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Here, we characterize 88 monoclonal antibodies (mAbs) directed against the\n                  <jats:italic>Plasmodium falciparum<\/jats:italic>\n                  circumsporozoite protein cloned from African infants immunized with the RTS,S\/AS01\n                  <jats:sub>E<\/jats:sub>\n                  malaria vaccine, identifying potent antiparasitic mAbs exhibiting molecular features resembling those observed in adults and minimal somatic hypermutation. Importantly, germline-reverted variants of four mAbs inducing sterile protection\n                  <jats:italic>in vivo<\/jats:italic>\n                  maintained high binding affinity and Fab-dependent parasite killing. Structural analyses revealed that a few amino acid replacements drive homotypic helical assemblies, fine-tuning parasite inhibition and protective efficacy. Thus, despite maturational constraints of early life, infants can generate potent antimalarial antibodies in a near-germline configuration, informing next-generation vaccine development for this vulnerable group.\n                <\/jats:p>","DOI":"10.64898\/2026.10.01.755937","type":"posted-content","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:45:15Z","timestamp":1791189915000},"source":"Crossref","is-referenced-by-count":0,"title":["Protective near-germline antibodies to malaria elicited by RTS,S\/AS01\n                  <sub>E<\/sub>\n                  vaccination in African infants"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2227-9164","authenticated-orcid":false,"given":"Emma","family":"Bloch","sequence":"first","affiliation":[{"name":"ISGlobal, Barcelona, Spain"},{"name":"Facultat de Medicina i Ci\u00e8ncies de la Salut, Universitat de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Devys","sequence":"additional","affiliation":[{"name":"Institut Pasteur, INSERM, Universit\u00e9 Paris Cit\u00e9, Malaria Infection and Immunity, U1347 Parasitinnov, BioSPC, F-75015, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Cannac","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Broadbent","sequence":"additional","affiliation":[{"name":"Protein 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