{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:09:15Z","timestamp":1790168955988,"version":"4.1.0"},"posted":{"date-parts":[[2026,9,18]]},"group-title":"Microbiology","reference-count":213,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"South Texas Center for Emerging Infectious Diseases"},{"name":"National Institutes of Health","award":["SC1GM135110"],"award-info":[{"award-number":["SC1GM135110"]}]},{"name":"Ronald E. McNair Scholars Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Plasmids contribute to virulence and antimicrobial resistance in Shiga toxin-producing\n                  <jats:italic>Escherichia coli<\/jats:italic>\n                  (STEC). Here, the mobility, gene content, and evolutionary context of four plasmids carried by an O111:H8 STEC strain designated UTAK-22: pUTAK-22.1-MDR, pUTAK-22.2-MDR, pUTAK-22.3-P1, and pUTAK-22.4-pO111 were characterized. Conjugation experiments, phenotype-based selective readouts, and comparative genomics together showed that pUTAK-22.1-MDR is self-transmissible, whereas pUTAK-22.2-MDR and pUTAK-22.4-pO111 are most consistent with mobilization\n                  <jats:italic>in trans,<\/jats:italic>\n                  making use of the strain\u2019s native helper plasmid background, while pUTAK-22.3-P1 represents a conjugation-deficient IncY phage-derived replicon. Genome annotation and comparative analyses further highlighted the structural diversity and mosaic composition of these plasmids, including P1-like phage remnants, virulence loci, and distinct antimicrobial resistance modules. Phenotypic profiling of the native wild-type plasmid complement and selected transconjugants in the recipient\n                  <jats:italic>E. coli<\/jats:italic>\n                  strain WG5 further showed that the presence of co-resident plasmids and redundant resistance determinants results in dosage-dependent streptomycin tolerance. Together, these findings expand our understanding of the mobility landscape, evolutionary dynamics, and resistance potential of STEC plasmids, while underscoring the importance of interpreting resistance phenotypes in the context of a strain\u2019s natural plasmid composition.\n                <\/jats:p>","DOI":"10.64898\/2026.09.16.752176","type":"posted-content","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:40:10Z","timestamp":1789803610000},"source":"Crossref","is-referenced-by-count":0,"title":["Pathogenome and Plasmid-Borne Antimicrobial Resistance Phenotypes in a Multidrug-Resistant O111:H8 Shiga Toxin-Producing\n                  <i>Escherichia coli<\/i>\n                  Strain"],"prefix":"10.64898","author":[{"given":"Irvin","family":"Rivera","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"},{"name":"South Texas Center for Emerging Infectious Diseases (STCEID), San Antonio, TX, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar A.","family":"Kalalah","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"},{"name":"South Texas Center for Emerging Infectious Diseases (STCEID), San Antonio, TX, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.K.","family":"Koenig","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"},{"name":"South Texas Center for Emerging Infectious Diseases (STCEID), San Antonio, TX, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Sainz Garcia","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob A.","family":"Alford","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando L.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"UT San Antonio, Research Computing Support Group, San Antonio, TX, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Bosilevac","sequence":"additional","affiliation":[{"name":"U.S. Department of Agriculture (USDA), Agricultural Research Service (ARS), U.S. Meat Animal Research Center, Clay Center, NE, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-5219","authenticated-orcid":false,"given":"Mark","family":"Eppinger","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology & Immunology, UT San Antonio, San Antonio, TX, United States"},{"name":"South Texas Center for Emerging Infectious Diseases (STCEID), San Antonio, TX, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092305551279000_2026.09.16.752176v1.1","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2006-508"},{"key":"2026092305551279000_2026.09.16.752176v1.2","first-page":"147","article-title":"Shiga toxin\u2013producing Escherichia coli","volume":"70","year":"2010","journal-title":"Adv Appl Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.3","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-12"},{"key":"2026092305551279000_2026.09.16.752176v1.4","doi-asserted-by":"crossref","first-page":"2672206","DOI":"10.1080\/21505594.2026.2672206","article-title":"Phylogenomic framework and virulence gene boundaries of emerging Shiga toxin-producing Escherichia coli O118 informed by the comprehensive profiling of 359 O118 