{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:16:38Z","timestamp":1785449798799,"version":"3.56.0"},"reference-count":39,"publisher":"SCIE Publishing Limited","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.70322\/jrbtm.2025.10002","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T04:08:30Z","timestamp":1742875710000},"page":"10002-10002","source":"Crossref","is-referenced-by-count":3,"title":["USP11 Promotes Endothelial Apoptosis-Resistance in Pulmonary Arterial Hypertension by Deubiquitinating HINT3"],"prefix":"10.70322","volume":"2","author":[{"given":"Bum-Yong","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwoong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"S. Stearman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbur","family":"A. Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viranuj","family":"Sueblinvong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"T. Kopp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"J. Passineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"J. Benza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"J. Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51073","reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. Galie N, Manes A, Negro L, Palazzini M, Bacchi-Reggiani ML, Branzi A. A meta-analysis of randomized controlled trials in pulmonary arterial hypertension. Eur. Heart J. 2009, 30, 394-403.","DOI":"10.1093\/eurheartj\/ehp022"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"2. Lilienfeld DE, Rubin LJ. Mortality from primary pulmonary hypertension in the United States, 1979-1996. Chest 2000, 117, 796-800.","DOI":"10.1378\/chest.117.3.796"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowka M, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur. Respir. J. 2019, 24, 53.","DOI":"10.1183\/13993003.01913-2018"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. Benza RL, Miller DP, Barst RJ, Badesch DB, Frost AE, McGoon MD. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest 2012, 142, 448-456.","DOI":"10.1378\/chest.11-1460"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. Badesch DB, Raskob GE, Elliott CG, Krichman AM, Farber HW, Frost AE, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest 2010, 137, 376-387.","DOI":"10.1378\/chest.09-1140"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. McGoon MD, Krichman A, Farber HW, Barst RJ, Raskob GE, Liou TG, et al. Design of the REVEAL registry for US patients with pulmonary arterial hypertension. Mayo. Clin. Proc. 2008, 83, 923-931.","DOI":"10.1016\/S0025-6196(11)60769-6"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. Chen M, Ding Z, Zhang F, Shen H, Zhu L, Yang H, et al. A20 attenuates hypoxia-induced pulmonary arterial hypertension by inhibiting NF-kappaB activation and pulmonary artery smooth muscle cell proliferation. Exp. Cell. Res. 2020, 390, 111982.","DOI":"10.1016\/j.yexcr.2020.111982"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. Hao X, Ma C, Chen S, Dang J, Cheng X, Zhu D. Reverse the down regulation of miR-92b-3p by hypoxia can suppress the proliferation of pulmonary artery smooth muscle cells by targeting USP28. Biochem. Biophys. Res. Commun. 2018, 503, 3064-3077.","DOI":"10.1016\/j.bbrc.2018.08.095"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. Koudstaal T, van Hulst JAC, Das T, Neys SFH, Merkus D, Bergen IM, et al. DNGR1-Cre-mediated Deletion of Tnfaip3\/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice. Am. J. Respir. Cell. Mol. Biol. 2020, 63, 665-680.","DOI":"10.1165\/rcmb.2019-0443OC"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. Zhang W, Qi Y, Wu B. MicroRNA-146-5p Promotes Pulmonary Artery Endothelial Cell Proliferation under Hypoxic Conditions through Regulating USP3. Dis. Mark. 2021, 2021, 3668422.","DOI":"10.1155\/2021\/3668422"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"11. Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, et al. The deubiquitinase USP11 is a versatile and conserved regulator of autophagy. J. Biol. Chem. 2021, 297, 101263.","DOI":"10.1016\/j.jbc.2021.101263"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"12. Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W, et al. The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2. Oncogene 2021, 40, 1706-1720.","DOI":"10.1038\/s41388-021-01660-5"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"13. Zhang X, Liu T, Xu S, Gao P, Dong W, Liu W, et al. A pro-inflammatory mediator USP11 enhances the stability of p53 and inhibits KLF2 in intracerebral hemorrhage. Mol. Ther. Methods Clin. Dev. 2021, 21, 681-692.","DOI":"10.1016\/j.omtm.2021.01.015"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"14. Zhu X, Zhang Y, Luo Q, Wu X, Huang F, Shu T, et al. The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP. Signal. Transduct. Target. Ther. 2021, 6, 264.","DOI":"10.1038\/s41392-021-00580-w"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"15. Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, et al. Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome. Am. J. Respir. Cell. Mol. Biol. 2019, 60, 637-649.","DOI":"10.1165\/rcmb.2018-0368OC"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"16. Benza RL, Gomberg-Maitland M, Demarco T, Frost AE, Torbicki A, Langleben D, et al. Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2015, 192, 1345-1354.","DOI":"10.1164\/rccm.201501-0196OC"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"17. Bhagwani AR, Farkas D, Harmon B, Authelet KJ, Cool CD, Kolb M, et al. Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxia. Sci. Rep. 2020, 10, 1136.","DOI":"10.1038\/s41598-020-58083-7"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"18. Macias D, Moore S, Crosby A, Southwood M, Du X, Tan H, et al. Targeting HIF2alpha-ARNT hetero-dimerisation as a novel therapeutic strategy for pulmonary arterial hypertension. Eur. Respir. J. 2021, 4, 57.","DOI":"10.1183\/13993003.02061-2019"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"19. Van der Feen DE, Kurakula K, Tremblay E, Boucherat O, Bossers GPL, Szulcek R, et al. Multicenter Preclinical Validation of BET Inhibition for the Treatment of Pulmonary Arterial Hypertension. Am. J. Respir. Crit. Care Med. 2019, 200, 910-920.","DOI":"10.1164\/rccm.201812-2275OC"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"20. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer. 2002, 2, 647-656.","DOI":"10.1038\/nrc883"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"21. Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes or mitochondria? Genes Cells. 1998, 3, 697-707.","DOI":"10.1046\/j.1365-2443.1998.00223.x"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"22. Antico Arciuch VG, Elguero ME, Poderoso JJ, Carreras MC. Mitochondrial regulation of cell cycle and proliferation. Antioxid. Redox. Signal. 2012, 16, 1150-1180.","DOI":"10.1089\/ars.2011.4085"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"23. Benza RL, Williams G, Wu C, Shields KJ, Raina A, Murali S, et al. In situ expression of Bcl-2 in pulmonary artery endothelial cells associates with pulmonary arterial hypertension relative to heart failure with preserved ejection fraction. Pulm. Circ. 2016, 6, 551-556.","DOI":"10.1086\/688774"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"24. Kang BY, Park KK, Kleinhenz JM, Murphy TC, Green DE, Bijli KM, et al. Peroxisome Proliferator-Activated Receptor gamma and microRNA 98 in Hypoxia-Induced Endothelin-1 Signaling. Am. J. Respir. Cell. Mol. Biol. 2016, 54, 136-146.","DOI":"10.1165\/rcmb.2014-0337OC"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"25. Wang D, Zhao J, Li S, Wei J, Nan L, Mallampalli RK, et al. Phosphorylated E2F1 is stabilized by nuclear USP11 to drive Peg10 gene expression and activate lung epithelial cells. J. Mol. Cell. Biol. 2018, 10, 60-73.","DOI":"10.1093\/jmcb\/mjx034"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"26. Bellosillo B, Colomer D, Pons G, Gil J. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br. J. Haematol. 