{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:31Z","timestamp":1792790371111,"version":"4.5.0"},"posted":{"date-parts":[[2026,9,27]]},"group-title":"Neuroscience","reference-count":56,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.biorxiv.org\/about\/FAQ#license"}],"funder":[{"name":"National Institute on Aging","award":["R01AG082680"],"award-info":[{"award-number":["R01AG082680"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>Modest positive associations between episodic memory performance and whole hippocampal and hippocampal subfield volumes have been reported in numerous prior studies. A smaller number of studies have reported associations between hippocampal volume and performance on tests of non-mnemonic cognition. The present study examined whether these associations were evident in a lifespan sample of cognitively healthy adults. Of particular interest was whether any identified associations were sensitive to age, and whether associations between subfield volumes and mnemonic and non-mnemonic performance were subfield dependent. We acquired high-resolution T1- and T2-weighted structural images from 163 adults (18-87 years of age). Participants also undertook a comprehensive neuropsychological test battery and an in-scanner test of source memory. Principal components analysis was employed to reduce the neuropsychological test scores to 5 cognitive components. Two components reflected memory performance while the other three reflected different aspects of non-mnemonic cognition. Hippocampal subfields (Cornu Ammonis (CA)1, CA2-3, dentate gyrus (DG) and subiculum) were segmented and measured with the Automated Segmentation of Hippocampus Subfields (ASHS) package. Source memory performance was selectively associated across participants with CA2-3 volume. By contrast, both mnemonic and non-mnemonic component scores derived from the test battery were associated exclusively with the volume of the DG. All associations were age-invariant. The findings indicate that different cognitive domains can be dissociated by virtue of their associations with different hippocampal subfields. Of importance, these associations appear to be life-long and hence are unlikely to reflect individual differences in age-related decline in structural integrity.<\/jats:p>","DOI":"10.64898\/2026.09.25.754488","type":"posted-content","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:30:14Z","timestamp":1790497814000},"source":"Crossref","is-referenced-by-count":0,"title":["Different hippocampal subfield volumes predict source memory performance and general cognitive ability in an adult lifespan sample"],"prefix":"10.64898","author":[{"given":"Anjana S.","family":"Anandan","sequence":"first","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5389-0177","authenticated-orcid":false,"given":"Marianne","family":"de Chastelaine","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambereen","family":"Kidwai","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8798-8477","authenticated-orcid":false,"given":"Mingzhu","family":"Hou","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Rugg","sequence":"additional","affiliation":[{"name":"Center for Vital Longevity and School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX 75235, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026093004200596000_2026.09.25.754488v1.1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.70010"},{"key":"2026093004200596000_2026.09.25.754488v1.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2007.05.009"},{"key":"2026093004200596000_2026.09.25.754488v1.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.12.012"},{"key":"2026093004200596000_2026.09.25.754488v1.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.06.008"},{"key":"2026093004200596000_2026.09.25.754488v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad309"},{"key":"2026093004200596000_2026.09.25.754488v1.6","unstructured":"Benedict, R. 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