genomes","volume":"17","year":"2026","journal-title":"Virulence"},{"key":"2026092305551279000_2026.09.16.752176v1.5","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.1.142"},{"key":"2026092305551279000_2026.09.16.752176v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2009.04.011"},{"key":"2026092305551279000_2026.09.16.752176v1.7","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-024-00641-9"},{"key":"2026092305551279000_2026.09.16.752176v1.8","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3390\/microorganisms13071529","article-title":"Shiga Toxin-Producing Escherichia coli (STEC) in Developing Countries: A 10-Year Review with Global Perspective","volume":"13","year":"2025","journal-title":"Microorganisms"},{"key":"2026092305551279000_2026.09.16.752176v1.9","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.8.3282-3288.1994"},{"key":"2026092305551279000_2026.09.16.752176v1.10","doi-asserted-by":"crossref","first-page":"151628","DOI":"10.1016\/j.ijmm.2024.151628","article-title":"Enteroaggregative Escherichia coli: Frequent, yet underdiagnosed pathotype among E. coli O111 strains isolated from children with gastrointestinal disorders in the Czech Republic","volume":"316","year":"2024","journal-title":"Int J Med Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.11","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1364026"},{"key":"2026092305551279000_2026.09.16.752176v1.12","doi-asserted-by":"publisher","DOI":"10.1086\/421781"},{"key":"2026092305551279000_2026.09.16.752176v1.13","doi-asserted-by":"publisher","DOI":"10.1086\/380634"},{"key":"2026092305551279000_2026.09.16.752176v1.14","first-page":"321","article-title":"Escherichia coli O111:H8 outbreak among teenage campers--Texas, 1999","volume":"49","author":"Centers for Disease Control and Prevention","year":"2000","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2026092305551279000_2026.09.16.752176v1.15","doi-asserted-by":"crossref","unstructured":"Parker CT , Huynh S , Bono JL , Miller WG , Cooley MB , Brandl MT . 2019. Complete Genome Sequences of Three Shiga Toxin-Producing Escherichia coli O111:H8 Strains Exhibiting an Aggregation Phenotype. Microbiol Resour Announc 8.","DOI":"10.1128\/MRA.01335-18"},{"key":"2026092305551279000_2026.09.16.752176v1.16","doi-asserted-by":"crossref","unstructured":"Sekizuka T , Lee K , Kimata K , Isobe J , Kuroda M , Iyoda S , Ohnishi M , Sata T , Watahiki M . 2019. Complete Genome Sequence of an Enterohemorrhagic Escherichia coli O111:H8 Strain Recovered from a Large Outbreak in Japan Associated with Consumption of Raw Beef. Microbiol Resour Announc 8.","DOI":"10.1128\/MRA.00882-19"},{"key":"2026092305551279000_2026.09.16.752176v1.17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1186\/s12864-024-10945-4","article-title":"First report and genomic characterization of Escherichia coli O111:H12 serotype from raw mussels in Turkiye","volume":"25","year":"2024","journal-title":"BMC Genomics"},{"key":"2026092305551279000_2026.09.16.752176v1.18","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01229-15"},{"key":"2026092305551279000_2026.09.16.752176v1.19","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00420-14"},{"key":"2026092305551279000_2026.09.16.752176v1.20","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000003"},{"key":"2026092305551279000_2026.09.16.752176v1.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91987-6"},{"key":"2026092305551279000_2026.09.16.752176v1.22","first-page":"80","article-title":"Shiga toxin-converting phages and the emergence of new pathogenic Escherichia coli: a world in motion","volume":"4","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.23","doi-asserted-by":"crossref","first-page":"18777","DOI":"10.1038\/s41598-019-55332-2","article-title":"Transcriptional and Translational Inhibitors Block SOS Response and Shiga Toxin Expression in Enterohemorrhagic Escherichia coli","volume":"9","year":"2019","journal-title":"Scientific Reports"},{"key":"2026092305551279000_2026.09.16.752176v1.24","doi-asserted-by":"crossref","first-page":"888568","DOI":"10.3389\/fcimb.2022.888568","article-title":"Genome Sequence Analysis and Characterization of Shiga Toxin 2 Production by Escherichia coli O157:H7 Strains Associated With a Laboratory Infection","volume":"12","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.25","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00985"},{"key":"2026092305551279000_2026.09.16.752176v1.26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/microorganisms12010140","article-title":"Z3495, a LysR-Type Transcriptional Regulator Encoded in O Island 97, Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli O157:H7","volume":"12","year":"2024","journal-title":"Microorganisms"},{"key":"2026092305551279000_2026.09.16.752176v1.27","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/microorganisms12040687","article-title":"A Comprehensive Review on Shiga Toxin Subtypes and Their Niche-Related Distribution Characteristics in Shiga-Toxin-Producing E. coli and Other Bacterial Hosts","volume":"12","year":"2024","journal-title":"Microorganisms"},{"key":"2026092305551279000_2026.09.16.752176v1.28","doi-asserted-by":"crossref","first-page":"e1014104","DOI":"10.1371\/journal.ppat.1014104","article-title":"Shiga