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However, the epigenetic and transcriptional regulators that control TAM function remain largely unidentified. Here we investigated the role of the SWI\/SNF chromatin remodeling complex in TAMs and whether disruption of SWI\/SNF function in TAMs could improve immunotherapy. Pharmacologic inhibition of SWI\/SNF ATPase activity improved the efficacy of checkpoint blockade immunotherapy, slowing tumor growth and reprogramming transcription broadly in tumor cells, tumor-infiltrating lymphocytes, and TAMs. To define the role of SWI\/SNF in TAMs specifically, we genetically deleted the SWI\/SNF subunit\n                  <jats:italic>Arid1a<\/jats:italic>\n                  in myeloid cells and found this was sufficient to suppress tumor progression and enhance checkpoint blockade response. Epigenomic and single cell analyses indicated that SWI\/SNF inhibition and ARID1A deletion in TAMs reduced accessibility at enhancers of genes associated with poor prognosis, such as\n                  <jats:italic>Spp1,<\/jats:italic>\n                  and increased accessibility at promoters of interferon-stimulated genes (ISGs). CD86 was elevated on ARID1A-deficient TAMs and the enhanced immunotherapy response required CD86 costimulation and CD8+ T cells. These findings establish ARID1A-dependent chromatin remodeling as a determinant of TAM gene expression programs and show that disruption of myeloid SWI\/SNF function improves checkpoint blockade immunotherapy via TAM reprogramming.\n                <\/jats:p>","DOI":"10.64898\/2026.09.25.754528","type":"posted-content","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:40:41Z","timestamp":1790606441000},"source":"Crossref","is-referenced-by-count":0,"title":["Disruption of the ARID1A-containing SWI\/SNF complex reprograms tumor-associated macrophages and enhances immunotherapy response"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7396-0086","authenticated-orcid":false,"given":"Helen M.","family":"McRae","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA"},{"name":"NOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for 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