg","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Pediatrics, St. Olav\u2019s University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-8497","authenticated-orcid":false,"given":"Samantha L.","family":"Smith","sequence":"additional","affiliation":[{"name":"NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"Centre for Genetics and Genomics Versus Arthritis, The University of Manchester, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1042-3889","authenticated-orcid":false,"given":"Vibeke","family":"Videm","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway"},{"name":"Department of Immunology and Transfusion Medicine, St. Olav\u2019s University Hospital, Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-1429","authenticated-orcid":false,"given":"Lucy R.","family":"Wedderburn","sequence":"additional","affiliation":[{"name":"Infection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK"},{"name":"Centre for Adolescent Rheumatology, UCL Hospital and Great Ormond Street Hospital, London, UK"},{"name":"NIHR Biomedical Research Centre at Great Ormond Street Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-2194","authenticated-orcid":false,"given":"Carol A.","family":"Wise","sequence":"additional","affiliation":[{"name":"McDermott Center for Human Growth and Development, Departments of Orthopedic Surgery and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Center for Translational Research, Scottish Rite Hospital for Children, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2361-725X","authenticated-orcid":false,"given":"Rae S.M.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Cell and Systems Biology Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada"},{"name":"Departments of Pediatrics, Immunology & Medical Science, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-2796","authenticated-orcid":false,"given":"Susan D.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5923-7051","authenticated-orcid":false,"given":"Grant S.","family":"Schulert","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3489-1756","authenticated-orcid":false,"given":"Sampath","family":"Prahalad","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA"},{"name":"Children\u2019s Healthcare of Atlanta Inc., Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4659-031X","authenticated-orcid":false,"given":"John","family":"Bowes","sequence":"additional","affiliation":[{"name":"Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK"},{"name":"NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-6464","authenticated-orcid":false,"given":"Sheila T.","family":"Angeles-Han","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"},{"name":"Division of Ophthalmology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio, USA"},{"name":"Department of Ophthalmology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1878-0717","authenticated-orcid":false,"given":"James N.","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA"},{"name":"Center for Indigenous Health, University of Washington School of Medicine, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4266-6949","authenticated-orcid":false,"given":"Carl D.","family":"Langefeld","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA"},{"name":"Center for Precision Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092206351406000_2026.09.16.26363161v1.1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41572-021-00332-8","article-title":"Juvenile idiopathic arthritis","volume":"8","year":"2022","journal-title":"Nat. Rev. Dis. Primer"},{"key":"2026092206351406000_2026.09.16.26363161v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2013.09.003"},{"key":"2026092206351406000_2026.09.16.26363161v1.3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrrheum.2015.20","article-title":"Uveitis associated with juvenile idiopathic arthritis","volume":"11","year":"2015","journal-title":"Nat. Rev. Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.4","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23871"},{"key":"2026092206351406000_2026.09.16.26363161v1.5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12016-017-8642-3","article-title":"Sex Differences in Pediatric Rheumatology","volume":"56","year":"2019","journal-title":"Clin. Rev. Allergy Immunol"},{"key":"2026092206351406000_2026.09.16.26363161v1.6","doi-asserted-by":"publisher","DOI":"10.1002\/art.27516"},{"key":"2026092206351406000_2026.09.16.26363161v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2614"},{"key":"2026092206351406000_2026.09.16.26363161v1.8","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/art.40216","article-title":"Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci","volume":"69","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210025"},{"key":"2026092206351406000_2026.09.16.26363161v1.10","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/art.40443","article-title":"Brief Report: The Genetic Profile of Rheumatoid Factor\u2013Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis","volume":"70","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.11","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/art.41390","article-title":"New Medications Are Needed for Children With Juvenile Idiopathic Arthritis","volume":"72","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keag402"},{"key":"2026092206351406000_2026.09.16.26363161v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJHG.2022.12.011"},{"key":"2026092206351406000_2026.09.16.26363161v1.14","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.2001.4987"},{"key":"2026092206351406000_2026.09.16.26363161v1.15","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10050"},{"key":"2026092206351406000_2026.09.16.26363161v1.