{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:18:37Z","timestamp":1792790317210,"version":"4.5.0"},"posted":{"date-parts":[[2026,9,23]]},"group-title":"Cell Biology","reference-count":55,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["805046"],"award-info":[{"award-number":["805046"]}],"id":[{"id":"https:\/\/ror.org\/0472cxd90","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Norwegian Research Council","award":["357812"],"award-info":[{"award-number":["357812"]}]},{"name":"Norwegian Research Council","award":["360449"],"award-info":[{"award-number":["360449"]}]},{"award":["MCB&#8208;1933590"],"award-info":[{"award-number":["MCB&#8208;1933590"]}],"id":[{"id":"https:\/\/ror.org\/021nxhr62","id-type":"ROR","asserted-by":"publisher"}]},{"name":"NIH COBRE","award":["P20 GM113126"],"award-info":[{"award-number":["P20 GM113126"]}]},{"name":"University of Nebraska Foundation","award":["01146140"],"award-info":[{"award-number":["01146140"]}],"id":[{"id":"https:\/\/ror.org\/05nrs2490","id-type":"ROR","asserted-by":"crossref"}]},{"name":"L. 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We show that wildtype\n                  <jats:italic>Arabidopsis<\/jats:italic>\n                  mitochondrial dynamics near-optimally resolve a tradeoff between maintaining physical spacing and supporting biomolecular exchange. With existing and new experimental data, we show that these dynamics adapt under mutational and chemical challenges to support a rebalanced, but still near-optimal, resolution to this tradeoff under different densities of the mitochondrial population. We also show how an assumption of multi-objective optimisation supports inference of biological mechanisms before any data are observed, and discuss the potential of this multi-objective optimisation paradigm to form a broader theoretical framework of spatial cell biology.\n                <\/jats:p>","DOI":"10.64898\/2026.09.22.753427","type":"posted-content","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:35:14Z","timestamp":1790152514000},"source":"Crossref","is-referenced-by-count":0,"title":["Mitochondrial dynamics resolve physical-social tensions and challenges through adaptable multi-objective optimisation"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-8415","authenticated-orcid":false,"given":"Joanna M.","family":"Chustecki","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Nebraska-Lincoln, Nebraska, USA"},{"name":"Department of Biology, University of Oxford, Oxford, UK"},{"name":"Institute of Plant Biology and Biotechnology, University of M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-3519","authenticated-orcid":false,"given":"Iain G.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Bergen, Bergen, Norway"},{"name":"Computational Biology Unit, University of Bergen, Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092615150567000_2026.09.22.753427v1.1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009073"},{"key":"2026092615150567000_2026.09.22.753427v1.2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.130.018401"},{"key":"2026092615150567000_2026.09.22.753427v1.3","doi-asserted-by":"publisher","DOI":"10.1104\/pp.17.01025"},{"key":"2026092615150567000_2026.09.22.753427v1.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401077101"},{"key":"2026092615150567000_2026.09.22.753427v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/162.4.2025"},{"key":"2026092615150567000_2026.09.22.753427v1.6","doi-asserted-by":"publisher","DOI":"10.1103\/PRXLife.2.043005"},{"key":"2026092615150567000_2026.09.22.753427v1.7","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erac250"},{"key":"2026092615150567000_2026.09.22.753427v1.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2021.04.006"},{"key":"2026092615150567000_2026.09.22.753427v1.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2023.09.005"},{"key":"2026092615150567000_2026.09.22.753427v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2018.06.003"},{"key":"2026092615150567000_2026.09.22.753427v1.11","doi-asserted-by":"crossref","unstructured":"Collette, Y. , & Siarry, P. 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