toxin increases intestinal transit to displace resident microbes and facilitate pathogen colonization","volume":"22","year":"2026","journal-title":"PLoS Pathog"},{"key":"2026092305551279000_2026.09.16.752176v1.29","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s42770-024-01269-2","article-title":"Acquisition of plasmids from Shiga toxin-producing Escherichia coli strains had low or neutral fitness cost on commensal E. coli","volume":"55","year":"2024","journal-title":"Braz J Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.30","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00015-09"},{"key":"2026092305551279000_2026.09.16.752176v1.31","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09902-4"},{"key":"2026092305551279000_2026.09.16.752176v1.32","first-page":"e00026","article-title":"Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae","volume":"82","year":"2018","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026092305551279000_2026.09.16.752176v1.33","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3390\/toxins11090502","article-title":"Genetics, Toxicity, and Distribution of Enterohemorrhagic Escherichia coli Hemolysin","volume":"11","year":"2019","journal-title":"Toxins (Basel)"},{"key":"2026092305551279000_2026.09.16.752176v1.34","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01839-16"},{"key":"2026092305551279000_2026.09.16.752176v1.35","doi-asserted-by":"publisher","DOI":"10.1128\/JB.151.3.1290-1298.1982"},{"key":"2026092305551279000_2026.09.16.752176v1.36","doi-asserted-by":"publisher","DOI":"10.1128\/iai.52.1.63-69.1986"},{"key":"2026092305551279000_2026.09.16.752176v1.37","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1128\/iai.58.6.1959-1964.1990","article-title":"Domains of Escherichia coli hemolysin (HlyA) involved in binding of calcium and erythrocyte membranes","volume":"58","year":"1990","journal-title":"Infect Immun"},{"key":"2026092305551279000_2026.09.16.752176v1.38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.3871751.x"},{"key":"2026092305551279000_2026.09.16.752176v1.39","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-142-11-3305"},{"key":"2026092305551279000_2026.09.16.752176v1.40","doi-asserted-by":"publisher","DOI":"10.4161\/viru.24642"},{"key":"2026092305551279000_2026.09.16.752176v1.41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2017.07.004"},{"key":"2026092305551279000_2026.09.16.752176v1.42","first-page":"001454","article-title":"Prevalence of genotypic antimicrobial resistance in clinical Shiga toxin-producing Escherichia coli in Norway, 2018 to 2020","volume":"70","year":"2021","journal-title":"J Med Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.43","first-page":"308","article-title":"Prevalence, Antimicrobial Resistance, and Genotypic Characterization of Diarrheagenic Escherichia coli in Foodborne Diarrhea Cases in Wenzhou Based on Whole-Genome Sequencing","volume":"23","year":"2025","journal-title":"Foodborne Pathog Dis"},{"key":"2026092305551279000_2026.09.16.752176v1.44","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s42770-024-01560-2","article-title":"Pooled prevalence of Escherichia coli phenotypic and genotypic antimicrobial resistance profiles in poultry: systematic review and meta-analysis","volume":"56","year":"2025","journal-title":"Braz J Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.45","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1093\/jac\/dkad231","article-title":"Surveillance of antimicrobial resistant Shiga toxin-producing E. coli O157:H7 in England, 2016-2020","volume":"78","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"2026092305551279000_2026.09.16.752176v1.46","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.00713-22"},{"key":"2026092305551279000_2026.09.16.752176v1.47","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.12.5834-5842.2002"},{"key":"2026092305551279000_2026.09.16.752176v1.48","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.6.2162-2169.2000"},{"key":"2026092305551279000_2026.09.16.752176v1.49","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.6.1604-1607.1998"},{"key":"2026092305551279000_2026.09.16.752176v1.50","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00351-12"},{"key":"2026092305551279000_2026.09.16.752176v1.51","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl127"},{"key":"2026092305551279000_2026.09.16.752176v1.52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00272.x"},{"key":"2026092305551279000_2026.09.16.752176v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2010.09.022"},{"key":"2026092305551279000_2026.09.16.752176v1.54","first-page":"171","article-title":"Virulence Profiling and Molecular Typing of Shiga Toxin-Producing E","volume":"8","year":"2020","journal-title":"Coli (STEC) From Human Sources in Brazil"},{"key":"2026092305551279000_2026.09.16.752176v1.55","doi-asserted-by":"crossref","unstructured":"Duc HM , Ha CTT , Hoa TTK , Hung LV , Thang NV , Son HM . 