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NKX2-5 conferred robust oxidative resilience\n                  <jats:italic>in vitro<\/jats:italic>\n                  and\n                  <jats:italic>in vivo<\/jats:italic>\n                  . Domain dissection showed that its homeodomain was dispensable for resilience, enabling development of NKX2-5\u0394HD, which retained protective activity without detectable toxicity over 14 months. In middle-aged mice, subretinal NKX2-5\u0394HD restored visual and electrophysiological function, and its systemic delivery improved grip strength and reduced frailty in late-aged mice. These findings establish genome-scale ORF screening as a strategy to discover transferable resilience factors that can be reengineered to counter age-related functional decline across tissues.\n                <\/jats:p>","DOI":"10.64898\/2026.09.29.755187","type":"posted-content","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:45:23Z","timestamp":1790826323000},"source":"Crossref","is-referenced-by-count":0,"title":["A genome-scale ORF screen for resilience factors that protect the RPE and restore vision in aged mice"],"prefix":"10.64898","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5982-3963","authenticated-orcid":false,"given":"Yuancheng Ryan","family":"Lu","sequence":"first","affiliation":[{"name":"Whitehead Institute for Biomedical Research, MIT, Cambridge, MA, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Shen","sequence":"additional","affiliation":[{"name":"Schepens Eye Research Institute of Mass Eye and Ear, 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