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Here we show that hydrogen sulfide (H\n                  <jats:sub>\u2082<\/jats:sub>\n                  S) bioavailability declines in ageing and atherosclerosis and is associated with endothelial senescence. Developing a novel remote-control, endothelial-specific, mitochondria-targeted chemogenetic system, we spatiotemporally controlled H\n                  <jats:sub>\u2082<\/jats:sub>\n                  S generation and thereby mitigated endothelial senescence-driven programs and reversed vascular remodeling in aged mice.\n                <\/jats:p>","DOI":"10.64898\/2026.09.29.755422","type":"posted-content","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:50:29Z","timestamp":1790790629000},"source":"Crossref","is-referenced-by-count":0,"title":["Chemogenetic Hydrogen Sulfide Rescues Vascular Senescence in Ageing"],"prefix":"10.64898","author":[{"given":"Khatereh","family":"Shabanian","sequence":"first","affiliation":[{"name":"Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, 8952 Schlieren, Switzerland"},{"name":"University Heart Center, Department of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Shabanian","sequence":"additional","affiliation":[{"name":"Center for Translational and Experimental Cardiology, Department of Cardiology, University Hospital Zurich, University of Zurich, 8952 Schlieren, Switzerland"},{"name":"University Heart Center, Department of Cardiology, University Hospital Zurich, 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo Da","family":"Dalt","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, Universit\u00e0 Degli Studi di Milano, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Colucci","sequence":"additional","affiliation":[{"name":"Institute of Oncology Research (IOR), CH6500 Bellinzona, Switzerland"},{"name":"Universit\u00e0 della Svizzera Italiana, CH6900 Lugano, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Research Institute for Health Sciences and Technologies (SABITA), Istanbul Medipol University, Istanbul 34810, T\u00fcrkiye"},{"name":"Molecular Biology, Genetics, and Bioengineering Program, Sabanci University, Istanbul 34956, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Rodriguez Cetina Biefer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Zurich, 8091 Zurich, Switzerland"},{"name":"Department for Cardiac Surgery, City Hospital Zurich - 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