{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:53:23Z","timestamp":1791093203103,"version":"4.1.0"},"posted":{"date-parts":[[2026,9,30]]},"group-title":"Neuroscience","reference-count":27,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["GM150832"],"award-info":[{"award-number":["GM150832"]}],"id":[{"id":"https:\/\/ror.org\/04q48ey07","id-type":"ROR","asserted-by":"publisher"}]},{"award":["RR220021"],"award-info":[{"award-number":["RR220021"]}],"id":[{"id":"https:\/\/ror.org\/0003xa228","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Sleep, feeding, and metabolism are tightly coordinated outputs of the circadian system. Previous studies showed that chronic social isolation reduces sleep and increases feeding in\n                  <jats:italic>Drosophila<\/jats:italic>\n                  . Here, untargeted metabolomic profiling revealed that chronic social isolation induces a distinct metabolomic signature spanning amino acids, carbohydrates, and lipids, establishing a foundation for understanding the physiological consequences of social isolation.\n                <\/jats:p>","DOI":"10.64898\/2026.09.24.754212","type":"posted-content","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:35:36Z","timestamp":1790804136000},"source":"Crossref","is-referenced-by-count":0,"title":["Chronic Social Isolation Reshapes the Metabolome in\n                  <i>Drosophila<\/i>"],"prefix":"10.64898","author":[{"given":"Doris","family":"Migliaccio","sequence":"first","affiliation":[{"name":"Center for Biological Clocks Research, Department of Biology, Texas A&M University, College Station, TX 77843, United States"},{"name":"Interdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, TX 77843, United 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Biology, Texas A&M University, College Station, TX 77843, United States"},{"name":"Interdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, TX 77843, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026100322200515000_2026.09.24.754212v1.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113117"},{"key":"2026100322200515000_2026.09.24.754212v1.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280308"},{"key":"2026100322200515000_2026.09.24.754212v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112124"},{"key":"2026100322200515000_2026.09.24.754212v1.4","unstructured":"Office of the Surgeon, G. in Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General\u2019s Advisory on the Healing Effects of Social Connection and Community (US Department of Health and Human Services, 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