2024. Prevalence, Molecular Characterization, and Antimicrobial Resistance Profiles of Shiga Toxin-Producing Escherichia coli Isolated from Raw Beef, Pork, and Chicken Meat in Vietnam. Foods 13.","DOI":"10.3390\/foods13132059"},{"key":"2026092305551279000_2026.09.16.752176v1.56","doi-asserted-by":"publisher","DOI":"10.1111\/zph.12533"},{"key":"2026092305551279000_2026.09.16.752176v1.57","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.3201\/eid2309.170523","article-title":"Antimicrobial Drug-Resistant Shiga Toxin-Producing Escherichia coli Infections, Michigan, USA","volume":"23","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"2026092305551279000_2026.09.16.752176v1.58","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msac115"},{"key":"2026092305551279000_2026.09.16.752176v1.59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078862"},{"key":"2026092305551279000_2026.09.16.752176v1.60","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-25"},{"key":"2026092305551279000_2026.09.16.752176v1.61","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107176108"},{"key":"2026092305551279000_2026.09.16.752176v1.62","first-page":"46","article-title":"Implications of free Shiga toxin-converting bacteriophages occurring outside bacteria for the evolution and the detection of Shiga toxin-producing Escherichia coli","volume":"4","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.63","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01108"},{"key":"2026092305551279000_2026.09.16.752176v1.64","doi-asserted-by":"crossref","first-page":"18861","DOI":"10.1038\/s41598-019-54895-4","article-title":"Diversity of P1 phage-like elements in multidrug resistant Escherichia coli","volume":"9","year":"2019","journal-title":"Scientific Reports"},{"key":"2026092305551279000_2026.09.16.752176v1.65","first-page":"459","article-title":"Mobile genetic elements associated with antimicrobial resistance","volume":"16","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.66","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00152-08"},{"key":"2026092305551279000_2026.09.16.752176v1.67","first-page":"5393","article-title":"Plasmids and the spread of resistance","volume":"57","year":"2013","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"2026092305551279000_2026.09.16.752176v1.68","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3390\/antibiotics10030237","article-title":"Antibiotic Resistance in Shiga Toxigenic Escherichia coli Isolates from Surface Waters and Sediments in a Mixed Use Urban Agricultural Landscape","volume":"10","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"2026092305551279000_2026.09.16.752176v1.69","first-page":"20240735","article-title":"Costs of antibiotic resistance genes depend on host strain and environment and can influence community composition","volume":"291","year":"2024","journal-title":"Proc Biol Sci"},{"key":"2026092305551279000_2026.09.16.752176v1.70","doi-asserted-by":"crossref","first-page":"101497","DOI":"10.1016\/j.onehlt.2026.101497","article-title":"Risk ranking and antimicrobial resistance of Shiga toxin-producing Escherichia coli of bovine origin","volume":"23","year":"2026","journal-title":"One Health"},{"key":"2026092305551279000_2026.09.16.752176v1.71","doi-asserted-by":"crossref","first-page":"100288","DOI":"10.1016\/j.jfp.2024.100288","article-title":"Antibiotic Resistance and Disinfectant Resistance Among Escherichia coli Isolated During Red Meat Production","volume":"87","year":"2024","journal-title":"J Food Prot"},{"key":"2026092305551279000_2026.09.16.752176v1.72","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac247"},{"key":"2026092305551279000_2026.09.16.752176v1.73","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0072-8"},{"key":"2026092305551279000_2026.09.16.752176v1.74","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw569"},{"key":"2026092305551279000_2026.09.16.752176v1.75","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5331.1453"},{"key":"2026092305551279000_2026.09.16.752176v1.76","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj405"},{"key":"2026092305551279000_2026.09.16.752176v1.77","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2522"},{"key":"2026092305551279000_2026.09.16.752176v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2009.03.004"},{"key":"2026092305551279000_2026.09.16.752176v1.79","doi-asserted-by":"publisher","DOI":"10.1101\/gr.251678.119"},{"key":"2026092305551279000_2026.09.16.752176v1.80","first-page":"2388","article-title":"Diversity of Non-O157 Shiga Toxin-Producing Escherichia coli Isolated from Cattle from Central and Southern Chile","volume":"11","year":"2021","journal-title":"Animals (Basel)"},{"key":"2026092305551279000_2026.09.16.752176v1.81","doi-asserted-by":"publisher","DOI":"10.1090\/S0002-9939-1956-0078686-7"},{"key":"2026092305551279000_2026.09.16.752176v1.82","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-152"},{"key":"2026092305551279000_2026.09.16.752176v1.83","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-12-402"},{"key":"2026092305551279000_2026.09.16.752176v1.84","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0997-x"},{"key":"2026092305551279000_2026.09.16.752176v1.85","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAB1107"},{"key":"2026092305551279000_2026.09.16.752176v1.86","first-page":"000748","article-title":"ResFinder - an open online resource for identification of antimicrobial resistance genes in next-generation sequencing data and prediction of phenotypes from genotypes","volume":"8","year":"2022","journal-title":"Microb Genom"},{"key":"2026092305551279000_2026.09.16.752176v1.87","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz935"},{"key":"2026092305551279000_2026.09.16.752176v1.88","unstructured":"Seemann T. 2013. barrnap 0.7: rapid ribosomal RNA prediction."