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.008"},{"key":"2026092206351406000_2026.09.16.26363161v1.17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.isci.2019.10.055","article-title":"Deciphering the gene regulatory landscape encoded in DNA biophysical features","volume":"21","year":"2019","journal-title":"Iscience"},{"key":"2026092206351406000_2026.09.16.26363161v1.18","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz970"},{"key":"2026092206351406000_2026.09.16.26363161v1.19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa877"},{"key":"2026092206351406000_2026.09.16.26363161v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2020.103933"},{"key":"2026092206351406000_2026.09.16.26363161v1.21","doi-asserted-by":"crossref","first-page":"102241","DOI":"10.1016\/j.isci.2021.102241","article-title":"Enhancer-associated aortic valve stenosis risk locus 1p21.2 alters NFATC2 binding site and promotes fibrogenesis","volume":"24","year":"2021","journal-title":"iScience"},{"key":"2026092206351406000_2026.09.16.26363161v1.22","doi-asserted-by":"publisher","DOI":"10.1111\/rssb.12388"},{"key":"2026092206351406000_2026.09.16.26363161v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09909-9"},{"key":"2026092206351406000_2026.09.16.26363161v1.24","doi-asserted-by":"publisher","DOI":"10.1002\/art.24601"},{"key":"2026092206351406000_2026.09.16.26363161v1.25","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776"},{"key":"2026092206351406000_2026.09.16.26363161v1.26","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAB1113"},{"key":"2026092206351406000_2026.09.16.26363161v1.27","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab996"},{"key":"2026092206351406000_2026.09.16.26363161v1.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01365-3"},{"key":"2026092206351406000_2026.09.16.26363161v1.29","doi-asserted-by":"publisher","DOI":"10.1186\/1880-6805-33-14"},{"key":"2026092206351406000_2026.09.16.26363161v1.30","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009346"},{"key":"2026092206351406000_2026.09.16.26363161v1.31","doi-asserted-by":"crossref","first-page":"100460","DOI":"10.1016\/j.xgen.2023.100460","article-title":"A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs","volume":"4","year":"2024","journal-title":"Cell Genomics"},{"key":"2026092206351406000_2026.09.16.26363161v1.32","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1093\/hmg\/ddy140","article-title":"A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus","volume":"27","year":"2018","journal-title":"Hum. Mol. Genet"},{"key":"2026092206351406000_2026.09.16.26363161v1.33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033682"},{"key":"2026092206351406000_2026.09.16.26363161v1.34","doi-asserted-by":"publisher","DOI":"10.1186\/ar2347"},{"key":"2026092206351406000_2026.09.16.26363161v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.11.032"},{"key":"2026092206351406000_2026.09.16.26363161v1.36","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab103"},{"key":"2026092206351406000_2026.09.16.26363161v1.37","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1040"},{"key":"2026092206351406000_2026.09.16.26363161v1.38","first-page":"237","article-title":"Physiology and pharmacology of plerixafor. Transfus. Med. Hemotherapy Off. Organ Dtsch. Ges","volume":"40","year":"2013","journal-title":"Transfusionsmedizin Immunhamatologie"},{"key":"2026092206351406000_2026.09.16.26363161v1.39","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2024.0312"},{"key":"2026092206351406000_2026.09.16.26363161v1.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2013.02.008"},{"key":"2026092206351406000_2026.09.16.26363161v1.41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10067-012-2148-4","article-title":"Genistein: the potential for efficacy in rheumatoid arthritis","volume":"32","year":"2013","journal-title":"Clin. Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.42","doi-asserted-by":"crossref","first-page":"917162","DOI":"10.3389\/fphar.2022.917162","article-title":"Advances in Immunosuppressive Agents Based on Signal Pathway","volume":"13","year":"2022","journal-title":"Front. Pharmacol"},{"key":"2026092206351406000_2026.09.16.26363161v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2213"},{"key":"2026092206351406000_2026.09.16.26363161v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16021"},{"key":"2026092206351406000_2026.09.16.26363161v1.45","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41576-025-00869-4","article-title":"Towards improved fine-mapping of candidate causal variants","volume":"26","year":"2025","journal-title":"Nat. Rev. Genet"},{"key":"2026092206351406000_2026.09.16.26363161v1.46","doi-asserted-by":"publisher","DOI":"10.2307\/2289074"},{"key":"2026092206351406000_2026.09.16.26363161v1.47","doi-asserted-by":"publisher","DOI":"10.1126\/science.1193032"},{"key":"2026092206351406000_2026.09.16.26363161v1.48","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.00632.x"},{"key":"2026092206351406000_2026.09.16.26363161v1.49","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/BOR.0000000000000165","article-title":"Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?","volume":"27","year":"2015","journal-title":"Curr. Opin. Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.50","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00307739","article-title":"Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis","volume":"13","year":"1993","journal-title":"Rheumatol. Int"},{"key":"2026092206351406000_2026.09.16.26363161v1.51","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jaut.2016.12.008","article-title":"Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome","volume":"79","year":"2017","journal-title":"J. Autoimmun"},{"key":"2026092206351406000_2026.09.16.26363161v1.52","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100686"},{"key":"2026092206351406000_2026.09.16.26363161v1.53","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2520"},{"key":"2026092206351406000_2026.09.16.26363161v1.54","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M115.048959"},{"key":"2026092206351406000_2026.09.16.26363161v1.55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500721102"},{"key":"2026092206351406000_2026.09.16.26363161v1.56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.685909"},{"key":"2026092206351406000_2026.09.16.26363161v1.57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.molimm.2022.12.010","article-title":"ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes","volume":"154","year":"2023","journal-title":"Mol. Immunol"},{"key":"2026092206351406000_2026.09.16.26363161v1.58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216822110"},{"key":"2026092206351406000_2026.09.16.26363161v1.59","doi-asserted-by":"publisher","DOI":"10.1021\/ar800016q"},{"key":"2026092206351406000_2026.09.16.26363161v1.60","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0209-x"},{"key":"2026092206351406000_2026.09.16.26363161v1.61","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20167238"},{"key":"2026092206351406000_2026.09.16.26363161v1.62","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.4c00202"},{"key":"2026092206351406000_2026.09.16.26363161v1.63","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn198"},{"key":"2026092206351406000_2026.09.16.26363161v1.64","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.2787"},{"key":"2026092206351406000_2026.09.16.26363161v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2614"},{"key":"2026092206351406000_2026.09.16.26363161v1.66","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/art.40443","article-title":"Brief