{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:20:20Z","timestamp":1792790420595,"version":"4.5.0"},"posted":{"date-parts":[[2026,9,21]]},"group-title":"Genetics","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Mental Health","award":["R01MH120642"],"award-info":[{"award-number":["R01MH120642"]}]},{"name":"National Institute of Mental Health","award":["U01MH125047"],"award-info":[{"award-number":["U01MH125047"]}]},{"name":"National Institute of Mental Health","award":["U01MH125045"],"award-info":[{"award-number":["U01MH125045"]}]},{"name":"National Institute of Mental Health","award":["R01MH112904"],"award-info":[{"award-number":["R01MH112904"]}]},{"name":"National Institute of Mental Health","award":["K08MH118577"],"award-info":[{"award-number":["K08MH118577"]}]},{"name":"National Institute of Mental Health","award":["R01MH077139"],"award-info":[{"award-number":["R01MH077139"]}]},{"name":"Medical Research Council","award":["MR\/Y004094\/1"],"award-info":[{"award-number":["MR\/Y004094\/1"]}]},{"name":"Medical Research Council","award":["MR\/P005748\/1"],"award-info":[{"award-number":["MR\/P005748\/1"]}]},{"name":"Medical Research Council UK","award":["MR\/L010305\/1"],"award-info":[{"award-number":["MR\/L010305\/1"]}],"id":[{"id":"https:\/\/ror.org\/03x94j517","id-type":"ROR","asserted-by":"crossref"}]},{"name":"UKRI Future Leaders Fellowship","award":["MR\/Y033922\/1"],"award-info":[{"award-number":["MR\/Y033922\/1"]}]},{"name":"Medical Research Council (MRC), Brain and Genomics Hub","award":["MR\/Z503745\/1"],"award-info":[{"award-number":["MR\/Z503745\/1"]}]},{"name":"UKRI, Mental Health Goals Omics Project","award":["UKRI3712"],"award-info":[{"award-number":["UKRI3712"]}]},{"name":"Swedish Research Council","id":[{"id":"https:\/\/ror.org\/03zttf063","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["K01DK114379"],"award-info":[{"award-number":["K01DK114379"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Diabetes and Digestive and Kidney Diseases","award":["R01DK129364"],"award-info":[{"award-number":["R01DK129364"]}],"id":[{"id":"https:\/\/ror.org\/00adh9b73","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Stanley Center for Psychiatric Research","id":[{"id":"https:\/\/ror.org\/01tm9b530","id-type":"ROR","asserted-by":"crossref"}]},{"name":"BD2: Breakthrough Discoveries for Thriving with Bipolar Disorder","id":[{"id":"https:\/\/ror.org\/00z5dw933","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Brazilian Coordination for the Improvement of Higher Education Personnel"},{"name":"Merkin Institute"},{"name":"Swiss National Science Foundation","award":["P500-3_235131"],"award-info":[{"award-number":["P500-3_235131"]}],"id":[{"id":"https:\/\/ror.org\/00yjd3n13","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  In this study, we present the largest rare coding variant association study of schizophrenia to date, with 87,959 schizophrenia cases and 150,587 controls. We identify 16 genes at exome-wide significance:\n                  <jats:italic>SETD1A, ZMYM2, HERC1, RB1CC1, SCAF1, XPO7, SP4, FYN, PPP3CA, CUL1, HDAC9, JARID2, ATP9A, PTK2, STAG1,<\/jats:italic>\n                  and\n                  <jats:italic>SCN2A,<\/jats:italic>\n                  and an additional 24 at a 5% false discovery rate. Cases carrying ultra-rare, damaging variants, primarily protein-truncating and deleterious missense mutations, show strong enrichment in constrained genes with consistent effects across ancestries. Half of the 40 identified genes overlap with those implicated in developmental delay, autism, or bipolar disorder, underscoring shared neurodevelopmental risk. All 40 genes identified are highly expressed in excitatory and inhibitory neurons, and their expression patterns span diverse developmental stages. Functionally, the identified genes implicate chromatin regulation, protein degradation, and synaptic function. Overall, our results advance understanding of the genetic architecture of schizophrenia, provide a foundation for modeling risk genes in cellular and animal systems, and offer a framework for future work toward biologically informed patient stratification.\n                <\/jats:p>","DOI":"10.64898\/2026.09.18.752670","type":"posted-content","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:30:24Z","timestamp":1790015424000},"source":"Crossref","is-referenced-by-count":1,"title":["Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia"],"prefix":"10.64898","author":[{"given":"Julia M.","family":"Sealock","sequence":"first","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor","family":"Dowd","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calwing","family":"Liao","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Ye","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Howrigan","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Kyle","family":"Satterstrom","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Auwerx","sequence":"additional","affiliation":[{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Huai","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"He","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melkam","family":"Alemayehu","sequence":"additional","affiliation":[{"name":"Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Gichuru","sequence":"additional","affiliation":[{"name":"Aga Khan University Medical College, East Africa, Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehema M.","family":"Mwende","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute, Aga Khan University, Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.J.C.","family":"Newton","sequence":"additional","affiliation":[{"name":"Kenya Medical Research Institute (KEMRI), Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastassja","family":"Koen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zukiswa","family":"Zingela","sequence":"additional","affiliation":[{"name":"Nelson Mandela University, Gqeberha, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kyebuzibwa","sequence":"additional","affiliation":[{"name":"Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsalan","family":"Hassan","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasue","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Shizuoka Graduate University of Public Health, Shizuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanari","family":"Itokawa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Ayola","family":"Serrano","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Psiqui\u00e1trica CEMIC, Cartagena, Bol\u00edvar, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie E.","family":"Bearden","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"},{"name":"Department of Psychology, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sintia I.","family":"Belangero","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Graduate Program of Functional and Structural Biology, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo G.","family":"Castor Albuquerque","sequence":"additional","affiliation":[{"name":"Hospital de Sa\u00fade Mental Professor Frota Pinto, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Crossley","sequence":"additional","affiliation":[{"name":"Research Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre L.","family":"de Souza Rodrigues","sequence":"additional","affiliation":[{"name":"Genetics and Molecular Biology Graduate Program, Federal University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"},{"name":"Department of Specialized Health, State University of Par\u00e1, Bel\u00e9m, Par\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Diaz-Zuluaga","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateus M.","family":"Diniz","sequence":"additional","affiliation":[{"name":"Pax Cl\u00ednica Instituto de Psiquiatria, Aparecida de Goi\u00e2nia, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago H.","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"School of Medicine, Universidade de Fortaleza (UNIFOR), Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ary","family":"Gadelha","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Paulista School of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Gomez-Makhinson","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayana","family":"Holanda","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Laboratory, Drug Research and Development Center, Department of Physiology and Pharmacology, Federal University of Cear\u00e1, Fortaleza, Cear\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Kopelowicz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro G.","family":"Lorencetti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Paulista School of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas C.","family":"Quarantini","sequence":"additional","affiliation":[{"name":"Department of Neurology and Psychiatry, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Ramirez-Diaz","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor I.","family":"Reus","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, School of Medicine, University of California, San Francisco, San Francisco, California, USA"},{"name":"Laboratory of Neuropsychopharmacology, Psychiatry Service, Universidade Federal da Bahia, Salvador, Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos L.","family":"Santoro","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Paulista School of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Disciplina de Biologia Molecular, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Teshiba","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ziebold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Esteban","family":"Sotelo-Ramirez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Sanabrais-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Phi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope A.","family":"Lind","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Washington, Seattle, Washington, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeniran","family":"Okewole","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney C.P.","family":"Go","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Birmingham, Alabama, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Gur","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Gur","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Craddock","sequence":"additional","affiliation":[{"name":"Cardiff University, Cardiff, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarno","family":"Palotie","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland"},{"name":"Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"H\u00e4m\u00e4l\u00e4inen","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Pietil\u00e4inen","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Glatt","sequence":"additional","affiliation":[{"name":"Upstate Medical University, Syracuse, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hultman","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Arango","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Hospital Universitario La Paz, IdiPAZ, Madrid, Spain"},{"name":"School