{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"medRxiv"}],"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:07:04Z","timestamp":1789135624538,"version":"build-2803163510"},"posted":{"date-parts":[[2026,9,8]]},"group-title":"Genetic and Genomic Medicine","reference-count":58,"publisher":"openRxiv","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"United States Department of Veterans Affairs","doi-asserted-by":"crossref","award":["MVP000"],"award-info":[{"award-number":["MVP000"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"United States Department of Veterans Affairs","doi-asserted-by":"crossref","award":["I01BX006482-05"],"award-info":[{"award-number":["I01BX006482-05"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000738","name":"United States Department of Veterans Affairs","doi-asserted-by":"crossref","award":["1IK2BX005058-01A2"],"award-info":[{"award-number":["1IK2BX005058-01A2"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"award":["3R01DA058862"],"award-info":[{"award-number":["3R01DA058862"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01DA054869"],"award-info":[{"award-number":["R01DA054869"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]},{"award":["R01DA037974"],"award-info":[{"award-number":["R01DA037974"]}],"id":[{"id":"https:\/\/ror.org\/01cwqze88","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2026,9,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                <jats:p>\n                  Genomic studies have improved our understanding of posttraumatic stress disorder (PTSD) biology. Epigenetic differences in DNA methylation can reflect environmental influences, which are critical in PTSD etiology, and may additionally differentiate between PTSD cases and controls or distinguish severity of PTSD symptoms. We conducted PTSD epigenome-wide association studies (EWAS) in a large cohort, n = 22,141 subjects from the United States V.A. Million Veteran Program (MVP), with the PTSD Checklist (PCL-17), including 17,674 European ancestry (EUR), 3,430 African ancestry (AFR), and 1,037 admixed American descent (AMR). We evaluated the 17-item PCL-Total as well as symptom subdomains (re-experiencing, avoidance, and hyperarousal), and used lasso regression on electronic health records to define lifetime PTSD diagnoses. There were 9,413 total cases of Lifetime PTSD and 27,257 controls, with 5,184 cases and 19,382 controls in EUR, 3,095 cases and 6,240 controls in AFR, and 1,134 cases and 1,635 controls in AMR. We identified a total of 241 epigenome-wide-significant associated CpG sites across all PTSD traits. We replicated 5 out of 11 CpG sites reported in a prior (Psychiatric Genomics Consortium) PTSD EWAS. Overlap with differentially methylated CpG sites in subregions of the amygdala and hippocampus of human postmortem brains of individuals with PTSD vs. controls was evaluated at the CpG and gene levels. Ten genes of the 195 identified in the brain study overlapped with the 192 identified in our EWAS. There was significant enrichment of genes downregulated in somatostatin interneurons and brain endothelial cells. Regression analyses showed that PTSD case status was significantly associated with accelerated DNA methylation aging. Contrary to previous PTSD EWAS findings, smoking status stratification suggested that the association between PTSD and methylation of the\n                  <jats:italic>AHRR<\/jats:italic>\n                  gene may be confounded by smoking status. Our findings showcase the largest-scale PTSD EWAS in multiple ancestries and the first large PTSD EWAS on symptom severity. We replicated several findings from previous EWAS and greatly extended current knowledge of the relationship between epigenetics and PTSD.\n                <\/jats:p>","DOI":"10.64898\/2026.09.04.26362177","type":"posted-content","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:15:12Z","timestamp":1788884112000},"source":"Crossref","is-referenced-by-count":0,"title":["Posttraumatic Stress Disorder Epigenome-Wide Association Studies in the Million Veteran Program"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4176-2936","authenticated-orcid":false,"given":"Sarah","family":"Beck","sequence":"first","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-9569","authenticated-orcid":false,"given":"Daniel F.","family":"Levey","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-156X","authenticated-orcid":false,"given":"Marco","family":"Galimberti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie","family":"Overstreet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8339-2717","authenticated-orcid":false,"given":"Jiarui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-9714","authenticated-orcid":false,"given":"Priya","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-3767","authenticated-orcid":false,"given":"Cecilia","family":"Dao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-0240","authenticated-orcid":false,"given":"Bluma J.","family":"Lesch","sequence":"additional","affiliation":[{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-8365","authenticated-orcid":false,"given":"Janitza L.","family":"Montalvo-Ortiz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The VA Million Veteran Program","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5384-9767","authenticated-orcid":false,"given":"J. Michael","family":"Gaziano","sequence":"additional","affiliation":[{"name":"Million Veteran Program (MVP) Coordinating Center, Veterans Affairs Healthcare System, Boston, MA, USA"},{"name":"Division of Aging, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA, USA"},{"name":"Department of Medicine, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-1726","authenticated-orcid":false,"given":"John H.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0745-6046","authenticated-orcid":false,"given":"Renato","family":"Polimanti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-326X","authenticated-orcid":false,"given":"Matthew J.","family":"Girgenti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9564-2871","authenticated-orcid":false,"given":"Murray B.