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J Med Case Rep 2021; 15: 500.","DOI":"10.1186\/s13256-021-03094-9"},{"key":"5","unstructured":"5) Ladanyi M, Gerald W. Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor. Cancer Res 1994; 54: 2837\u201340."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Gerald WL, Rosai J. Case 2. Desmoplastic small cell tumor with divergent differentiation. Pediatr Pathol 1989; 9: 177\u201383.","DOI":"10.3109\/15513818909022347"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Gerald WL, Miller HK, Battifora H, et al. Intra-abdominal desmoplastic small round-cell tumor. Report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals. Am J Surg Pathol 1991; 15: 499\u2013513.","DOI":"10.1097\/00000478-199106000-00001"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Magrath JW, Kang HG, Hartono A, et al. Desmoplastic small round cell tumor cancer stem cell-like cells resist chemotherapy but remain dependent on the EWSR1-WT1 oncoprotein. Front Cell Dev Biol 2022; 10: 1048709.","DOI":"10.3389\/fcell.2022.1048709"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Gedminas JM, Chasse MH, McBrairty M, et al. Desmoplastic small round cell tumor is dependent on the EWS-WT1 transcription factor. Oncogenesis 2020; 9: 41.","DOI":"10.1038\/s41389-020-0224-1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Gerald WL, Ladanyi M, de Alava E, et al. Clinical, pathologic, and molecular spectrum of tumors associated with t(11;22)(p13;q12): desmoplastic small round-cell tumor and its variants. J Clin Oncol 1998; 16: 3028\u201336.","DOI":"10.1200\/JCO.1998.16.9.3028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Tian Y, Cheng X, Li Y. Chemotherapy combined with apatinib for the treatment of desmoplastic small round cell tumors: a case report. J Cancer Res Ther 2020; 16: 1177\u201381.","DOI":"10.4103\/jcrt.JCRT_589_20"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Lee YS, Hsiao CH. Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical and molecular study of four patients. J Formos Med Assoc 2007; 106: 854\u201360.","DOI":"10.1016\/S0929-6646(08)60051-0"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Ofori E, Ramai D, Nigar S, et al. Desmoplastic small round cell tumor: a rare case of extraluminal bowel obstruction and review of the literature. J Gastrointest Cancer. 2019; 50: 560\u20133.","DOI":"10.1007\/s12029-017-0045-4"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hayes-Jordan A, LaQuaglia MP, Modak S. Management of desmoplastic small round cell tumor. Semin Pediatr Surg 2016; 25: 299\u2013304.","DOI":"10.1053\/j.sempedsurg.2016.09.005"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Lal DR, Su WT, Wolden SL, et al. Results of multimodal treatment for desmoplastic small round cell tumors. J Pediatr Surg 2005; 40: 251\u20135.","DOI":"10.1016\/j.jpedsurg.2004.09.046"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Altal OF, Aleshawi AJ, Tashtush NA, et al. A 23-year-old Joradanian woman with a desmoplastic small round cell tumor involving the ovary. Am J Case Rep 2019; 20: 1675\u20138.","DOI":"10.12659\/AJCR.919488"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sawyer JR, Tryka AF, Lewis JM. A novel reciprocal chromosome translocation t(11;22)(p13;q12) in an intraabdominal desmoplastic small round-cell tumor. Am J Surg Pathol 1992; 16: 411\u20136.","DOI":"10.1097\/00000478-199204000-00010"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Zhang WD, Li C, Liu Q, et al. CT, MRI, and FDG-PET\/CT imaging findings of abdominopelvic desmoplastic small round cell tumors: correlation with histopathologic findings. Eur J Radiol 2011; 80: 269\u201373.","DOI":"10.1016\/j.ejrad.2010.06.046"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Morani AC, Bathala TK, Surabhi VR, et al. Desmoplastic small round cell tumor: imaging pattern of disease at presentation. AJR Am J Roentgenol 2019; 212: W45\u201354.","DOI":"10.2214\/AJR.18.20179"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Xuesong D, Hong G, Weiguo Z. Primary desmoplastic small round cell tumor of the tibia: PET\/CT and MRI presentation of a rare case and review of the literature. J Bone Oncol 2019; 20: 100272.","DOI":"10.1016\/j.jbo.2019.100272"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Thway K, Noujaim J, Zaidi S, et al. Desmoplastic small round cell tumor: pathology, genetics, and potential therapeutic strategies. Int J Surg Pathol 2016; 24: 672\u201384.","DOI":"10.1177\/1066896916668637"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Celso AM, Fernando ABC, Tiago GS, et al. Desmoplastic small round cell tumor: a review of main molecular abnormalities and emerging therapy. Cancers (Basel) 2021; 28;13: 498.","DOI":"10.3390\/cancers13030498"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Li R, Liu W, Ye L. Desmoplastic small round cell tumor of the abdomen: a case report. Medicine (Baltimore) 2023; 102: e35965.","DOI":"10.1097\/MD.0000000000035965"},{"key":"24","unstructured":"24) Trupiano JK, Machen SK, Barr FG, et al. Cytokeratin-negative desmoplastic small round cell tumor: a report of two cases emphasizing the utility of reverse transcriptase-polymerase chain reaction. Mod Pathol 1999; 12: 849\u201353."