{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:54:26Z","timestamp":1790870066115,"version":"4.1.0"},"posted":{"date-parts":[[2026,9,28]]},"group-title":"Cancer Biology","reference-count":77,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"award":["P50CA186786"],"award-info":[{"award-number":["P50CA186786"]}],"id":[{"id":"https:\/\/ror.org\/040gcmg81","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Trailsend Foundation"},{"id":[{"id":"https:\/\/ror.org\/01npwtv09","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Myeloma Solutions Fund"},{"id":[{"id":"https:\/\/ror.org\/006w34k90","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Many cancers evade immunity by converting neutrophils into polymorphonuclear myeloid\n                  <jats:sub>-<\/jats:sub>\n                  derived suppressor cells (PMN-MDSCs), but the chromatin mechanisms that maintain this pathological state remain unclear. Here we show that tumor-induced suppressive neutrophils depend on mSWI\/SNF chromatin remodeling. Two orally bioavailable mSWI\/SNF ATPase antagonists, a degrader and a catalytic inhibitor, produced immune-dependent tumor control across syngeneic models, including tumors resistant to PD-1 blockade, and enhanced checkpoint therapy without overt toxicity. Treatment rapidly depleted intratumoral PMN-MDSCs, restored functional CD8\n                  <jats:sup>+<\/jats:sup>\n                  T cells, and blocked tumor explant-induced expansion and suppressive activity of mouse and human PMN-MDSCs. mSWI\/SNF antagonism collapsed chromatin accessibility and PU.1\/C\/EBP\u03b2 occupancy at regulatory elements that sustain PMN-MDSC identity. Thus, suppressive neutrophils harbor a druggable chromatin vulnerability that can be exploited to restore cancer immunity.\n                <\/jats:p>","DOI":"10.64898\/2026.09.26.754703","type":"posted-content","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:00:35Z","timestamp":1790607635000},"source":"Crossref","is-referenced-by-count":0,"title":["A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity"],"prefix":"10.64898","author":[{"given":"Fan","family":"Yang","sequence":"first","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Bao","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Qiao","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Cruz","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, 48109"},{"name":"Department of Pathology, University of Michigan, Ann Arbor, MI, 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Young","sequence":"additional","affiliation":[{"name":"Michigan Center for Translational 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