{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:53:47Z","timestamp":1777571627421,"version":"3.51.4"},"reference-count":0,"publisher":"Caleo","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Endod J"],"abstract":"<jats:p>Aim: This randomised clinical study assessed and compared the healing outcomes, both clinical and radiographic, of platelet-rich fibrin (PRF) and human amniotic membrane (HAM) scaffolds in regenerative endodontic therapy for necrotic mature permanent teeth with apical periodontitis.\r\nMethodology: The study protocol was registered on the Clinical Trial Registry (CTRI\/2023\/12\/060979). Thirty participants presenting with necrotic mature permanent teeth and apical lesions were assigned to either the PRF or HAM group (n=15 each) randomly. Follow-up evaluations were performed at baseline, 6 months, and 12 months, with clinical assessments and periapical radiographs conducted at all 3 time points, while cone-beam computed tomography (CBCT) imaging was obtained at baseline and at 12 months. Standardised regenerative endodontic procedures were performed by a single operator. Examiner calibration was completed prior to data collection to ensure consistency in measurements.\r\nResults: At the 12-month follow-up, both groups demonstrated favourable clinical outcomes, with resolution of symptoms and radiographic evidence of periapical healing. The CBCT analysis revealed significant reductions in lesion volume for both PRF (65.26%) and HAM (64.75%) groups (P &lt; .005), without a statistically significant difference between the groups. Periapical healing scores improved similarly in both groups. Sensibility tests revealed no return of pulp responsiveness in any case throughout the study period.\r\nConclusion: Both PRF and HAM scaffolds supported periapical healing in necrotic mature permanent teeth. However, biological regeneration of the functional pulp-dentin complex could not be confirmed, indicating that periapical healing occurred without verified neurovascular re-establishment. The restricted sample size and limited follow-up duration suggest the need for further studies with larger populations and extended observation periods to substantiate these findings.<\/jats:p>","DOI":"10.65717\/eej.2026.25116","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:53:55Z","timestamp":1773831235000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Comparing 2 Different Scaffolds in Regenerative Endodontics of Mature Teeth with Apical Periodontitis: A Randomised Clinical Trial"],"prefix":"10.65717","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-3388","authenticated-orcid":false,"given":"Neelam","family":"Mittal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-4933","authenticated-orcid":false,"given":"Harakh Chand","family":"Baranwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5660-1671","authenticated-orcid":false,"given":"Burugupalli","family":"Swetha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2930-6525","authenticated-orcid":false,"given":"Vijul","family":"Vijul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1978-0287","authenticated-orcid":false,"given":"Mohammad Faisal","family":"Azeez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5240-285X","authenticated-orcid":false,"given":"Gracemol","family":"Raju","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2026,2,11]]},"container-title":["European Endodontic Journal"],"original-title":[],"link":[{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/download\/371\/372","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/download\/371\/372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:53:56Z","timestamp":1773831236000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/view\/371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2,13]]}},"URL":"https:\/\/doi.org\/10.65717\/eej.2026.25116","relation":{},"ISSN":["2548-0839"],"issn-type":[{"value":"2548-0839","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}