{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"bioRxiv"}],"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:19:44Z","timestamp":1792790384897,"version":"4.5.0"},"posted":{"date-parts":[[2026,10,15]]},"group-title":"Neuroscience","reference-count":85,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH Common Fund","award":["AI164769"],"award-info":[{"award-number":["AI164769"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH Common Fund","award":["AG076949"],"award-info":[{"award-number":["AG076949"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH Common Fund","award":["MH133561"],"award-info":[{"award-number":["MH133561"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIH Common Fund","award":["AG080790"],"award-info":[{"award-number":["AG080790"]}],"id":[{"id":"https:\/\/ror.org\/001d55x84","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Bill Herrlinger Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                <jats:p>Globally, a person dies by suicide every 40 seconds, underscoring a major global public health concern. In the United States, suicide is the second leading cause of death among individuals aged 10-34 years. Suicide is a complex, multifactorial phenomenon influenced by genetic and epigenetic factors and is strongly associated with mood disorders, particularly major depressive disorder (MDD) and bipolar disorder (BD). However, the extent to which their molecular signatures converge or diverge across disorders and brain regions remains incompletely understood. To address this gap, we conducted a systematic literature review of suicide, MDD, and BD transcriptomic studies in accordance with PRISMA 2020 guidelines, searching PubMed, Embase, and Web of Science. Eligible studies used human postmortem brain tissue, reported a complete genome-wide transcriptomic list of differentially expressed genes (DEG), and compared suicide decedents with psychiatric non-suicide individuals diagnosed with the same underlying disorder. Regarding BD, studies comparing affected individuals to unaffected controls were included. Single-cell and peripheral-blood studies were excluded because unavailable for suicide. Curated suicide and BD DEG datasets were integrated with a published bulk transcriptomic dataset of MDD. We identified both shared and disease-specific molecular signatures across suicide, BD, and MDD, and identified DEGs shared across brain regions and those that were region-specific.<\/jats:p>\n                <jats:p>\n                  A total of 276 genes were shared across all three conditions, implicating cellular stress, hypoxia (\n                  <jats:italic>VEGFA, ADM, NDRG1, DDIT4<\/jats:italic>\n                  ), immune and inflammatory signaling through TNF\u03b1\/NF-\u03baB (\n                  <jats:italic>IL1B, ICAM1, NFE2L2<\/jats:italic>\n                  ) and IL6-JAK-STAT3 pathways (\n                  <jats:italic>STAT3, SOCS3, IL1R1m OSMR<\/jats:italic>\n                  ), complement activation (\n                  <jats:italic>CIR, SERPiNA1, LGALS3<\/jats:italic>\n                  ), extracellular matrix remodeling (\n                  <jats:italic>COL4A1, SERPINH1, PLOD2<\/jats:italic>\n                  ), and unfolded protein response (\n                  <jats:italic>BAG3, WFS1, MTHFD2<\/jats:italic>\n                  ). Suicide-associated DEGs were prominently downregulated, and involved metal-ion homeostasis, stress responses, synaptic regulation, and circadian pathways, whereas BD showed downregulation in synaptic and vesicle-related processes alongside region-specific metabolic dysregulation. MDD exhibited changes in RNA processing, ribosomal function, and protein synthesis. Genetic integration revealed that 133 genes shared between BD and MDD had gene variants associated with the corresponding condition per GWAS. Transcription factor analysis identified 20 regulatory factors with altered activity across all three conditions despite differences in their predicted downstream targets. Overall, these findings suggest that suicide, MDD, and BD share aspects of their molecular and regulatory pathophysiology while exhibiting distinct patterns, including in a region-specific manner.\n                <\/jats:p>","DOI":"10.64898\/2026.10.14.759202","type":"posted-content","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:25:16Z","timestamp":1792092316000},"source":"Crossref","is-referenced-by-count":0,"title":["Convergent and Distinct Transcriptional Signatures in Suicide, Bipolar Disorder, and Major Depressive Disorder"],"prefix":"10.64898","author":[{"given":"Ruchika","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Columbia University, New York, NY, 10032 USA"},{"name":"Preclinical Research Division, New York State Psychiatric Institute, New York, NY, 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Wamalwa","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University, New York, NY, 10032 USA"},{"name":"Preclinical