},{"key":"2026092305551279000_2026.09.16.752176v1.89","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky425"},{"key":"2026092305551279000_2026.09.16.752176v1.90","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad326"},{"key":"2026092305551279000_2026.09.16.752176v1.91","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30269-9"},{"key":"2026092305551279000_2026.09.16.752176v1.92","unstructured":"Shimoyama Y. 2024. pyGenomeViz: A genome visualization python package for comparative genomics."},{"key":"2026092305551279000_2026.09.16.752176v1.93","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"Seaborn: statistical data visualization","volume":"6","year":"2021","journal-title":"J Open Source Softw"},{"key":"2026092305551279000_2026.09.16.752176v1.94","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad382"},{"key":"2026092305551279000_2026.09.16.752176v1.95","doi-asserted-by":"crossref","first-page":"16663","DOI":"10.1038\/srep16663","article-title":"The Shiga toxin 2 production level in enterohemorrhagic Escherichia coli O157:H7 is correlated with the subtypes of toxin-encoding phage","volume":"5","year":"2015","journal-title":"Scientific Reports"},{"key":"2026092305551279000_2026.09.16.752176v1.96","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.640945"},{"key":"2026092305551279000_2026.09.16.752176v1.97","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08428-5"},{"key":"2026092305551279000_2026.09.16.752176v1.98","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00860-12"},{"key":"2026092305551279000_2026.09.16.752176v1.99","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.739"},{"key":"2026092305551279000_2026.09.16.752176v1.100","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-16-228"},{"key":"2026092305551279000_2026.09.16.752176v1.101","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx343"},{"key":"2026092305551279000_2026.09.16.752176v1.102","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty095"},{"key":"2026092305551279000_2026.09.16.752176v1.103","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bby042"},{"key":"2026092305551279000_2026.09.16.752176v1.104","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-421"},{"key":"2026092305551279000_2026.09.16.752176v1.105","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02060-21"},{"key":"2026092305551279000_2026.09.16.752176v1.106","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj014"},{"key":"2026092305551279000_2026.09.16.752176v1.107","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1123"},{"key":"2026092305551279000_2026.09.16.752176v1.108","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx433"},{"key":"2026092305551279000_2026.09.16.752176v1.109","unstructured":"Eppinger M , Koenig SSK. 2026. PlasmidTyper, v1.0. GitHub. https:\/\/github.com\/kramppe\/PlasmidTyper."},{"key":"2026092305551279000_2026.09.16.752176v1.110","first-page":"000206","article-title":"MOB-suite: software tools for clustering, reconstruction and typing of plasmids from draft assemblies","volume":"4","year":"2018","journal-title":"Microb Genom"},{"key":"2026092305551279000_2026.09.16.752176v1.111","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04299-x"},{"key":"2026092305551279000_2026.09.16.752176v1.112","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1095"},{"key":"2026092305551279000_2026.09.16.752176v1.113","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1050"},{"key":"2026092305551279000_2026.09.16.752176v1.114","first-page":"000728","article-title":"ECTyper: in silico Escherichia coli serotype and species prediction from raw and assembled whole-genome sequence data","volume":"7","year":"2021","journal-title":"Microb Genom"},{"key":"2026092305551279000_2026.09.16.752176v1.115","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky383"},{"key":"2026092305551279000_2026.09.16.752176v1.116","doi-asserted-by":"publisher","DOI":"10.1128\/aem.00991-22"},{"key":"2026092305551279000_2026.09.16.752176v1.117","doi-asserted-by":"crossref","first-page":"700","DOI":"10.3390\/microorganisms10040700","article-title":"IntegronFinder 2.0: Identification and Analysis of Integrons across Bacteria, with a Focus on Antibiotic Resistance in Klebsiella","volume":"10","year":"2022","journal-title":"Microorganisms"},{"key":"2026092305551279000_2026.09.16.752176v1.118","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00213-21"},{"key":"2026092305551279000_2026.09.16.752176v1.119","doi-asserted-by":"crossref","first-page":"102512","DOI":"10.1016\/j.xpro.2023.102512","article-title":"Antimicrobial