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Competing theories typically assume a spatially uniform signal, and standard recording methods average dopamine over substantial tissue volumes. Using two-photon imaging through microprisms in behaving mice, we reveal a pronounced spatial organization of Core dopamine dynamics. Posterior Core showed phasic dopamine increases to both rewards and aversive stimuli, with transfer to a predictive cue after learning. Anterior Core showed phasic decreases to aversive stimuli, weaker increases to reward, and higher tonic dopamine that was further amplified by cocaine. Rather than uniform or highly fragmented signals, the Core contains a smoothly graded mixture between two distinct sets of dopamine dynamics, neither matching canonical reward prediction errors.<\/jats:p>","DOI":"10.64898\/2026.09.23.753606","type":"posted-content","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:20:14Z","timestamp":1790709614000},"source":"Crossref","is-referenced-by-count":1,"title":["Divergent Dopamine Dynamics within the Accumbens Core"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-4819","authenticated-orcid":false,"given":"Seongtak","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7515-4093","authenticated-orcid":false,"given":"Dennis A.","family":"Burke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Kornbrek","sequence":"additional","affiliation":[{"name":"Neuroscience Graduate Program, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Farouq","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1219-4191","authenticated-orcid":false,"given":"Huijeong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-610X","authenticated-orcid":false,"given":"Vijay Mohan K.","family":"Namboodiri","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"},{"name":"Neuroscience Graduate Program, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"},{"name":"Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Berke","sequence":"additional","affiliation":[{"name":"Department of Neurology, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"},{"name":"Neuroscience Graduate Program, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"},{"name":"Kavli Institute for Fundamental Neuroscience, Center for Integrative Neuroscience, and Weill Institute for Neurosciences, University of California, San Francisco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026100319100547000_2026.09.23.753606v1.1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010213-115159"},{"key":"2026100319100547000_2026.09.23.753606v1.2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0152-y"},{"key":"2026100319100547000_2026.09.23.753606v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.021"},{"key":"2026100319100547000_2026.09.23.753606v1.4","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0191-4"},{"key":"2026100319100547000_2026.09.23.753606v1.5","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.16"},{"key":"2026100319100547000_2026.09.23.753606v1.6","unstructured":"R. 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