Research Division, New York State Psychiatric Institute, New York, NY, 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Guasoni","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University, New York, NY, 10032 USA"},{"name":"Preclinical Research Division, New York State Psychiatric Institute, New York, NY, 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura B.","family":"Dupont","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Columbia University, New York, NY, 10032 USA"},{"name":"Preclinical Research Division, New York State Psychiatric Institute, New York, NY, 10032 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026101910552103000_2026.10.14.759202v1.1","unstructured":"Matthew F. Garnett, M.P.H. , and Sally C. Curtin, M.A. Suicide Mortality in the United States, 2001\u20132021. (U.S. Department of Health and Human Services \u2022 Centers for Disease Control and Prevention \u2022 National Center for Health Statistics \u2022 National Vital Statistics System, Hyattsville, MD: National Center for Health Statistics., 2023)."},{"key":"2026101910552103000_2026.10.14.759202v1.2","doi-asserted-by":"crossref","unstructured":"Wasserman, D. Negative life events (losses, changes, traumas and narcissistic injury) and suicide. in Suicide: An Unnecessary Death (ed. Wasserman, D. ) 111\u2013117 (Martin Danutz, London, 2001).","DOI":"10.1201\/b14713-22"},{"key":"2026101910552103000_2026.10.14.759202v1.3","doi-asserted-by":"publisher","DOI":"10.1038\/515180a"},{"key":"2026101910552103000_2026.10.14.759202v1.4","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.184.5.386"},{"key":"2026101910552103000_2026.10.14.759202v1.5","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09298"},{"key":"2026101910552103000_2026.10.14.759202v1.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.08.009"},{"key":"2026101910552103000_2026.10.14.759202v1.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.027"},{"key":"2026101910552103000_2026.10.14.759202v1.8","doi-asserted-by":"crossref","first-page":"e1131","DOI":"10.1038\/tp.2017.99","article-title":"A continuum of genetic liability for minor and major depression","volume":"7","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"2026101910552103000_2026.10.14.759202v1.9","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1038\/s41380-020-00984-0","article-title":"Genome-wide association study of patients with a severe major depressive episode treated with electroconvulsive therapy","volume":"26","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"2026101910552103000_2026.10.14.759202v1.10","doi-asserted-by":"publisher","DOI":"10.1038\/nature14659"},{"key":"2026101910552103000_2026.10.14.759202v1.11","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0090-3"},{"key":"2026101910552103000_2026.10.14.759202v1.12","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41593-021-00860-2","article-title":"Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions","volume":"24","year":"2021","journal-title":"Nat. Neurosci"},{"key":"2026101910552103000_2026.10.14.759202v1.13","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3623"},{"key":"2026101910552103000_2026.10.14.759202v1.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.08.004"},{"key":"2026101910552103000_2026.10.14.759202v1.15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2014.09.003","article-title":"Risk factors for suicide in bipolar disorder: a systematic review","volume":"170","year":"2015","journal-title":"Journal of affective disorders"},{"key":"2026101910552103000_2026.10.14.759202v1.16","unstructured":"Eroglu, M.Z. , Karakus, G. , Tamam, L. : Bipolar disorder and suicide. Dusunen Adam 26(2), 139 (2013). (2013)."},{"key":"2026101910552103000_2026.10.14.759202v1.17","doi-asserted-by":"crossref","unstructured":"Jones, S. , Riste, L. , Barrowclough, C. , Bartlett, P. , Clements, C. , Davies, L. , Holland, F. , Kapur, N. , Lobban, F. , Long, R. , et al: Reducing relapse and suicide in bipolar disorder: practical clinical approaches to identifying risk, reducing harm and engaging service users in planning and delivery of care\u2013the parades (psychoeducation, anxiety, relapse, advance directive evaluation and suicidality) programme (2018). (2018).","DOI":"10.3310\/pgfar06060"},{"key":"2026101910552103000_2026.10.14.759202v1.18","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.170.3.205"},{"key":"2026101910552103000_2026.10.14.759202v1.19","unstructured":"Mayo Clinic Staff . Mayo Clinic . Bipolar disorder \u2013 symptoms and causes. (2026)."},{"key":"2026101910552103000_2026.10.14.759202v1.20","unstructured":"World Health Organization. Bipolar disorder. (2026)."},{"key":"2026101910552103000_2026.10.14.759202v1.21","doi-asserted-by":"crossref","unstructured":"Ma, G. et al. Current state and future directions of biomarkers for bipolar disorder: A systematic review of studies from 2013 to 2025. Eur. J. Psychiatry 39, 100317 (2025).","DOI":"10.1016\/j.ejpsy.2025.100317"},{"key":"2026101910552103000_2026.10.14.759202v1.22","unstructured":"National Institute for Health and Care Excellence (NICE). Bipolar disorder: assessment and management. NICE Guideline [CG185]. (2023)."