1998, 100, 142-146. doi:10.1046\/j.1365-2141.1998.00520.x","DOI":"10.1046\/j.1365-2141.1998.00520.x"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"27. Cao Y, Jiang Z, Zeng Z, Liu Y, Gu Y, Ji Y, et al. Bcl-2 silencing attenuates hypoxia-induced apoptosis resistance in pulmonary microvascular endothelial cells. Apoptosis 2016, 21, 69-84.","DOI":"10.1007\/s10495-015-1184-3"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"28. Hu CJ, Zhang H, Laux A, Pullamsetti SS, Stenmark KR. Mechanisms contributing to persistently activated cell phenotypes in pulmonary hypertension. J. Physiol. 2019, 597, 1103-1119.","DOI":"10.1113\/JP275857"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"29. Wolberger C. Mechanisms for regulating deubiquitinating enzymes. Prot. Sci. 2014, 23, 344-353.","DOI":"10.1002\/pro.2415"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"30. Hochstrasser M. Biochemistry. All in the ubiquitin family. Science 2000, 289, 563-564.","DOI":"10.1126\/science.289.5479.563"},{"key":"ref30","doi-asserted-by":"publisher","unstructured":"31. Bakhshi FR, Mao M, Shajahan AN, Piegeler T, Chen Z, Chernaya O, et al. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulm. Circ. 2013, 3, 816-830.","DOI":"10.1086\/674753"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"32. Schultz A, Olorundami OA, Teng RJ, Jarzembowski J, Shi ZZ, Kumar SN, et al. Decreased OLA1 (Obg-Like ATPase-1) Expression Drives Ubiquitin-Proteasome Pathways to Downregulate Mitochondrial SOD2 (Superoxide Dismutase) in Persistent Pulmonary Hypertension of the Newborn. Hypertension 2019, 74, 957-966.","DOI":"10.1161\/HYPERTENSIONAHA.119.13430"},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"33. Shen H, Zhang J, Wang C, Jain PP, Xiong M, Shi X, et al. MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension. Circulation 2020, 142, 1190-1204.","DOI":"10.1161\/CIRCULATIONAHA.120.048191"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"34. Wu Z, Zhu L, Nie X, Wei L, Qi Y. USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1\/TAZ-dependent manner. Exp. Mol. Med. 2023, 55, 183-195. doi:10.1038\/s12276-022-00920-y","DOI":"10.1038\/s12276-022-00920-y"},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"35. Tang H, Gupta A, Morrisroe SA, Bao C, Schwantes-An TH, Gupta G, et al. Deficiency of the Deubiquitinase UCHL1 Attenuates Pulmonary Arterial Hypertension. Circulation 2024, 150, 302-316. doi:10.1161\/CIRCULATIONAHA.123.065304.","DOI":"10.1161\/CIRCULATIONAHA.123.065304"},{"key":"ref35","doi-asserted-by":"publisher","unstructured":"36. Wade BE, Zhao J, Ma J, Hart CM, Sutliff RL. Hypoxia-induced alterations in the lung ubiquitin proteasome system during pulmonary hypertension pathogenesis. Pulm. Circ. 2018, 8, 2045894018788267.","DOI":"10.1177\/2045894018788267"},{"key":"ref36","unstructured":"37. Uhlen M, Fagerberg L, Hallstrom BM, Lindskog C, Oksvold P, Mardinoglu A, et al. Proteomics. Tissue-based map of the human proteome. Science 2015, 347, 1260419."},{"key":"ref37","doi-asserted-by":"publisher","unstructured":"38. Wang W, Xu G, Ding CL, Zhao LJ, Zhao P, Ren H, et al. All-trans retinoic acid protects hepatocellular carcinoma cells against serum-starvation-induced cell death by upregulating collagen 8A2. FEBS J. 2013, 280, 1308-1319.","DOI":"10.1111\/febs.12122"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"39. Burkhart RA, Peng Y, Norris ZA, Tholey RM, Talbott VA, Liang Q, et al. Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival. Mol. Cancer. Res. 2013, 11, 901-911.","DOI":"10.1158\/1541-7786.MCR-12-0699"}],"container-title":["Journal of Respiratory Biology and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.sciepublish.com\/article\/pii\/470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T02:04:15Z","timestamp":1743473055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.sciepublish.com\/article\/pii\/470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.70322\/jrbtm.2025.10002","relation":{},"ISSN":["3006-6514"],"issn-type":[{"value":"3006-6514","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}