susceptibility testing to evaluate minimum inhibitory concentration values of clinically relevant antibiotics","volume":"4","year":"2023","journal-title":"STAR Protoc"},{"key":"2026092305551279000_2026.09.16.752176v1.120","doi-asserted-by":"crossref","first-page":"1079033","DOI":"10.3389\/fmicb.2023.1079033","article-title":"Development of a high-throughput minimum inhibitory concentration (HT-MIC) testing workflow","volume":"14","year":"2023","journal-title":"Front Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.121","doi-asserted-by":"crossref","unstructured":"Imamovic L , Misiakou MA , van der Helm E , Panagiotou G , Muniesa M , Sommer MOA. 2018. Complete Genome Sequence of Escherichia coli Strain WG5. Genome Announc 6.","DOI":"10.1128\/genomeA.01403-17"},{"key":"2026092305551279000_2026.09.16.752176v1.122","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/s41564-022-01146-4","article-title":"Mating pair stabilization mediates bacterial conjugation species specificity","volume":"7","year":"2022","journal-title":"Nat Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.123","doi-asserted-by":"publisher","DOI":"10.1007\/s00248-024-02427-7"},{"key":"2026092305551279000_2026.09.16.752176v1.124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000344"},{"key":"2026092305551279000_2026.09.16.752176v1.125","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-296"},{"key":"2026092305551279000_2026.09.16.752176v1.126","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.0908.08007"},{"key":"2026092305551279000_2026.09.16.752176v1.127","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-015-0413-9"},{"key":"2026092305551279000_2026.09.16.752176v1.128","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.5.1783-1791.2005"},{"key":"2026092305551279000_2026.09.16.752176v1.129","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02262-12"},{"key":"2026092305551279000_2026.09.16.752176v1.130","first-page":"000551","article-title":"Phylogenetic context of Shiga toxin-producing Escherichia coli serotype O26:H11 in England","volume":"7","year":"2021","journal-title":"Microb Genom"},{"key":"2026092305551279000_2026.09.16.752176v1.131","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.27632-0"},{"key":"2026092305551279000_2026.09.16.752176v1.132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04113.x"},{"key":"2026092305551279000_2026.09.16.752176v1.133","doi-asserted-by":"publisher","DOI":"10.4161\/viru.24498"},{"key":"2026092305551279000_2026.09.16.752176v1.134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000408"},{"key":"2026092305551279000_2026.09.16.752176v1.135","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.20.7839"},{"key":"2026092305551279000_2026.09.16.752176v1.136","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.5.1664"},{"key":"2026092305551279000_2026.09.16.752176v1.137","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1998.tb13078.x"},{"key":"2026092305551279000_2026.09.16.752176v1.138","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00480-08"},{"key":"2026092305551279000_2026.09.16.752176v1.139","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03661-12"},{"key":"2026092305551279000_2026.09.16.752176v1.140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2004.06.024"},{"key":"2026092305551279000_2026.09.16.752176v1.141","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.896296"},{"key":"2026092305551279000_2026.09.16.752176v1.142","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-018-0271-8"},{"key":"2026092305551279000_2026.09.16.752176v1.143","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903585106"},{"key":"2026092305551279000_2026.09.16.752176v1.144","doi-asserted-by":"crossref","unstructured":"Furniss RCD , Clements A . 2018. Regulation of the Locus of Enterocyte Effacement in Attaching and Effacing Pathogens. J Bacteriol 200.","DOI":"10.1128\/JB.00336-17"},{"key":"2026092305551279000_2026.09.16.752176v1.145","first-page":"e65855","article-title":"Multi Locus VNTR (MLVA) Typing and Detection of the OI-122 Pathogenicity Island in Typical and Atypical Enteropathogenic Escherichia coli Isolated from Children with Acute Diarrhea","volume":"14","year":"2019","journal-title":"Arch Clin Infect Dis"},{"key":"2026092305551279000_2026.09.16.752176v1.146","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"2026092305551279000_2026.09.16.752176v1.147","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00189-09"},{"key":"2026092305551279000_2026.09.16.752176v1.148","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq347"},{"key":"2026092305551279000_2026.09.16.752176v1.149","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023415"},{"key":"2026092305551279000_2026.09.16.752176v1.150","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02573-14"},{"key":"2026092305551279000_2026.09.16.752176v1.151","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.3389\/fmicb.2019.02384","article-title":"Successful Host Adaptation of IncK2 