of Medicine, Universidad Aut\u00f3noma de Madrid, CIBERSAM, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McQuillin","sequence":"additional","affiliation":[{"name":"University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Bass","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann E.","family":"Pulver","sequence":"additional","affiliation":[{"name":"School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"St. Clair","sequence":"additional","affiliation":[{"name":"University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Cohen","sequence":"additional","affiliation":[{"name":"McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas H.","family":"Blackwood","sequence":"additional","affiliation":[{"name":"University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McIntosh","sequence":"additional","affiliation":[{"name":"University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f5nu","family":"Esko","sequence":"additional","affiliation":[{"name":"University of Tartu, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Karlson","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Mass General Brigham (MGB), Brigham and Women\u2019s Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiden P.","family":"Corvin","sequence":"additional","affiliation":[{"name":"Trinity College Dublin, Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek W.","family":"Morris","sequence":"additional","affiliation":[{"name":"University of Galway, Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara","family":"Manoach","sequence":"additional","affiliation":[{"name":"Mass General Research Institute, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Landen","sequence":"additional","affiliation":[{"name":"Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"SCHEMA Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boehnke","sequence":"additional","affiliation":[{"name":"University of Michigan School of Public Health, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders D.","family":"B\u00f8rglum","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Aarhus University, Aarhus, Denmark"},{"name":"The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark"},{"name":"Center for Genomics and Personalized Medicine, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Churchhouse","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Curtis","sequence":"additional","affiliation":[{"name":"UCL Genetics Institute, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"O\u2019Donovan","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Owen","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott","family":"Rees","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick F.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Stockholm, Sweden"},{"name":"University of North Carolina, Chapel Hill, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marquis P.","family":"Vawter","sequence":"additional","affiliation":[{"name":"University of California, Irvine, Irvine, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.R.","family":"Walters","sequence":"additional","affiliation":[{"name":"MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, Wales, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Scott","sequence":"additional","affiliation":[{"name":"University of Michigan School of Public Health, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Medland","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Tuan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Minh Tam","family":"Ta","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam"},{"name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Camarena","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Psiquiatr\u00eda Ram\u00f3n de la Fuente Mu\u00f1iz, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Freimer","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lopez-Jaramillo","sequence":"additional","affiliation":[{"name":"Research Group in Psychiatry, Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"},{"name":"Department of Psychiatry, School of Medicine, Universidad de Antioquia, Medell\u00edn, Antioquia, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loes","family":"Olde Loohuis","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"},{"name":"Department of Computational Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"},{"name":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roel A.","family":"Ophoff","sequence":"additional","affiliation":[{"name":"Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Sawa","sequence":"additional","affiliation":[{"name":"Johns Hopkins Schizophrenia Center and Johns Hopkins iMIND, Department of Psychiatry, Neuroscience, Biomedical Engineering, Pharmacology, Genetic Medicine, and Mental Health, Johns Hopkins University School of Medicine and Bloomberg School of Public Health, Baltimore, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos N.","family":"Pato","sequence":"additional","affiliation":[{"name":"Rutgers University, New Brunswick, New Jersey, USA"},{"name":"BD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.","family":"Pato","sequence":"additional","affiliation":[{"name":"Rutgers University, New Brunswick, New Jersey, USA"},{"name":"BD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ayub","sequence":"additional","affiliation":[{"name":"Division of Psychiatry, University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Rutgers University, New Brunswick, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Rocky","family":"Stroud","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukoye","family":"Atwoli","sequence":"additional","affiliation":[{"name":"Brain