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of California San Diego, La Jolla, CA, USA"},{"name":"School of Public Health, University of California San Diego, La Jolla, CA, USA"},{"name":"VA San Diego Healthcare System, San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-1859","authenticated-orcid":false,"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT, USA"},{"name":"Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Department of Genetics, Yale University School of Medicine, New Haven, CT, USA"},{"name":"Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"54368","reference":[{"key":"2026091106150972000_2026.09.04.26362177v1.1","first-page":"886","volume-title":"Diagnostic and statistical manual of mental disorders: DSM-IV","volume":"xxvii","author":"American Psychiatric Association","year":"1994"},{"key":"2026091106150972000_2026.09.04.26362177v1.2","doi-asserted-by":"publisher","DOI":"10.1037\/a0025989"},{"key":"2026091106150972000_2026.09.04.26362177v1.3","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.8.1184"},{"key":"2026091106150972000_2026.09.04.26362177v1.4","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2017.1353383"},{"key":"2026091106150972000_2026.09.04.26362177v1.5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000708"},{"key":"2026091106150972000_2026.09.04.26362177v1.6","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0447-7"},{"key":"2026091106150972000_2026.09.04.26362177v1.7","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-00767-x"},{"key":"2026091106150972000_2026.09.04.26362177v1.8","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01707-9"},{"key":"2026091106150972000_2026.09.04.26362177v1.9","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.16.2395"},{"key":"2026091106150972000_2026.09.04.26362177v1.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.04.003"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13073-024-01417-1","article-title":"Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts","volume":"16","year":"2024","journal-title":"Genome Med"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13148-020-0820-0","article-title":"An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci","volume":"12","year":"2020","journal-title":"Clin Epigenetics"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.13","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1038\/s41467-020-19615-x","article-title":"Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR","volume":"11","year":"2020","journal-title":"Nat Commun"},{"key":"2026091106150972000_2026.09.04.26362177v1.14","doi-asserted-by":"publisher","DOI":"10.4161\/epi.22520"},{"key":"2026091106150972000_2026.09.04.26362177v1.15","doi-asserted-by":"crossref","unstructured":"Jones, G.T. , et al., A DNA Methylation Marker, cg05575921 (AHRR), Outperforms Self-Reported Smoking Exposure for Its Association With Cardiovascular Disease Prevalence. Nicotine Tob Res, 2025.","DOI":"10.1093\/ntr\/ntaf165"},{"key":"2026091106150972000_2026.09.04.26362177v1.16","unstructured":"Weathers, F.W. , Litz, B.T. , Herman, D.S. , Huska, J.A. , and Keane, T.M. , The PTSD Checklist (PCL): Reliability, Validity, and Diagnostic Utility., in Annual Meeting of the International Society for Traumatic Stress Studies. 1993: San Antonio, TX."},{"key":"2026091106150972000_2026.09.04.26362177v1.17","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3211"},{"key":"2026091106150972000_2026.09.04.26362177v1.18","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1131-9"},{"key":"2026091106150972000_2026.09.04.26362177v1.19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-14-128"},{"key":"2026091106150972000_2026.09.04.26362177v1.20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"2026091106150972000_2026.09.04.26362177v1.21","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.90"},{"key":"2026091106150972000_2026.09.04.26362177v1.22","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03465-8"},{"key":"2026091106150972000_2026.09.04.26362177v1.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.06.021"},{"key":"2026091106150972000_2026.09.04.26362177v1.24","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2009.46"},{"issue":"3","key":"2026091106150972000_2026.09.04.26362177v1.25","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/JHD-210491","article-title":"HDinHD: A Rich Data Portal for Huntington\u2019s Disease Research","volume":"10","year":"2021","journal-title":"J Huntingtons Dis"},{"key":"2026091106150972000_2026.09.04.26362177v1.26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.12688\/wellcomeopenres.17598.2","article-title":"The EWAS Catalog: a database of epigenome-wide association studies","volume":"7","year":"2022","journal-title":"Wellcome Open Res"},{"key":"2026091106150972000_2026.09.04.26362177v1.27","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01596-4"},{"issue":"3","key":"2026091106150972000_2026.09.04.26362177v1.28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.molmet.2015.12.004","article-title":"Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients","volume":"5","year":"2016","journal-title":"Mol Metab"},{"issue":"20","key":"2026091106150972000_2026.09.04.26362177v1.29","doi-asserted-by":"crossref","first-page":"e90151","DOI":"10.1172\/jci.insight.90151","article-title":"DNA methylation in lung cells is associated with asthma endotypes and genetic risk","volume":"1","year":"2016","journal-title":"JCI Insight"},{"issue":"8","key":"2026091106150972000_2026.09.04.26362177v1.30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1080\/15592294.2015.1061174","article-title":"Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia","volume":"10","year":"2015","journal-title":"Epigenetics"},{"key":"2026091106150972000_2026.09.04.26362177v1.31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201066"},{"key":"2026091106150972000_2026.09.04.26362177v1.32","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-024-01757-0"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.33","doi-asserted-by":"crossref","first-page":"1863578","DOI":"10.1080\/20008198.2020.1863578","article-title":"Psychometric