Plasmids","volume":"10","year":"2019","journal-title":"Front Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.152","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00407"},{"key":"2026092305551279000_2026.09.16.752176v1.153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010773"},{"key":"2026092305551279000_2026.09.16.752176v1.154","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1147"},{"key":"2026092305551279000_2026.09.16.752176v1.155","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3389\/fmicb.2019.00048","article-title":"Replicon-Based Typing of IncI-Complex Plasmids, and Comparative Genomics Analysis of IncIgamma\/K1 Plasmids","volume":"10","year":"2019","journal-title":"Front Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.156","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17278-2"},{"key":"2026092305551279000_2026.09.16.752176v1.157","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012754"},{"key":"2026092305551279000_2026.09.16.752176v1.158","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00004"},{"key":"2026092305551279000_2026.09.16.752176v1.159","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00056-13"},{"key":"2026092305551279000_2026.09.16.752176v1.160","first-page":"370","article-title":"Resistance integrons; A Mini review","volume":"10","year":"2019","journal-title":"Caspian J Intern Med"},{"key":"2026092305551279000_2026.09.16.752176v1.161","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1462"},{"key":"2026092305551279000_2026.09.16.752176v1.162","doi-asserted-by":"crossref","unstructured":"Fonseca EL , Vicente AC . 2022. Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation. Microorganisms 10.","DOI":"10.3390\/microorganisms10020224"},{"key":"2026092305551279000_2026.09.16.752176v1.163","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"2026092305551279000_2026.09.16.752176v1.164","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2020.102489"},{"key":"2026092305551279000_2026.09.16.752176v1.165","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.8.3638-3646.1987"},{"key":"2026092305551279000_2026.09.16.752176v1.166","doi-asserted-by":"crossref","first-page":"2563018","DOI":"10.1080\/21505594.2025.2563018","article-title":"Enterobactin: A key player in bacterial iron acquisition and virulence and its implications for vaccine development and antimicrobial strategies","volume":"16","year":"2025","journal-title":"Virulence"},{"key":"2026092305551279000_2026.09.16.752176v1.167","doi-asserted-by":"crossref","unstructured":"Sheldon JR , Laakso HA , Heinrichs DE . 2016. Iron Acquisition Strategies of Bacterial Pathogens. Microbiol Spectr 4.","DOI":"10.1128\/microbiolspec.VMBF-0010-2015"},{"key":"2026092305551279000_2026.09.16.752176v1.168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05172.x"},{"key":"2026092305551279000_2026.09.16.752176v1.169","first-page":"607","article-title":"ISCR elements: Novel gene-capturing systems of the 21st century?","volume":"75","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026092305551279000_2026.09.16.752176v1.170","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.54.1.641"},{"key":"2026092305551279000_2026.09.16.752176v1.171","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2009.0037"},{"key":"2026092305551279000_2026.09.16.752176v1.172","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032911"},{"key":"2026092305551279000_2026.09.16.752176v1.173","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2006\/001917-0"},{"key":"2026092305551279000_2026.09.16.752176v1.174","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12866-025-03760-8","article-title":"Insights into incompatible plasmids in multidrug-resistant Raoultella superbugs","volume":"25","year":"2025","journal-title":"BMC Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.175","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02832-10"},{"key":"2026092305551279000_2026.09.16.752176v1.176","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks251"},{"key":"2026092305551279000_2026.09.16.752176v1.177","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.580960"},{"key":"2026092305551279000_2026.09.16.752176v1.178","doi-asserted-by":"crossref","first-page":"e0050823","DOI":"10.1128\/msystems.00508-23","article-title":"The origin and evolution of IncF33 plasmids based on large-scale data sets","volume":"8","year":"2023","journal-title":"mSystems"},{"key":"2026092305551279000_2026.09.16.752176v1.179","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01707-08"},{"key":"2026092305551279000_2026.09.16.752176v1.180","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1128\/jcm.34.10.2364-2367.1996","article-title":"Enterohemolytic phenotypes and genotypes of shiga toxin-producing Escherichia coli O111 strains from patients with diarrhea and hemolytic-uremic syndrome","volume":"34","year":"1996","journal-title":"J Clin Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.181","first-page":"3332","article-title":"Origin of the Mobile Di-Hydro-Pteroate Synthase Gene Determining Sulfonamide Resistance in Clinical