and Mind Institute, Aga Khan University, Nairobi, Kenya"},{"name":"Department of Medicine, Aga Khan University Medical College East Africa, Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akena","family":"Dickens","sequence":"additional","affiliation":[{"name":"Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Symon M.","family":"Kariuki","sequence":"additional","affiliation":[{"name":"African Population and Health Research Center, Nairobi, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karestan C.","family":"Koenen","sequence":"additional","affiliation":[{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Department of Social and Behavioral Sciences, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J.","family":"Stein","sequence":"additional","affiliation":[{"name":"South African Medical Research Council (SAMRC) Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Teferra","sequence":"additional","affiliation":[{"name":"Addis Ababa University, Addis Ababa, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengying","family":"Qin","sequence":"additional","affiliation":[{"name":"Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Daly","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Institute for Molecular Medicine Finland, FIMM, HiLIFE, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailiang","family":"Huang","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"BD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Neale","sequence":"additional","affiliation":[{"name":"Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA"},{"name":"Stanley Center for Psychiatric Research, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"},{"name":"BD2: Breakthrough Discoveries for Thriving with Bipolar Disorder, Santa Monica, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092408000872000_2026.09.18.752670v1.1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/jamapsychiatry.2019.3360","article-title":"Schizophrenia\u2014An Overview","volume":"77","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"2026092408000872000_2026.09.18.752670v1.2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.187.1.9"},{"key":"2026092408000872000_2026.09.18.752670v1.3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S2215-0366(17)30078-0","article-title":"Years of potential life lost and life expectancy in schizophrenia: a systematic review and meta-analysis","volume":"4","year":"2017","journal-title":"Lancet Psychiatry"},{"key":"2026092408000872000_2026.09.18.752670v1.4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41586-025-10000-6","article-title":"Biological insights into schizophrenia from ancestrally diverse populations","volume":"651","year":"2026","journal-title":"Nature"},{"key":"2026092408000872000_2026.09.18.752670v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02293-8"},{"key":"2026092408000872000_2026.09.18.752670v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04556-w"},{"key":"2026092408000872000_2026.09.18.752670v1.7","doi-asserted-by":"crossref","unstructured":"Zuk, O. et al. Searching for missing heritability: Designing rare variant association studies. Proc. Natl. Acad. Sci. 111, (2014).","DOI":"10.1073\/pnas.1322563111"},{"key":"2026092408000872000_2026.09.18.752670v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2308-7"},{"key":"2026092408000872000_2026.09.18.752670v1.9","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.11.588920"},{"key":"2026092408000872000_2026.09.18.752670v1.10","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.11.23299809"},{"key":"2026092408000872000_2026.09.18.752670v1.11","doi-asserted-by":"publisher","DOI":"10.1126\/science.adg7492"},{"key":"2026092408000872000_2026.09.18.752670v1.12","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01305-1"},{"key":"2026092408000872000_2026.09.18.752670v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62429-y"},{"key":"2026092408000872000_2026.09.18.752670v1.14","doi-asserted-by":"crossref","first-page":"107510","DOI":"10.1016\/j.phrs.2024.107510","article-title":"IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia","volume":"210","year":"2024","journal-title":"Pharmacol. Res"},{"key":"2026092408000872000_2026.09.18.752670v1.15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/YPG.0000000000000318","article-title":"Clinical features of UK Biobank subjects carrying protein-truncating variants in genes implicated in schizophrenia pathogenesis","volume":"32","year":"2022","journal-title":"Psychiatr. Genet"},{"key":"2026092408000872000_2026.09.18.752670v1.16","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2832-5"},{"key":"2026092408000872000_2026.09.18.752670v1.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.12.036"},{"key":"2026092408000872000_2026.09.18.752670v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/S41586-022-04434-5"},{"key":"2026092408000872000_2026.09.18.752670v1.19","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4399"},{"key":"2026092408000872000_2026.09.18.752670v1.20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01261-5"},{"key":"2026092408000872000_2026.09.18.752670v1.21","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi5199"},{"key":"2026092408000872000_2026.09.18.752670v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/nature10523"},{"key":"2026092408000872000_2026.09.18.752670v1.23","doi-asserted-by":"crossref","unstructured":"Wang, S. et al. SETD1A Mediated H3K4 Methylation and Its Role in Neurodevelopmental and Neuropsychiatric Disorders. Front. Mol. Neurosci. 