{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:07:01Z","timestamp":1790021221852,"version":"4.0.1"},"reference-count":0,"publisher":"Caleo","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Int Adv Otol"],"abstract":"<jats:p>BACKGROUND: To report the first documented case of complete resolution of refractory dilatory Eustachian tube dysfunction (ETD) following dupilumab treatment in patients with severe chronic rhinosinusitis with nasal polyposis (CRSwNP).\r\nMETHODS: Four consecutive patients with longstanding refractory dilatory ETD, severe CRSwNP, and asthma, unresponsive to multiple sinus and mastoid surgeries, were treated with dupilumab.\r\nRESULTS: Dupilumab resulted in complete remission of both CRSwNP and dilatory ETD symptoms within 6 weeks. Audiometry and tubomanometry confirmed restoration of middle ear function.\r\nCONCLUSION: Dupilumab may offer a novel therapeutic option for patients with dilatory ETD associated with type 2 inflammation. Further prospective studies are needed to assess its long-term efficacy.<\/jats:p>","DOI":"10.65717\/iao.2026.252071","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:21:47Z","timestamp":1790018507000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Dupilumab as a Therapeutic Option in Chronic Eustachian Tube Dysfunction and Chronic Rhinosinusitis with Nasal Polyposis: A Case-Based Observation"],"prefix":"10.65717","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-5645","authenticated-orcid":false,"given":"Holger","family":"Sudhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55248","published-online":{"date-parts":[[2026,9,21]]},"container-title":["The Journal of International Advanced Otology"],"original-title":[],"link":[{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/2022\/2130","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/download\/2022\/2130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:21:48Z","timestamp":1790018508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.advancedotology.org\/index.php\/pub\/article\/view\/2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,9,21]]}},"URL":"https:\/\/doi.org\/10.65717\/iao.2026.252071","relation":{},"ISSN":["2148-3817"],"issn-type":[{"value":"2148-3817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}