{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T23:04:52Z","timestamp":1784243092645,"version":"3.55.0"},"reference-count":0,"publisher":"Association of Paediatric Surgeons of Nigeria","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["afr j paedsurg"],"abstract":"<jats:p>Background: Majority of patients with biliary atresia (BA), including those who undergo Kasai hepatico\u2011portoenterostomy, develop cirrhosis, hepatic fibrosis and eventually progress to end\u2011stage liver disease. Therefore, early assessment of hepatic status and fibrosis is essential. The study objective was to estimate serum adiponectin, liver function tests and to associate them with liver stiffness scores in post\u2011operative BA patients. Materials and Methods: A total of 30children (20 post\u2011Kasai BA cases and 10 healthy controls) were enrolled in this prospective case\u2013control study. Serum adiponectin was measured by enzyme\u2011linked immunosorbent assay, and hepatic fibrosis by transient elastography (TE) (FibroScan). The BA patients were further divided into two groups: a jaundiced group (total bilirubin [TB] \u22652 mg\/dl) and a non\u2011jaundiced group (TB &lt;2 mg\/dl). Comparison of biomarkers was also done in these subgroups and controls by Kruskal\u2013Wallis test. Results: Adiponectin levels were significantly higher in BA cases than controls (median and interquartile range: 27.4 and 14.7 vs. 3.65 and 3.45 mg\/ml, P = 0.001). Liver stiffness values in BA patients were also markedly more than controls (9.95 and 5.45 vs. 4.60 and 4.48 kPa, P = 0.002). Furthermore, serum adiponectin and liver stiffness scores were considerably higher in cases with jaundice in comparison to non\u2011jaundiced cases (P = 0.013 and 0.001, respectively). Serum adiponectin revealed a positive correlation with TB (r = 0.81, P &lt; 0.00001) and FibroScan status (r = 0.96, P &lt; 0.00001). Conclusion: The estimation of adiponectin levels and TE can be considered to be novel non\u2011invasive methods to monitor post\u2011Kasai hepatic status in BA patients.\r\nKeywords: Kasai hepatico\u2011portoenterostomy, liver fibrosis, transient elastography<\/jats:p>","DOI":"10.67481\/ajps.v22i3.1257","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:57:26Z","timestamp":1784217446000},"page":"127-132","source":"Crossref","is-referenced-by-count":0,"title":["Serum Adiponectin and Fibroscan as Non\u2011invasive Post\u2011operative Prognostic Markers for Biliary Atresia"],"prefix":"10.67481","volume":"22","author":[{"given":"Sukanti","family":"Majhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep Kumar","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanta Kumar","family":"Tripathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parsuram","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushanta Kumar","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"57241","published-online":{"date-parts":[[2026,7,13]]},"container-title":["African Journal of Paediatric Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.afrjpaedsurg.com\/index.php\/ajps\/article\/download\/1257\/1062","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.afrjpaedsurg.com\/index.php\/ajps\/article\/download\/1257\/1062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:10:35Z","timestamp":1784239835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.afrjpaedsurg.com\/index.php\/ajps\/article\/view\/1257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,7,13]]}},"URL":"https:\/\/doi.org\/10.67481\/ajps.v22i3.1257","relation":{},"ISSN":["0974-5998","0189-6725"],"issn-type":[{"value":"0974-5998","type":"electronic"},{"value":"0189-6725","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}