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Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2023; 401: 1853\u201365.","DOI":"10.1016\/S0140-6736(23)00727-4"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Nakamura H, Arai Y, Totoki Y, et al. Genomic spectra of biliary tract cancer. Nat Genet 2015; 47: 1003\u201310.","DOI":"10.1038\/ng.3375"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Farmer H, McCabe N, Lord CJ, et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917\u201321.","DOI":"10.1038\/nature03445"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Nakachi K, Ikeda M, Konishi M, et al. Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial. 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