Isolates","volume":"9","year":"2018","journal-title":"Front Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.182","doi-asserted-by":"publisher","DOI":"10.1038\/s41396-022-01329-1"},{"key":"2026092305551279000_2026.09.16.752176v1.183","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2013.05.030"},{"key":"2026092305551279000_2026.09.16.752176v1.184","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604891103"},{"key":"2026092305551279000_2026.09.16.752176v1.185","doi-asserted-by":"crossref","first-page":"gkaf652","DOI":"10.1093\/nar\/gkaf652","article-title":"The extended mobility of plasmids","volume":"53","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026092305551279000_2026.09.16.752176v1.186","doi-asserted-by":"crossref","first-page":"e0141022","DOI":"10.1128\/spectrum.01410-22","article-title":"Similarities of P1-Like Phage Plasmids and Their Role in the Dissemination of bla(CTX-M-55)","volume":"10","year":"2022","journal-title":"Microbiol Spectr"},{"key":"2026092305551279000_2026.09.16.752176v1.187","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45757-3"},{"key":"2026092305551279000_2026.09.16.752176v1.188","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.21.7032-7068.2004"},{"key":"2026092305551279000_2026.09.16.752176v1.189","first-page":"668113","article-title":"P1-like bacteriophage-plasmids are important vehicles mediating the dissemination of multidrug resistance genes in Escherichia coli","volume":"12","year":"2021","journal-title":"Front Microbiol"},{"key":"2026092305551279000_2026.09.16.752176v1.190","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1235"},{"key":"2026092305551279000_2026.09.16.752176v1.191","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00020-10"},{"key":"2026092305551279000_2026.09.16.752176v1.192","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1128\/iai.35.2.654-659.1982","article-title":"Further characterization of complement resistance conferred on Escherichia coli by the plasmid genes traT of R100 and iss of ColV,I-K94","volume":"35","year":"1982","journal-title":"Infect Immun"},{"key":"2026092305551279000_2026.09.16.752176v1.193","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01395-08"},{"key":"2026092305551279000_2026.09.16.752176v1.194","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03728-14"},{"key":"2026092305551279000_2026.09.16.752176v1.195","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2003.1364"},{"key":"2026092305551279000_2026.09.16.752176v1.196","unstructured":"Kornberg A , Baker TA . 1992. DNA Replication, 2nd ed."},{"key":"2026092305551279000_2026.09.16.752176v1.197","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2008.02.012"},{"key":"2026092305551279000_2026.09.16.752176v1.198","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S390765"},{"key":"2026092305551279000_2026.09.16.752176v1.199","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.10.2074"},{"key":"2026092305551279000_2026.09.16.752176v1.200","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(88)90429-5"},{"key":"2026092305551279000_2026.09.16.752176v1.201","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.5.1172"},{"key":"2026092305551279000_2026.09.16.752176v1.202","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39778-7"},{"key":"2026092305551279000_2026.09.16.752176v1.203","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.5.599"},{"key":"2026092305551279000_2026.09.16.752176v1.204","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.18.5052-5058.2000"},{"key":"2026092305551279000_2026.09.16.752176v1.205","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2017.03.007"},{"key":"2026092305551279000_2026.09.16.752176v1.206","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.9.3030-3033.2003"},{"key":"2026092305551279000_2026.09.16.752176v1.207","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2965-2971.2005"},{"key":"2026092305551279000_2026.09.16.752176v1.208","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2000.tb09277.x"},{"key":"2026092305551279000_2026.09.16.752176v1.209","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(94)00721-4"},{"key":"2026092305551279000_2026.09.16.752176v1.210","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02625-14"},{"key":"2026092305551279000_2026.09.16.752176v1.211","doi-asserted-by":"publisher","DOI":"10.1099\/13500872-145-5-1005"},{"key":"2026092305551279000_2026.09.16.752176v1.212","first-page":"Doc04","article-title":"Antibiotic therapy in Shiga toxin producing Escherichia coli infection and colonization","volume":"1","year":"2013","journal-title":"GMS Infect Dis"},{"key":"2026092305551279000_2026.09.16.752176v1.213","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.264"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.16.752176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:55:37Z","timestamp":1790168137000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.09.16.752176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":213,"URL":"https:\/\/doi.org\/10.64898\/2026.09.16.752176","relation":{},"subject":[],"published":{"date-parts":[[2026,9,18]]},"subtype":"preprint"}}