},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Lee SB, Kolquist KA, Nichols K, et al. The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour. 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Desmoplastic small round cell tumour: characteristics and prognostic factors of 41 patients and review of the literature. Clin Sarcoma Res 2013; 3: 14.","DOI":"10.1186\/2045-3329-3-14"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) Kushner BH, LaQuaglia MP, Wollner N, et al. Desmoplastic small round-cell tumor: prolonged progression-free survival with aggressive multimodality therapy. J Clin Oncol 1996; 14: 1526\u201331.","DOI":"10.1200\/JCO.1996.14.5.1526"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Honore C, Atallah V, Mir O, et al. Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: Is there a benefit for HIPEC after macroscopically complete cytoreductive surgery? PLoS One 2017; 24: 12.","DOI":"10.1371\/journal.pone.0171639"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Reijers SJM, Siew CCH, Kok NFM, et al. Intra-abdominal Desmoplastic small round cell tumor (DSRCT) and the role of hyperthermic intraperitoneal chemotherapy (HIPEC): a review. Curr Oncol 2023; 30: 3951\u201363.","DOI":"10.3390\/curroncol30040299"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36) Loktev A, Shipley JM. Desmoplastic small round cell tumor (DSRCT): emerging therapeutic targets and future directions for potential therapies. Expert Opin Ther Targets 2020; 24: 281\u20135.","DOI":"10.1080\/14728222.2020.1738392"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37) Modak S, Gerald W, Cheung N-KV. Disialoganglioside GD2 and a novel tumor antigen: potential targets for immunotherapy of desmoplastic small round cell tumor. Med Pediatr Oncol 2002; 39: 547\u201351.","DOI":"10.1002\/mpo.10151"},{"key":"38","unstructured":"38) Modak S, Kramer K, Gultekin SH, et al. Monoclonal antibody 8H9 targets a novel cell surface antigen expressed by a wide spectrum of human solid tumors. Cancer Res 2001; 61: 4048\u201354."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Menegaz BA, Cuglievan B, Benson J, et al. Clinical activity of pazopanib in patients with advanced desmoplastic small round cell tumor. Oncologist 2018; 23: 360\u20136.","DOI":"10.1634\/theoncologist.2017-0408"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Anderson PM, Trucco MM, Tarapore RS, et al. Phase II Study of ONC201 in neuroendocrine tumors including pheochromocytomaparaganglioma and desmoplastic small round cell tumor. Clin Cancer Res 2022; 28: 1773\u201382.","DOI":"10.1158\/1078-0432.CCR-21-4030"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41) Modak S, Zanzonico P, Grkovski M, et al. B7H3-directed intraperitoneal radioimmunotherapy with radioiodinated omburtamab for desmoplastic small round cell tumor and other peritoneal tumors: results of a phase I study. J Clin Oncol 2020; 38: 4283\u201391.","DOI":"10.1200\/JCO.20.01974"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Lamhamedi-Cherradi SE, Maitituoheti M, Menegaz BA, et al. The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma. Nat Commun 2022; 13: 3057.","DOI":"10.1038\/s41467-022-30710-z"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Laurens JR, Frankel AJ, Smithers BM. Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: case report of a very rare presentation of an unusual tumour. Int J Surg Case Rep 2021; 79: 323\u20136.","DOI":"10.1016\/j.ijscr.2021.01.058"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44) Pahuja  AK, Mundodan MS. Whole abdominopelvic radiotherapy in desmoplastic small round cell tumour of abdomen: a challenge for radiation oncologists. BMJ Case Rep 2018; 2018: bcr-2018-224838.","DOI":"10.1136\/bcr-2018-224838"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45) Huang J, Sha L, Zhang H, et al. Desmoplastic small round cell tumor in transverse colon: report of a rare case. Int Surg 2015; 100: 809\u201313.","DOI":"10.9738\/INTSURG-D-14-00134.1"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46) Liu Q, Liu N, Chen D. Primary desmoplastic small round cell tumor of the duodenum. 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