properties of the PTSD Checklist for DSM-5 in a sample of trauma exposed mental health service users","volume":"12","year":"2021","journal-title":"Eur J Psychotraumatol"},{"issue":"2","key":"2026091106150972000_2026.09.04.26362177v1.34","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/jts.22399","article-title":"Validation of an Electronic Medical Record-Based Algorithm for Identifying Posttraumatic Stress Disorder in U.S","volume":"32","year":"2019","journal-title":"Veterans. J Trauma Stress"},{"key":"2026091106150972000_2026.09.04.26362177v1.35","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"2026091106150972000_2026.09.04.26362177v1.36","doi-asserted-by":"crossref","unstructured":"Schreiner, P.A. , Markianos, K. , Francis, M. , Despard, B. , Gorman, B. R. , Said, I. , Dong, F. , Gautam, S. , Dochtermann, D. , Shi, Y. , Devineni, P. , Kirkpatrick, C. , Khazanov, N. , Moser, J. , VA Million Veteran Program , Huang, G. D. , Muralidhar, S. , Tsao, P. S. , Pyarajan, S. , Methylation profiling in the Million Veteran Program: design, quality control, and smoking-associated epigenetic signatures. medRxiv, 2026.","DOI":"10.64898\/2026.04.22.26351491"},{"key":"2026091106150972000_2026.09.04.26362177v1.37","doi-asserted-by":"publisher","DOI":"10.1093\/NAR\/GKY691"},{"key":"2026091106150972000_2026.09.04.26362177v1.38","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty476"},{"key":"2026091106150972000_2026.09.04.26362177v1.39","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r115"},{"key":"2026091106150972000_2026.09.04.26362177v1.40","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-86"},{"key":"2026091106150972000_2026.09.04.26362177v1.41","unstructured":"Song, R.J. , et al., Development of an Electronic Health Record-Based Algorithm for Smoking Status Using the Million Veteran Program (MVP) Cohort Survey Response. Circulation, 2016. 134."},{"key":"2026091106150972000_2026.09.04.26362177v1.42","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq340"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.43","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biopsych.2025.10.032","article-title":"Mapping DNA Methylation Signatures to Identify Epigenetic Variation Across Subcortical Regions of the Human Posttraumatic Stress Disorder Brain","volume":"100","year":"2026","journal-title":"Biol Psychiatry"},{"key":"2026091106150972000_2026.09.04.26362177v1.44","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw026"},{"key":"2026091106150972000_2026.09.04.26362177v1.45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1003118"},{"key":"2026091106150972000_2026.09.04.26362177v1.46","unstructured":"Hansen, K.D. , IlluminaHumanMethylationEPICanno.ilm10b4.hg19: Annotation for Illumina\u2019s EPIC methylation arrays. 2017."},{"key":"2026091106150972000_2026.09.04.26362177v1.47","doi-asserted-by":"crossref","unstructured":"Armstrong, J.F. , et al., CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research. bioRxiv, 2026.","DOI":"10.64898\/2026.05.30.729020"},{"key":"2026091106150972000_2026.09.04.26362177v1.48","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58357-6"},{"issue":"1","key":"2026091106150972000_2026.09.04.26362177v1.49","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41398-019-0376-y","article-title":"Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals","volume":"9","year":"2019","journal-title":"Transl Psychiatry"},{"key":"2026091106150972000_2026.09.04.26362177v1.50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.12.016"},{"issue":"8072","key":"2026091106150972000_2026.09.04.26362177v1.51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41586-025-09083-y","article-title":"Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD","volume":"643","year":"2025","journal-title":"Nature"},{"issue":"8","key":"2026091106150972000_2026.09.04.26362177v1.52","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s12264-022-00845-6","article-title":"Astrocytes in Post-traumatic Stress Disorder","volume":"38","year":"2022","journal-title":"Neurosci Bull"},{"key":"2026091106150972000_2026.09.04.26362177v1.53","doi-asserted-by":"crossref","unstructured":"Mourtzi, N. , A. Sertedaki , and E. Charmandari , Glucocorticoid Signaling and Epigenetic Alterations in Stress-Related Disorders. Int J Mol Sci, 2021. 22(11).","DOI":"10.3390\/ijms22115964"},{"key":"2026091106150972000_2026.09.04.26362177v1.54","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.08.017"},{"key":"2026091106150972000_2026.09.04.26362177v1.55","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2270"},{"key":"2026091106150972000_2026.09.04.26362177v1.56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.06.001"},{"key":"2026091106150972000_2026.09.04.26362177v1.57","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291725000558"},{"key":"2026091106150972000_2026.09.04.26362177v1.58","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.psyneuen.2017.12.007","article-title":"Traumatic stress and accelerated DNA methylation age: A meta-analysis","volume":"92","year":"2018","journal-title":"Psychoneuroendocrinology"}],"container-title":[],"original-title":[],"link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.64898\/2026.09.04.26362177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:15:25Z","timestamp":1789132525000},"score":1,"resource":{"primary":{"URL":"http:\/\/medrxiv.org\/lookup\/doi\/10.64898\/2026.09.04.26362177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":58,"URL":"https:\/\/doi.org\/10.64898\/2026.09.04.26362177","relation":{},"subject":[],"published":{"date-parts":[[2026,9,8]]},"subtype":"preprint"}}