Report: The Genetic Profile of Rheumatoid Factor-Positive Polyarticular Juvenile Idiopathic Arthritis Resembles That of Adult Rheumatoid Arthritis","volume":"70","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.67","first-page":"390","article-title":"International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001","volume":"31","year":"2004","journal-title":"J. Rheumatol."},{"key":"2026092206351406000_2026.09.16.26363161v1.68","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"2026092206351406000_2026.09.16.26363161v1.69","doi-asserted-by":"publisher","DOI":"10.1038\/nature09298"},{"key":"2026092206351406000_2026.09.16.26363161v1.70","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq559"},{"key":"2026092206351406000_2026.09.16.26363161v1.71","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms16021"},{"key":"2026092206351406000_2026.09.16.26363161v1.72","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn288"},{"key":"2026092206351406000_2026.09.16.26363161v1.73","doi-asserted-by":"publisher","DOI":"10.1111\/rssb.12388"},{"key":"2026092206351406000_2026.09.16.26363161v1.74","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05301-4"},{"key":"2026092206351406000_2026.09.16.26363161v1.75","first-page":"3088","article-title":"karyoploteR: an R\/Bioconductor package to plot customizable genomes displaying arbitrary data","volume":"33","year":"2017","journal-title":"Bioinforma. Oxf. Engl"},{"key":"2026092206351406000_2026.09.16.26363161v1.76","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2026092206351406000_2026.09.16.26363161v1.77","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1070"},{"key":"2026092206351406000_2026.09.16.26363161v1.78","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAB1113"},{"key":"2026092206351406000_2026.09.16.26363161v1.79","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab996"},{"key":"2026092206351406000_2026.09.16.26363161v1.80","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq033"},{"key":"2026092206351406000_2026.09.16.26363161v1.81","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAC1052"},{"key":"2026092206351406000_2026.09.16.26363161v1.82","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00157"},{"key":"2026092206351406000_2026.09.16.26363161v1.83","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776"},{"key":"2026092206351406000_2026.09.16.26363161v1.84","doi-asserted-by":"publisher","DOI":"10.1002\/art.24601"},{"key":"2026092206351406000_2026.09.16.26363161v1.85","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01365-3"},{"key":"2026092206351406000_2026.09.16.26363161v1.86","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09909-9"},{"key":"2026092206351406000_2026.09.16.26363161v1.87","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac966"},{"key":"2026092206351406000_2026.09.16.26363161v1.88","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1040"},{"key":"2026092206351406000_2026.09.16.26363161v1.89","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/nrrheum.2015.20","article-title":"Uveitis associated with juvenile idiopathic arthritis","volume":"11","year":"2015","journal-title":"Nat. Rev. Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.90","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv735"},{"key":"2026092206351406000_2026.09.16.26363161v1.91","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa877"},{"key":"2026092206351406000_2026.09.16.26363161v1.92","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1059"},{"key":"2026092206351406000_2026.09.16.26363161v1.93","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2013.18"},{"key":"2026092206351406000_2026.09.16.26363161v1.94","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341X.2001.00632.x"},{"key":"2026092206351406000_2026.09.16.26363161v1.95","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1097\/BOR.0000000000000165","article-title":"Fine-mapping the human leukocyte antigen locus in rheumatoid arthritis and other rheumatic diseases: identifying causal amino acid variants?","volume":"27","year":"2015","journal-title":"Curr. Opin. Rheumatol"},{"key":"2026092206351406000_2026.09.16.26363161v1.96","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp163"},{"key":"2026092206351406000_2026.09.16.26363161v1.97","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae241"},{"key":"2026092206351406000_2026.09.16.26363161v1.98","doi-asserted-by":"publisher","DOI":"10.1111\/2041&ndash;210X.12628"},{"key":"2026092206351406000_2026.09.16.26363161v1.99","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp033"},{"key":"2026092206351406000_2026.09.16.26363161v1.100","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"2026092206351406000_2026.09.16.26363161v1.101","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009346"},{"key":"2026092206351406000_2026.09.16.26363161v1.102","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1074"},{"key":"2026092206351406000_2026.09.16.26363161v1.103","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"2026092206351406000_2026.09.16.26363161v1.104","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-4-2"},{"key":"2026092206351406000_2026.09.16.26363161v1.105","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05225-z"},{"key":"2026092206351406000_2026.09.16.26363161v1.106","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1132"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.16.26363161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:35:27Z","timestamp":1790084127000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.09.16.26363161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,17]]},"references-count":106,"URL":"https:\/\/doi.org\/10.64898\/2026.09.16.26363161","relation":{},"subject":[],"published":{"date-parts":[[2026,9,17]]},"subtype":"preprint"}}