{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:59:32Z","timestamp":1790459972950,"version":"4.1.0"},"posted":{"date-parts":[[2026,9,23]]},"group-title":"Cancer Biology","reference-count":78,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"Department of Defense Ovarian Cancer Research Program","award":["W81XWH-21-1-0284"],"award-info":[{"award-number":["W81XWH-21-1-0284"]}]},{"name":"Department of Defense Ovarian Cancer Research Program","award":["P30CA082709-25"],"award-info":[{"award-number":["P30CA082709-25"]}]},{"name":"Van Andel Research Institute - Stand Up To Cancer Epigenetics Dream Team"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Advanced-stage high grade serous ovarian cancer (HGSC) initially responds to platinum-based chemotherapy; however, most HGSC tumors recur and develop chemotherapy-resistance, making recurrent ovarian cancer (OC) a fatal disease. Ovarian cancer stem cells (OCSCs), a subpopulation of cells capable of surviving treatment and repopulating tumors, contribute to disease relapse, and understanding the mechanisms(s) responsible for OCSC survival is critical for developing strategies to overcome acquired resistance and prevent tumor recurrence. However, whether platinum-induced OCSC enrichment results from the selection of pre-existing OCSCs or chemotherapy-induced cellular plasticity, and the molecular mechanisms underlying these processes, remain poorly understood. Here, we demonstrated that cisplatin treatment not only enriched for OCSCs but promoted the conversion of ALDH-cells to ALDH+ cells, revealing chemotherapy-induced plasticity as a potential mechanism for OCSC expansion. This conversion was associated with nuclear receptor signaling pathways, vitamin D receptor signaling (VDR\/RXR) and retinoic acid receptor signaling (RAR\/RXR). Importantly, activation of VDR\/RXR signaling with vitamin D reduced stemness phenotypes and the cisplatin induced conversion to ALDH+ cells. In addition, vitamin D combined with cisplatin decreased tumor volume in vivo compared to either treatment alone. In contrast, cisplatin treatment increased RAR\/RXR signaling, supporting an associative role for ligand-dependent nuclear receptor signaling in OCSC plasticity. Together, these findings reveal that platinum chemotherapy can actively promote the acquisition of stem-like properties and identifies VDR\/RXR signaling as a potential regulatory mechanism of OCSC plasticity. Targeting this pathway with vitamin D may provide a therapeutic strategy to target OCSCs and improve responses to platinum-based chemotherapy.<\/jats:p>","DOI":"10.64898\/2026.09.22.753468","type":"posted-content","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:25:15Z","timestamp":1790173515000},"source":"Crossref","is-referenced-by-count":0,"title":["Activation of vitamin D signaling suppresses platinum-induced ovarian cancer stem cell plasticity"],"prefix":"10.64898","author":[{"given":"Tara X.","family":"Metcalfe","sequence":"first","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Xanders","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts & Sciences, Indiana University, Bloomington, IN 47405, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee A.","family":"Kinne","sequence":"additional","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saranya","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Arts & Sciences, Indiana University, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Hollenhorst","sequence":"additional","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8528-5575","authenticated-orcid":false,"given":"Alexandre","family":"Gaspar-Maia","sequence":"additional","affiliation":[{"name":"Division of Experimental Pathology, Department of Lab Medicine and Pathology, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"O\u2019Hagan","sequence":"additional","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"},{"name":"Department of Medical & Molecular Genetics, Indiana University School of Medicine Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth P.","family":"Nephew","sequence":"additional","affiliation":[{"name":"Medical Sciences Program, Indiana University School of Medicine-Bloomington, Bloomington, IN 47405, USA"},{"name":"Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 4602, USA"},{"name":"Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine Indianapolis, IN 46202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026092614500816000_2026.09.22.753468v1.1","first-page":"76","volume":"2026","year":"2026","journal-title":"CA Cancer J Clin"},{"key":"2026092614500816000_2026.09.22.753468v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc4019"},{"key":"2026092614500816000_2026.09.22.753468v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605626"},{"key":"2026092614500816000_2026.09.22.753468v1.4","doi-asserted-by":"crossref","unstructured":"Muralikrishnan V , Hurley TD , Nephew KP . Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies. Cancers (Basel) 2020; 12 (4).","DOI":"10.3390\/cancers12040961"},{"key":"2026092614500816000_2026.09.22.753468v1.5","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0788"},{"key":"2026092614500816000_2026.09.22.753468v1.6","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0975-0"},{"key":"2026092614500816000_2026.09.22.753468v1.7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065158"},{"issue":"14","key":"2026092614500816000_2026.09.22.753468v1.8","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.3390\/cancers14143437","article-title":"A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer","volume":"14","year":"2022","journal-title":"Cancers"},{"key":"2026092614500816000_2026.09.22.753468v1.9","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3175"},{"key":"2026092614500816000_2026.09.22.753468v1.10","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03447-y"},{"key":"2026092614500816000_2026.09.22.753468v1.11","doi-asserted-by":"crossref","unstructured":"Wang Y , Zong X , Mitra S et al. IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells. JCI Insight 2018; 3 (23).","DOI":"10.1172\/jci.insight.122360"},{"key":"2026092614500816000_2026.09.22.753468v1.12","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8852"},{"key":"2026092614500816000_2026.09.22.753468v1.13","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1022"},{"key":"2026092614500816000_2026.09.22.753468v1.14","doi-asserted-by":"crossref","unstructured":"Thankamony AP , Saxena K , Murali R et al. Cancer Stem Cell Plasticity - A Deadly Deal. Front Mol Biosci 2020; 7: 79.","DOI":"10.3389\/fmolb.2020.00079"},{"key":"2026092614500816000_2026.09.22.753468v1.15","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1740936"},{"key":"2026092614500816000_2026.09.22.753468v1.16","doi-asserted-by":"crossref","unstructured":"De Angelis ML , Francescangeli F , La Torre F et al. Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance. Front Oncol 2019; 9: 626.","DOI":"10.3389\/fonc.2019.00626"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.17","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41392-023-01500-w","article-title":"Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response","volume":"8","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026092614500816000_2026.09.22.753468v1.18","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3513"},{"key":"2026092614500816000_2026.09.22.753468v1.19","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812876116"},{"key":"2026092614500816000_2026.09.22.753468v1.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.005"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.21","doi-asserted-by":"crossref","first-page":"22619","DOI":"10.1038\/s41598-024-73581-8","article-title":"A live single-cell reporter system reveals drug-induced plasticity of a cancer stem cell-like population in cholangiocarcinoma","volume":"14","year":"2024","journal-title":"Sci Rep"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10555-024-10171-0","article-title":"Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics","volume":"43","year":"2024","journal-title":"Cancer Metastasis Rev"},{"key":"2026092614500816000_2026.09.22.753468v1.23","doi-asserted-by":"publisher","DOI":"10.1210\/me.2010-0215"},{"key":"2026092614500816000_2026.09.22.753468v1.24","doi-asserted-by":"publisher","DOI":"10.1210\/me.2004-0210"},{"key":"2026092614500816000_2026.09.22.753468v1.25","doi-asserted-by":"crossref","unstructured":"Brown G . Retinoic acid receptor regulation of decision-making for cell differentiation. Front Cell Dev Biol 2023; 11: 1182204.","DOI":"10.3389\/fcell.2023.1182204"},{"key":"2026092614500816000_2026.09.22.753468v1.26","doi-asserted-by":"crossref","unstructured":"Wu D , Khan FA , Zhang K et al. Retinoic acid signaling in development and differentiation commitment and its regulatory topology. Chem Biol Interact 2024; 387: 110773.","DOI":"10.1016\/j.cbi.2023.110773"},{"key":"2026092614500816000_2026.09.22.753468v1.27","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0462"},{"key":"2026092614500816000_2026.09.22.753468v1.28","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv370"},{"key":"2026092614500816000_2026.09.22.753468v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2017.07.007"},{"key":"2026092614500816000_2026.09.22.753468v1.30","unstructured":"Mintao Ji LL , Yongfeng Hou and Bingyan Li . 1\u03b1,25-Dihydroxyvitamin D3 restrains stem cell-like properties of ovarian cancer cells by enhancing VDR and suppressing CD44. Oncology Reports 2019 (41): 3393\u20133403."