{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:35Z","timestamp":1791302555573,"version":"4.1.0"},"posted":{"date-parts":[[2026,10,2]]},"group-title":"Neurology","reference-count":13,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Global Parkinson's Genetics Program"},{"id":[{"id":"https:\/\/ror.org\/03zj4c476","id-type":"ROR","asserted-by":"publisher"}]},{"id":[{"id":"https:\/\/ror.org\/03arq3225","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Recent evidence suggests that TMEM106B expression is reduced in the brains of patients with Parkinson\u2019s disease (PD). However, an association between rare genetic variants in TMEM106B and PD risk has not been previously established. In this work, we investigated the association between rare TMEM106B variants and PD risk. We leveraged whole-genome sequencing data from 22,010 cases and 40,550 controls across diverse ancestries from the Global Parkinson\u2019s Genetics Program (GP2), the Accelerating Medicines Partnership in Parkinson\u2019s Disease (AMP-PD), and the UK Biobank (UKBB). A total of 4,581 unique rare variants were identified across all groups. We found no evidence that rare coding variants in TMEM106B were associated with PD risk, either individually or through cumulative burden. These findings suggest that rare variation in TMEM106B does not play a major role in PD susceptibility across the populations studied.<\/jats:p>","DOI":"10.64898\/2026.09.28.26363833","type":"posted-content","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:05:13Z","timestamp":1790989513000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>TMEM106B<\/i>\n                  analysis in diverse cohorts suggests no association with Parkinson\u2019s disease risk"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1649-7854","authenticated-orcid":false,"given":"Henry Mauricio","family":"Chaparro-Solano","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Aut\u00f3noma de Bucaramanga \u2013 UNAB, Avenida 42 No. 48-11, Bucaramanga, 680003, Colombia"},{"name":"Genomic Sciences and Systems Biology, Cleveland Clinic Research, 9500 Euclid Avenue, Cleveland Clinic, Cleveland, Ohio, 44195, USA"},{"name":"Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1841-1419","authenticated-orcid":false,"given":"Sajanth","family":"Kanagasingam","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"},{"name":"The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0332-234X","authenticated-orcid":false,"given":"Ziv","family":"Gan-Or","sequence":"additional","affiliation":[{"name":"The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Quebec, Canada, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3407-5716","authenticated-orcid":false,"given":"Konstantin","family":"Senkevich","sequence":"additional","affiliation":[{"name":"The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, Quebec, Canada"},{"name":"Department of Neurology and Neurosurgery, McGill University, Montr\u00e9al, Quebec, Canada, Canada"},{"name":"Department of Specialized Medicine, Division of Medical Genetics, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Global Parkinson\u2019s Genetic Program (GP2)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026100608450774000_2026.09.28.26363833v1.1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awag065"},{"key":"2026100608450774000_2026.09.28.26363833v1.2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0521-12.2012"},{"key":"2026100608450774000_2026.09.28.26363833v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/ng.536"},{"key":"2026100608450774000_2026.09.28.26363833v1.4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209832"},{"key":"2026100608450774000_2026.09.28.26363833v1.5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf019"},{"key":"2026100608450774000_2026.09.28.26363833v1.6","doi-asserted-by":"publisher","DOI":"10.1101\/2025.03.14.24319455"},{"key":"2026100608450774000_2026.09.28.26363833v1.7","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25486"},{"key":"2026100608450774000_2026.09.28.26363833v1.8","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-0974-4"},{"key":"2026100608450774000_2026.09.28.26363833v1.9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3538"},{"key":"2026100608450774000_2026.09.28.26363833v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01300-6"},{"key":"2026100608450774000_2026.09.28.26363833v1.11","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad214"},{"key":"2026100608450774000_2026.09.28.26363833v1.12","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx314"},{"key":"2026100608450774000_2026.09.28.26363833v1.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167553"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.28.26363833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:45:14Z","timestamp":1791301514000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.09.28.26363833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":13,"URL":"https:\/\/doi.org\/10.64898\/2026.09.28.26363833","relation":{},"subject":[],"published":{"date-parts":[[2026,10,2]]},"subtype":"preprint"}}