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GD2 is not present on most normal tissues except for nerves. Thus, anti-GD2 antibody treatment causes substantial, dose-limiting neuropathic pain. B7-H3 is overexpressed on multiple tumor types, including neuroblastoma, and is largely absent on nerves and other normal tissues. We designed a bispecific antibody (bsAb) that requires simultaneous binding of these two tumor antigens to achieve tight binding of tumor cells. Our preclinical research shows that, compared with a monospecific anti-GD2 antibody, the GD2\u00d7B7-H3 bsAb has improved tumor specificity, comparable antitumor efficacy, and reduced nerve binding and pain-associated toxicity. Since this bsAb does not bind to nerves, it may permit more tolerable and sustained treatment schedules than are currently feasible with monospecific anti-GD2 antibodies. In addition, its enhanced tumor specificity may support future development as a targeted delivery platform for antibody-drug conjugates or other payload-based therapies, potentially improving both efficacy and quality of life for patients with neuroblastoma.<\/jats:p>","DOI":"10.64898\/2026.09.21.753180","type":"posted-content","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:00:20Z","timestamp":1790096420000},"source":"Crossref","is-referenced-by-count":0,"title":["Bispecific GD2xB7-H3 Antibody Improves Tumor Targeting and Reduces Toxicity while Maintaining Efficacy for Neuroblastoma"],"prefix":"10.64898","author":[{"given":"Amy K.","family":"Erbe","sequence":"first","affiliation":[{"name":"Dept. of Human Oncology, University of Wisconsin, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arika S.","family":"Feils","sequence":"additional","affiliation":[{"name":"Dept. of Human Oncology, University of Wisconsin, Madison, WI, 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