},{"key":"2026092614500816000_2026.09.22.753468v1.31","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-23-0314"},{"key":"2026092614500816000_2026.09.22.753468v1.32","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9053"},{"key":"2026092614500816000_2026.09.22.753468v1.33","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2020-4371"},{"key":"2026092614500816000_2026.09.22.753468v1.34","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-20-0826"},{"key":"2026092614500816000_2026.09.22.753468v1.35","doi-asserted-by":"crossref","unstructured":"Selvaraj N , Budka JA , Ferris MW et al. Prostate cancer ETS rearrangements switch a cell migration gene expression program from RAS\/ERK to PI3K\/AKT regulation. Mol Cancer 2014; 13: 61.","DOI":"10.1186\/1476-4598-13-61"},{"key":"2026092614500816000_2026.09.22.753468v1.36","doi-asserted-by":"crossref","unstructured":"Liu WX , Huang XX , Luo WZ et al. The Role of Paxillin Aberrant Expression in Cancer and Its Potential as a Target for Cancer Therapy. International Journal of Molecular Sciences 2023; 24 (9).","DOI":"10.3390\/ijms24098245"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.37","doi-asserted-by":"crossref","first-page":"116708","DOI":"10.1016\/j.celrep.2025.116708","article-title":"Single-cell resolution of an open chromatin signature in persister tumor cells","volume":"45","year":"2026","journal-title":"Cell Rep"},{"issue":"4","key":"2026092614500816000_2026.09.22.753468v1.38","doi-asserted-by":"crossref","first-page":"101025","DOI":"10.1016\/j.tranon.2021.101025","article-title":"Exploitation of the vitamin A\/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin","volume":"14","year":"2021","journal-title":"Transl Oncol"},{"key":"2026092614500816000_2026.09.22.753468v1.39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.07.010"},{"key":"2026092614500816000_2026.09.22.753468v1.40","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.14"},{"issue":"4","key":"2026092614500816000_2026.09.22.753468v1.41","first-page":"229","article-title":"STRA6: role in cellular retinol uptake and efflux","volume":"4","year":"2015","journal-title":"Hepatobiliary Surg Nutr"},{"key":"2026092614500816000_2026.09.22.753468v1.42","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3932"},{"key":"2026092614500816000_2026.09.22.753468v1.43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ebiom.2016.01.007","article-title":"Phenotypic Plasticity Determines Cancer Stem Cell Therapeutic Resistance in Oral Squamous Cell Carcinoma","volume":"4","year":"2016","journal-title":"EBioMedicine"},{"key":"2026092614500816000_2026.09.22.753468v1.44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.03.027"},{"key":"2026092614500816000_2026.09.22.753468v1.45","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.31"},{"issue":"3","key":"2026092614500816000_2026.09.22.753468v1.46","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/15384101.2015.1127471","article-title":"Bulk pancreatic cancer cells can convert into cancer stem cells(CSCs) in vitro and 2 compounds can target these CSCs","volume":"15","year":"2016","journal-title":"Cell Cycle"},{"issue":"17","key":"2026092614500816000_2026.09.22.753468v1.47","doi-asserted-by":"crossref","first-page":"28074","DOI":"10.18632\/oncotarget.15888","article-title":"HIF1alpha regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia","volume":"8","year":"2017","journal-title":"Oncotarget"},{"key":"2026092614500816000_2026.09.22.753468v1.48","doi-asserted-by":"crossref","unstructured":"Bastos VAF , Souza AG , Guedes VCS et al. Shared and Context-Specific Mechanisms of EMT and Cellular Plasticity in Cancer and Fibrotic Diseases. Int J Mol Sci 2025; 26 (19).","DOI":"10.3390\/ijms26199476"},{"key":"2026092614500816000_2026.09.22.753468v1.49","doi-asserted-by":"crossref","unstructured":"Zheng XB , Dai FZ , Feng L et al. Communication Between Epithelial-Mesenchymal Plasticity and Cancer Stem Cells: New Insights Into Cancer Progression. Frontiers in Oncology 2021; 11.","DOI":"10.3389\/fonc.2021.617597"},{"key":"2026092614500816000_2026.09.22.753468v1.50","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9908"},{"key":"2026092614500816000_2026.09.22.753468v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.05.031"},{"key":"2026092614500816000_2026.09.22.753468v1.52","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1505-4"},{"key":"2026092614500816000_2026.09.22.753468v1.53","doi-asserted-by":"crossref","unstructured":"Tanabe S , Quader S , Cabral H et al. Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies. Front Pharmacol 2020; 11: 904.","DOI":"10.3389\/fphar.2020.00904"},{"key":"2026092614500816000_2026.09.22.753468v1.54","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.33"},{"issue":"2","key":"2026092614500816000_2026.09.22.753468v1.55","doi-asserted-by":"crossref","first-page":"116909","DOI":"10.1016\/j.celrep.2025.116909","article-title":"A Jagged1-regulated hybrid-EMT state identifies pancreatic cancer stem cells","volume":"45","year":"2026","journal-title":"Cell Rep"},{"key":"2026092614500816000_2026.09.22.753468v1.56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0040-3"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41368-025-00417-0","article-title":"Partial-EMT in oral squamous cell carcinoma: molecular circuitry and clinical translation","volume":"18","year":"2026","journal-title":"Int J Oral Sci"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.58","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41392-020-00230-7","article-title":"VDR-SOX2 signaling promotes colorectal cancer stemness and malignancy in an acidic microenvironment","volume":"5","year":"2020","journal-title":"Signal Transduct Target Ther"},{"issue":"6","key":"2026092614500816000_2026.09.22.753468v1.59","first-page":"3393","article-title":"1alpha,25-Dihydroxyvitamin D3 restrains stem cell-like properties of ovarian cancer cells by enhancing vitamin D receptor and suppressing CD44","volume":"41","year":"2019","journal-title":"Oncol Rep"},{"key":"2026092614500816000_2026.09.22.753468v1.60","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1600"},{"issue":"18","key":"2026092614500816000_2026.09.22.753468v1.61","doi-asserted-by":"crossref","first-page":"14481","DOI":"10.18632\/oncotarget.24520","article-title":"Depleting ovarian cancer stem cells with calcitriol","volume":"9","year":"2018","journal-title":"Oncotarget"},{"key":"2026092614500816000_2026.09.22.753468v1.62","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3927"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.63","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00280-024-04660-w","article-title":"Vitamin D suppresses CD133+\/CD44 + cancer stem cell stemness by inhibiting NF-kappaB signaling and reducing NLRP3 expression in triple-negative breast cancer","volume":"94","year":"2024","journal-title":"Cancer Chemother Pharmacol"},{"key":"2026092614500816000_2026.09.22.753468v1.64","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jsbmb.2014.12.013","article-title":"HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)\/CD24(-\/low) tumor-initiating subpopulation in basal-like breast cancer","volume":"148","year":"2015","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2026092614500816000_2026.09.22.753468v1.65","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz059"},{"key":"2026092614500816000_2026.09.22.753468v1.66","doi-asserted-by":"crossref","unstructured":"Kuznia S , Zhu A , Akutsu T et al. Efficacy of vitamin D(3) supplementation on cancer mortality: Systematic review and individual patient data meta-analysis of randomised controlled trials. Ageing Res Rev 2023; 87: 101923.","DOI":"10.1016\/j.arr.2023.101923"},{"key":"2026092614500816000_2026.09.22.753468v1.67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.011614"},{"key":"2026092614500816000_2026.09.22.753468v1.68","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102896"},{"key":"2026092614500816000_2026.09.22.753468v1.69","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.6.2898"},{"key":"2026092614500816000_2026.09.22.753468v1.70","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.120.000296"},{"key":"2026092614500816000_2026.09.22.753468v1.71","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0121"},{"key":"2026092614500816000_2026.09.22.753468v1.72","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.7194"},{"key":"2026092614500816000_2026.09.22.753468v1.73","doi-asserted-by":"crossref","unstructured":"Dabrock A , Ernesti N , Will F et al. RAR-Dependent and RAR-Independent RXR Signaling in Stem-like Glioma Cells. Int J Mol Sci 2023; 24 (22).","DOI":"10.3390\/ijms242216466"},{"key":"2026092614500816000_2026.09.22.753468v1.74","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400776"},{"key":"2026092614500816000_2026.09.22.753468v1.75","doi-asserted-by":"publisher","DOI":"10.1002\/med.21578"},{"key":"2026092614500816000_2026.09.22.753468v1.76","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.001951"},{"issue":"1","key":"2026092614500816000_2026.09.22.753468v1.77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41523-024-00716-5","article-title":"Effects of RARalpha ligand binding domain mutations on breast fibroepithelial tumor function and signaling","volume":"11","year":"2025","journal-title":"NPJ Breast Cancer"},{"issue":"9","key":"2026092614500816000_2026.09.22.753468v1.78","first-page":"3511","article-title":"The relevance of vitamin D receptor (VDR) gene polymorphisms for cancer: a review of the literature","volume":"29","year":"2009","journal-title":"Anticancer Res"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.22.753468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:50:19Z","timestamp":1790459419000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.09.22.753468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":78,"URL":"https:\/\/doi.org\/10.64898\/2026.09.22.753468","relation":{},"subject":[],"published":{"date-parts":[[2026,9,23]]},"subtype":"preprint"}}