},{"key":"2026101910552103000_2026.10.14.759202v1.23","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0018-x"},{"key":"2026101910552103000_2026.10.14.759202v1.24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S2215-0366(14)70220-2","article-title":"The neurobiology of suicide","volume":"1","year":"2014","journal-title":"Lancet Psychiatry"},{"key":"2026101910552103000_2026.10.14.759202v1.25","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2012.12050627"},{"key":"2026101910552103000_2026.10.14.759202v1.26","doi-asserted-by":"crossref","first-page":"430","DOI":"10.31887\/DCNS.2014.16.3\/jmann","article-title":"Increased DNA methylation in the suicide brain","volume":"16","year":"2014","journal-title":"Dialogues Clin. Neurosci"},{"key":"2026101910552103000_2026.10.14.759202v1.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.036"},{"key":"2026101910552103000_2026.10.14.759202v1.28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.11.001"},{"key":"2026101910552103000_2026.10.14.759202v1.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.10.008"},{"key":"2026101910552103000_2026.10.14.759202v1.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.04.020"},{"key":"2026101910552103000_2026.10.14.759202v1.31","doi-asserted-by":"crossref","unstructured":"Cabello-Arreola A , Ho AM , Ozerdem A , Cuellar-Barboza AB , Kucuker MU , Heppelmann CJ , et al. Differential dorsolateral prefrontal cortex proteomic profiles of suicide victims with mood disorders. Genes. 2020;11:256. [DOI] [PMC free article] [PubMed]. (2020).","DOI":"10.3390\/genes11030256"},{"key":"2026101910552103000_2026.10.14.759202v1.32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006585"},{"key":"2026101910552103000_2026.10.14.759202v1.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.04.014"},{"key":"2026101910552103000_2026.10.14.759202v1.34","first-page":"985","article-title":"Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood\/adolescent physical assault","volume":"18","year":"2012","journal-title":"Mol Psychiatry"},{"key":"2026101910552103000_2026.10.14.759202v1.35","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30901"},{"key":"2026101910552103000_2026.10.14.759202v1.36","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001574"},{"key":"2026101910552103000_2026.10.14.759202v1.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.04.002"},{"key":"2026101910552103000_2026.10.14.759202v1.38","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31040"},{"key":"2026101910552103000_2026.10.14.759202v1.39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015146"},{"key":"2026101910552103000_2026.10.14.759202v1.40","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30920"},{"key":"2026101910552103000_2026.10.14.759202v1.41","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.1.35"},{"key":"2026101910552103000_2026.10.14.759202v1.42","doi-asserted-by":"publisher","DOI":"10.1101\/2024.08.14.606080"},{"key":"2026101910552103000_2026.10.14.759202v1.43","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-01918-w"},{"key":"2026101910552103000_2026.10.14.759202v1.44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035367"},{"key":"2026101910552103000_2026.10.14.759202v1.45","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.130"},{"key":"2026101910552103000_2026.10.14.759202v1.46","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1556983"},{"key":"2026101910552103000_2026.10.14.759202v1.47","unstructured":"Zhang X , Valeri J , Eladawi MA , et al. Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder. MedRxiv. 2024 Apr 19:2024.04.17.24305854. Https:\/\/Pmc.Ncbi.Nlm.Nih.Gov\/Articles\/PMC11065019\/. (2024)."},{"key":"2026101910552103000_2026.10.14.759202v1.48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095875"},{"key":"2026101910552103000_2026.10.14.759202v1.49","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1574458"},{"key":"2026101910552103000_2026.10.14.759202v1.50","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-022-01024-6"},{"key":"2026101910552103000_2026.10.14.759202v1.51","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2022.100975"},{"key":"2026101910552103000_2026.10.14.759202v1.52","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1323527"},{"key":"2026101910552103000_2026.10.14.759202v1.53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2016.07.016"},{"key":"2026101910552103000_2026.10.14.759202v1.54","doi-asserted-by":"publisher","DOI":"10.3390\/genes10110946"},{"key":"2026101910552103000_2026.10.14.759202v1.55","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58278-2"},{"key":"2026101910552103000_2026.10.14.759202v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.06.002"},{"key":"2026101910552103000_2026.10.14.759202v1.57","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2015.14101279"},{"key":"2026101910552103000_2026.10.14.759202v1.58","doi-asserted-by":"publisher","DOI":"10.1038\/s41467023-42686-5"},{"key":"2026101910552103000_2026.10.14.759202v1.59","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4386"},{"key":"2026101910552103000_2026.10.14.759202v1.60","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-59115-4"},{"key":"2026101910552103000_2026.10.14.759202v1.