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In male C57BL\/6J, B6129SF2\/J, and DO\/J mice, we report conserved and divergent cocaine-induced neuroplasticity in the accumbens shell following 5 days of cocaine and 10\u201314 days of abstinence.<\/jats:p>","DOI":"10.64898\/2026.09.21.753182","type":"posted-content","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:55:18Z","timestamp":1790628918000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5167-7949","authenticated-orcid":false,"given":"Chinonso A.","family":"Nwakama","sequence":"first","affiliation":[{"name":"Medical Scientist Training Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029"},{"name":"Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029"},{"name":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-1772","authenticated-orcid":false,"given":"Andrew D.","family":"Chapp","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611"},{"name":"Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026093009550933000_2026.09.21.753182v1.1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41591-025-04137-0","article-title":"Global burden of amphetamine, cannabis, cocaine and opioid use in 204 countries, 1990\u20132023: a Global Burden of Disease Study","volume":"32","year":"2026","journal-title":"Nature Medicine"},{"key":"2026093009550933000_2026.09.21.753182v1.2","doi-asserted-by":"crossref","unstructured":"S. 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