{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:49:44Z","timestamp":1792388984102,"version":"4.4.0"},"reference-count":0,"publisher":"L\u00e4kartidningen F\u00f6rlag AB","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Kraniofaryngiom \u00e4r en ovanlig prim\u00e4r hj\u00e4rntum\u00f6r som uppst\u00e5r i den suprasell\u00e4ra regionen i rester fr\u00e5n Rathkes ficka.\nKraniofaryngiom infiltrerar omkringliggande omr\u00e5den s\u00e5som hypotalamus, hypofys och synbanan och kan resultera i synp\u00e5verkan, panhypopituitarism, kognitiva problem och uttalad obesitas.\nPapill\u00e4ra kraniofaryngiom har till 90 procent en BRAF V600E-mutation och kan framg\u00e5ngsrikt behandlas med kombinationen BRAF- och MEK-h\u00e4mmare.\nPatienter med papill\u00e4ra kraniofaryngiom med BRAF V600E-mutation som har tum\u00f6r i anslutning till hypo\u00adtalamus b\u00f6r bed\u00f6mas avseende behandling med BRAF- och MEK-h\u00e4mmare.<\/jats:p>","DOI":"10.65868\/syff9630","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:35:45Z","timestamp":1792388145000},"source":"Crossref","is-referenced-by-count":0,"title":["BRAF- och MEK- h\u00e4mmare vid papill\u00e4ra kraniofaryngiom"],"prefix":"10.65868","author":[{"given":"Eva Marie","family":"Erfurth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Siesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia C","family":"Sundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Hammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Kinhult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"55417","published-online":{"date-parts":[[2026,10,16]]},"container-title":["L\u00e4kartidningen"],"original-title":[],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:35:45Z","timestamp":1792388145000},"score":1,"resource":{"primary":{"URL":"https:\/\/lakartidningen.se\/vetenskap\/braf-och-mek-hammare-vid-papillara-kraniofaryngiom\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":0,"URL":"https:\/\/doi.org\/10.65868\/syff9630","relation":{},"ISSN":["0023-7205","1652-7518"],"issn-type":[{"value":"0023-7205","type":"print"},{"value":"1652-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"article-number":"2026;123:26008"}}