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.09.012"},{"key":"2026101910552103000_2026.10.14.759202v1.62","doi-asserted-by":"crossref","unstructured":"Zhang, X. , Valeri, J. & Eladawi, M. A. Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder. medRxiv https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11065019\/ (2024).","DOI":"10.1101\/2024.04.17.24305854"},{"key":"2026101910552103000_2026.10.14.759202v1.63","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-48646-9"},{"key":"2026101910552103000_2026.10.14.759202v1.64","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0267-7"},{"key":"2026101910552103000_2026.10.14.759202v1.65","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01159-9"},{"key":"2026101910552103000_2026.10.14.759202v1.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.11.017"},{"key":"2026101910552103000_2026.10.14.759202v1.67","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2016.173"},{"key":"2026101910552103000_2026.10.14.759202v1.68","doi-asserted-by":"publisher","DOI":"10.1007\/s00109024-02487-9"},{"key":"2026101910552103000_2026.10.14.759202v1.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2020.113513"},{"key":"2026101910552103000_2026.10.14.759202v1.70","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00949-5"},{"key":"2026101910552103000_2026.10.14.759202v1.71","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2022.08.037"},{"key":"2026101910552103000_2026.10.14.759202v1.72","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02311-9"},{"key":"2026101910552103000_2026.10.14.759202v1.73","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.03.023"},{"key":"2026101910552103000_2026.10.14.759202v1.74","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.32423"},{"key":"2026101910552103000_2026.10.14.759202v1.75","doi-asserted-by":"crossref","unstructured":"Yang, R. , Roshani, D. , Gao, B. , Li, P. & Shang, N . Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications. Antioxidants 13, 825 (2024).","DOI":"10.3390\/antiox13070825"},{"key":"2026101910552103000_2026.10.14.759202v1.76","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-009-9320-6"},{"key":"2026101910552103000_2026.10.14.759202v1.77","doi-asserted-by":"publisher","DOI":"10.1111\/jne.70021"},{"key":"2026101910552103000_2026.10.14.759202v1.78","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.058"},{"key":"2026101910552103000_2026.10.14.759202v1.79","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02817-3"},{"key":"2026101910552103000_2026.10.14.759202v1.80","doi-asserted-by":"crossref","unstructured":"Kageyama, Y. et al. The Association Among Bipolar Disorder, Mitochondrial Dysfunction, and Reactive Oxygen Species. Biomolecules 15, 383 (2025).","DOI":"10.3390\/biom15030383"},{"key":"2026101910552103000_2026.10.14.759202v1.81","doi-asserted-by":"crossref","unstructured":"Lu, Y. , Xu, Y. , Sun, Y. et al. Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes. Mol Psychiatry (2026). https:\/\/doi.org\/10.1038\/s41380-026-03858-z. https:\/\/doi.org\/10.1038\/s41380-026-03858-z (2026) doi:10.1038\/s41380-026-03858-z.","DOI":"10.1038\/s41380-026-03858-z"},{"key":"2026101910552103000_2026.10.14.759202v1.82","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05133-8"},{"issue":"10","key":"2026101910552103000_2026.10.14.759202v1.83","first-page":"pgad299","volume":"2","year":"2023","journal-title":"Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress, PNAS Nexus"},{"key":"2026101910552103000_2026.10.14.759202v1.84","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/jamapsychiatry.2025.4613","article-title":"Brain and Blood Biomarkers of Major Depressive Disorder: A Systematic Review","volume":"83","year":"2026","journal-title":"JAMA Psychiatry"},{"key":"2026101910552103000_2026.10.14.759202v1.85","doi-asserted-by":"crossref","unstructured":"Peng, M. S. , Jiang, J. & Polizzi, L . Dysregulated adult hippocampal neurogenesis in major depressive disorder. Nat. Med. (2026).","DOI":"10.1038\/s41591-026-04571-8"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.10.14.759202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:55:30Z","timestamp":1792432530000},"score":1,"resource":{"primary":{"URL":"http:\/\/biorxiv.org\/lookup\/doi\/10.64898\/2026.10.14.759202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,15]]},"references-count":85,"URL":"https:\/\/doi.org\/10.64898\/2026.10.14.759202","relation":{},"subject":[],"published":{"date-parts":[[2026,10,15]]},"subtype":"preprint"}}