{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:02:05Z","timestamp":1775570525228,"version":"3.50.1"},"reference-count":0,"publisher":"Caleo","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Endod J"],"abstract":"<jats:p>Objective: To evaluate periapical healing at a 6-month follow-up after single-visit endodontic treatment using 3 commonly employed sealers\u2014zinc oxide\u2013eugenol (C-Gross), epoxy resin-based (AH Plus), and calcium silicate-based (Bio-C Sealer)\u2014assessed through 3-dimensional cone-beam computed tomography (CBCT) volumetric analysis.\r\nMethods: A comparative, parallel, non-randomised, double-blinded clinical design was used. Seventy-five patients with pulp necrosis and chronic apical periodontitis were enrolled; 70 completed follow-up (AH Plus:n=25; Bio-C: n=23; C-Gross: n=22). Treatments were performed by 10 supervised postgraduate operators following a standardised protocol. Preoperative and 6-month CBCT scans were segmented by 2 calibrated, blinded radiologists (\u03ba = 0.90). Lesion volumes were obtained using manual boundary tracing and automated 3D reconstruction. Intragroup and intergroup comparisons were evaluated using non-parametric statistics.\r\nResults: All 3 sealers showed significant intragroup reductions in lesion volume over 6 months (P &lt; .001). Median volumes decreased from 81.0 to 15.0 mm3 (AH Plus), 63.0 to 12.0 mm3 (Bio-C), and 36.0 to 4.5 mm3 (C-Gross). Percentage reductions were similarly high across groups (median 79.7%-84.9%). No significant differences were observed among sealers for absolute volumetric change (P=.096) or percentage reduction (P=.912).\r\nConclusions: Periapical healing was comparable across AH Plus: n=25; Bio-C: n=23; C-Gross: n=22. When disinfection, 3-dimensional obturation, and coronal sealing are optimally achieved, sealer composition has minimal influence on tissue repair. Healing appears primarily host-driven, governed by inflammatory resolution and bone remodelling rather than sealer-derived bioactivity.<\/jats:p>","DOI":"10.65717\/eej.2026.25190","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T13:13:12Z","timestamp":1775567592000},"page":"129-139","source":"Crossref","is-referenced-by-count":0,"title":["Six-month 3-dimensional Cone-Beam Computed Tomography Assessment of Periapical Healing After Conventional Endodontic Treatment with 3 Different Endodontic Sealers: A Comparative Prospective Clinical Trial"],"prefix":"10.65717","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6675-6789","authenticated-orcid":false,"given":"Nestor","family":"Rios-Osorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0407-9847","authenticated-orcid":false,"given":"Javier","family":"Caviedes-Bucheli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6274-1865","authenticated-orcid":false,"given":"Rafael","family":"Fernandez-Grisales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2968-9745","authenticated-orcid":false,"given":"Lauren","family":"Barahona Pascua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5995-1358","authenticated-orcid":false,"given":"Juan Pablo","family":"Hurtado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1431-8373","authenticated-orcid":false,"given":"Melissa Cabezas","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6152-7055","authenticated-orcid":false,"given":"Jesus","family":"Montenegro Cuello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6552-8014","authenticated-orcid":false,"given":"Jenny","family":"Mu\u00f1oz Simbaqueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0700-6795","authenticated-orcid":false,"given":"Maria Rivera","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3748-5940","authenticated-orcid":false,"given":"Linette Rodriguez","family":"Cuellar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7021-723X","authenticated-orcid":false,"given":"Valentina Serna","family":"Correa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6459-6147","authenticated-orcid":false,"given":"Karl Seidel","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1749-7187","authenticated-orcid":false,"given":"Monica Toro","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4327-4242","authenticated-orcid":false,"given":"Hernan Dario","family":"Mu\u00f1oz\u2013alvear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"55248","published-online":{"date-parts":[[2026,3,30]]},"container-title":["European Endodontic Journal"],"original-title":[],"link":[{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/download\/391\/391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/download\/391\/391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T13:13:12Z","timestamp":1775567592000},"score":1,"resource":{"primary":{"URL":"https:\/\/eurendodj.com\/index.php\/pub\/article\/view\/391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,4,2]]}},"URL":"https:\/\/doi.org\/10.65717\/eej.2026.25190","relation":{},"ISSN":["2548-0839"],"issn-type":[{"value":"2548-0839","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,30]]}}}