{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:28Z","timestamp":1792790368469,"version":"4.5.0"},"posted":{"date-parts":[[2026,10,1]]},"group-title":"Neuroscience","reference-count":89,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"National Science Foundation","award":["BRAIN IUCRC #2310939"],"award-info":[{"award-number":["BRAIN IUCRC #2310939"]}]},{"name":"National Science Foundation","award":["2304388 STTR"],"award-info":[{"award-number":["2304388 STTR"]}]},{"name":"National Institutes of Health","award":["RF1 NS125026"],"award-info":[{"award-number":["RF1 NS125026"]}]},{"name":"National Institutes of Health","award":["5K12NS129164-02"],"award-info":[{"award-number":["5K12NS129164-02"]}]},{"name":"National Institutes of Health","award":["R01-EY035826"],"award-info":[{"award-number":["R01-EY035826"]}]},{"name":"National Institutes of Health","award":["5R01NS134410"],"award-info":[{"award-number":["5R01NS134410"]}]},{"name":"National Institutes of Health","award":["K12 Neurosurgeon Research Career Development Program"],"award-info":[{"award-number":["K12 Neurosurgeon Research Career Development Program"]}]},{"name":"National Institutes of Health","award":["OT2NS129366"],"award-info":[{"award-number":["OT2NS129366"]}]},{"name":"Philanthropic funding from Dr. Charles Fields"},{"name":"Weill Neurohub Clinician-Scientist Award"},{"name":"Fitzgerald Translational Neuroscience Fund"},{"name":"Brain Aneurysm Foundation","id":[{"id":"https:\/\/ror.org\/044m9y381","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Institute of Neurological Disorders and Stroke","id":[{"id":"https:\/\/ror.org\/01s5ya894","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>The goal of building a whole-brain interface\u2014capable of generating a real-time digital representation of the state of the entire central nervous system\u2014has long been framed as a hardware challenge of recording simultaneously from ever-larger numbers of microelectrodes. Advances in high-resolution neural interfaces now enable electrophysiologic interaction with the human nervous system at spatial and temporal resolutions previously unattainable without disrupting tissue architecture or physiology. These capabilities create new opportunities for mechanistic neuroscience, neuroprosthetics, and precision-guided neurosurgery. With the advent of modern microelectrode array technology, however, the whole-brain interface has also become a data challenge. Rather than pursuing large-scale human brain recording purely through a single device placed in a single patient, we demonstrate here that systematic multi-subject aggregation, across brain regions and behavioral paradigms, in a common anatomical framework, can achieve something functionally similar to a whole-brain interface.<\/jats:p>\n                <jats:p>Here we present an approach to a functional atlas of the human central nervous system derived from high-resolution surface electrophysiology recordings obtained in the first 70 patients implanted with an anatomically conformal, thin-film neural interface positioned in more than 100 locations. The atlas comprises &gt;100,000 electrode deployments and catalogs placement across a broad range of neuroanatomic targets spanning the motor, sensory, language, auditory, and associative domains, as well as brainstem and spinal cord structures that have historically been difficult to access at high electrophysiologic resolution. Across participants, aggregated recordings reveal somatotopic organization, including digit representations that follow a lateral-to-medial ordering consistent with classical homuncular maps, with transitions between adjacent representations occurring over spatial scales of approximately 0.8\u20132.0 mm; canonical frequency-band signatures, such as movement-related beta-band suppression and focal high-gamma (70\u2013200 Hz) increases during motor and speech behaviors; and task-modulated population dynamics in both evoked and spontaneous activity across cortical, brainstem, and spinal cord regions. These findings yield insight into patterns of mesoscale electrophysiological dynamics conserved across the entire human central nervous system, suggesting that fine-scale functional organization is preserved across individuals when aligned to common anatomical landmarks. We further demonstrate several applications of these high-resolution recordings, including real-time neural decoding from upper extremity motor cortex to enable real-time neuroprosthetic control, and from ventrolateral cortex to decode cortical correlates of spoken language, facial movements, and complex facial expressions of emotion, supporting initial feasibility of combined verbal and nonverbal communication interfaces.<\/jats:p>\n                <jats:p>Together, these results establish a paradigm for approaching large-scale interfaces with the human brain, as well as a starting point for a scalable, extensible atlas of human electrophysiologic function designed to accelerate discovery across basic neuroscience, translational research, and clinical neurotechnology.<\/jats:p>","DOI":"10.64898\/2026.09.24.754261","type":"posted-content","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:07:42Z","timestamp":1790870862000},"source":"Crossref","is-referenced-by-count":0,"title":["Toward A Whole-Brain Interface Enabled by High-Resolution Surface Electrophysiology"],"prefix":"10.64898","author":[{"given":"Elton","family":"Ho","sequence":"first","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Barth","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Dister","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneil","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Poole","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Claudi","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly V.","family":"Lucas","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Hettick","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Woo","family":"Byun","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Anushiravani","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Murphy","sequence":"additional","affiliation":[{"name":"Precision Neuroscience Corporation, New York, NY, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Konrad","sequence":"additional","affiliation":[{"name":"West Virginia University Rockefeller Neuroscience Institute, Morgantown, WV, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Bhatia","sequence":"additional","affiliation":[{"name":"West Virginia University Rockefeller Neuroscience Institute, Morgantown, WV, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Adams","sequence":"additional","affiliation":[{"name":"West Virginia University Rockefeller Neuroscience Institute, Morgantown, WV, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Carte","sequence":"additional","affiliation":[{"name":"West Virginia University Rockefeller Neuroscience Institute, Morgantown, WV, United States of 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