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During neonatal colonization by enterotoxigenic\n                  <jats:italic>Bacteroides fragilis<\/jats:italic>\n                  (ETBF), the metalloprotease toxin BFT enables lamina propria niche entry and remodeling of colonic epithelial cell states. Early-life ETBF exposure expands murine Lgr5\n                  <jats:sup>+<\/jats:sup>\n                  stem cells, enhances Atoh1\n                  <jats:sup>+<\/jats:sup>\n                  secretory differentiation, and induces distal colon-specific Wnt hyperactivation. These epithelial alterations coincide with increased formation of precancerous lesions in\n                  <jats:italic>Apc<\/jats:italic>\n                  <jats:sup>Min\/+<\/jats:sup>\n                  mice. ETBF preferentially forms intracellular bacterial aggregates within these lesions, establishing a persistent reservoir that reinforces epithelial remodeling. Colonization with non-toxigenic\n                  <jats:italic>B. fragilis<\/jats:italic>\n                  during this critical developmental window prevents lesion formation, revealing that developmental context dictates whether microbial colonization imprints protection or predisposition toward colorectal cancer.\n                <\/jats:p>","DOI":"10.64898\/2026.09.28.755180","type":"posted-content","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:30:11Z","timestamp":1790699411000},"source":"Crossref","is-referenced-by-count":0,"title":["Early-life colonization by enterotoxigenic\n                  <i>Bacteroides fragilis<\/i>\n                  remodels gut epithelial stem cell states to drive colorectal cancer susceptibility"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2012-4492","authenticated-orcid":false,"given":"Seongmi K.","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Washington University School of Medicine; 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