14, (2021).","DOI":"10.3389\/fnmol.2021.772000"},{"key":"2026092408000872000_2026.09.18.752670v1.24","doi-asserted-by":"crossref","first-page":"RP86669","DOI":"10.7554\/eLife.86669","article-title":"ZMYM2 controls human transposable element transcription through distinct co-regulatory complexes","volume":"12","year":"2023","journal-title":"eLife"},{"key":"2026092408000872000_2026.09.18.752670v1.25","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12657"},{"key":"2026092408000872000_2026.09.18.752670v1.26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70610-0"},{"key":"2026092408000872000_2026.09.18.752670v1.27","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-4-220"},{"key":"2026092408000872000_2026.09.18.752670v1.28","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-021-00626-9"},{"key":"2026092408000872000_2026.09.18.752670v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.10.004"},{"key":"2026092408000872000_2026.09.18.752670v1.30","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba7509"},{"key":"2026092408000872000_2026.09.18.752670v1.31","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-024-01255-0"},{"key":"2026092408000872000_2026.09.18.752670v1.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2020.02.024"},{"key":"2026092408000872000_2026.09.18.752670v1.33","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201712013"},{"key":"2026092408000872000_2026.09.18.752670v1.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68970-8"},{"key":"2026092408000872000_2026.09.18.752670v1.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2004.10.006"},{"key":"2026092408000872000_2026.09.18.752670v1.36","doi-asserted-by":"crossref","unstructured":"Peng, S. & Fu, Y . FYN: emerging biological roles and potential therapeutic targets in cancer. J. Transl. Med. 21, 84 (2023).","DOI":"10.1186\/s12967-023-03930-0"},{"key":"2026092408000872000_2026.09.18.752670v1.37","doi-asserted-by":"crossref","unstructured":"Feng, A. et al. PTK2-associated gene signature could predict the prognosis of IPF. Respir. Res. 24, 304 (2023).","DOI":"10.1186\/s12931-023-02582-4"},{"key":"2026092408000872000_2026.09.18.752670v1.38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.013"},{"key":"2026092408000872000_2026.09.18.752670v1.39","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy052"},{"key":"2026092408000872000_2026.09.18.752670v1.40","doi-asserted-by":"publisher","DOI":"10.1155\/humu\/7085599"},{"key":"2026092408000872000_2026.09.18.752670v1.41","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2021-107843"},{"key":"2026092408000872000_2026.09.18.752670v1.42","doi-asserted-by":"crossref","unstructured":"Yi, F. et al. Regulation of RB1CC1\/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region. Autophagy 19, 1662\u20131677.","DOI":"10.1080\/15548627.2022.2148432"},{"key":"2026092408000872000_2026.09.18.752670v1.43","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKAD347"},{"key":"2026092408000872000_2026.09.18.752670v1.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03279-4"},{"key":"2026092408000872000_2026.09.18.752670v1.45","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/sj.mp.4001924","article-title":"Towards a muscarinic hypothesis of schizophrenia","volume":"12","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"2026092408000872000_2026.09.18.752670v1.46","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.71131"},{"key":"2026092408000872000_2026.09.18.752670v1.47","first-page":"e525","article-title":"Xanomeline\/Trospium (Cobenfy): A Novel Approach for the Treatment of Schizophrenia in Adults","volume":"32","year":"2025","journal-title":"Am. J. Ther"},{"key":"2026092408000872000_2026.09.18.752670v1.48","unstructured":"AbbVie Provides Update on Phase 2 Results for Emraclidine in Schizophrenia. AbbVie News Center https:\/\/news.abbvie.com\/2024-11-11-AbbVie-Provides-Update-on-Phase-2-Results-for-Emraclidine-in-Schizophrenia."},{"key":"2026092408000872000_2026.09.18.752670v1.49","doi-asserted-by":"publisher","DOI":"10.1038\/nature09915"},{"key":"2026092408000872000_2026.09.18.752670v1.50","doi-asserted-by":"crossref","unstructured":"Kathuria, A. , Lopez-Lengowski, K. , Watmuff, B. & Karmacharya, R . Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia. Genome Med. 15, 58 (2023).","DOI":"10.1186\/s13073-023-01203-5"},{"key":"2026092408000872000_2026.09.18.752670v1.51","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.1.65"},{"key":"2026092408000872000_2026.09.18.752670v1.52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006780"},{"key":"2026092408000872000_2026.09.18.752670v1.53","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.06.611689"},{"key":"2026092408000872000_2026.09.18.752670v1.54","doi-asserted-by":"crossref","unstructured":"McLaren, W. et al. The Ensembl Variant Effect Predictor. Genome Biol. 17, 122 (2016).","DOI":"10.1186\/s13059-016-0974-4"},{"key":"2026092408000872000_2026.09.18.752670v1.55","doi-asserted-by":"publisher","DOI":"10.1101\/2023.11.27.23299062"},{"key":"2026092408000872000_2026.09.18.752670v1.56","doi-asserted-by":"publisher","DOI":"10.1101\/2024.09.17.613327"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.18.752670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:00:29Z","timestamp":1790262029000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.09.18.752670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":56,"URL":"https:\/\/doi.org\/10.64898\/2026.09.18.752670","relation":{},"subject":[],"published":{"date-parts":[[2026,9,21]]},"subtype":"preprint"}}