{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:53:42Z","timestamp":1785020022162,"version":"3.55.0"},"reference-count":20,"publisher":"Japan Surgical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Case Rep"],"published-print":{"date-parts":[[2026]]},"DOI":"10.70352\/scrj.cr.25-0536","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:08:38Z","timestamp":1767823718000},"page":"n\/a","source":"Crossref","is-referenced-by-count":3,"title":["Successful Conversion Surgery after Zolbetuximab-Based Chemotherapy for Claudin 18.2-Positive Gastric Cancer with Peritoneal Dissemination and Cervical Lymph Node Metastasis: A Case Report"],"prefix":"10.70352","volume":"12","author":[{"given":"Sadaki","family":"Shirao","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Arigami","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Shimonosono","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tasaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihide","family":"Tanimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohtsuka","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Kagoshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51119","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2024; 74: 229\u201363.","DOI":"10.3322\/caac.21834"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Japanese Gastric Cancer Association. Japanese gastric cancer treatment guidelines 2021 (6th edition). Gastric Cancer 2023; 26: 1\u201325.","DOI":"10.1007\/s10120-022-01331-8"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Keam SJ. Zolbetuximab: first approval. Drugs 2024; 84: 977\u201383.","DOI":"10.1007\/s40265-024-02056-x"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Kodera Y. Surgery with curative intent for stage IV gastric cancer: is it a reality of illusion? Ann Gastroenterol Surg 2018; 2: 339\u201347.","DOI":"10.1002\/ags3.12191"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Arigami T, Matsushita D, Okubo K, et al. Clinical significance of conversion surgery for gastric cancer with peritoneal dissemination: a retrospective study. Oncology 2020; 98: 798\u2013806.","DOI":"10.1159\/000509530"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Yoshida K, Yasufuku I, Terashima M, et al. International retrospective cohort study of conversion therapy for stage IV gastric cancer 1 (CONVO-GC-1). Ann Gastroenterol Surg 2022; 6: 227\u201340.","DOI":"10.1002\/ags3.12515"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Japanese Gastric Cancer Association. Japanese classification of gastric carcinoma: 3rd English edition. Gastric Cancer 2011; 14: 101\u201312.","DOI":"10.1007\/s10120-011-0041-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Tsukita S, Furuse M. The structure and function of claudins, cell adhesion molecules at tight junctions. Ann N Y Acad Sci 2000; 915: 129\u201335.","DOI":"10.1111\/j.1749-6632.2000.tb05235.x"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Sahin U, Koslowski M, Dhaene K, et al. Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development. Clin Cancer Res 2008; 14: 7624\u201334.","DOI":"10.1158\/1078-0432.CCR-08-1547"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Kinugasa F, Kajikawa S, Weng J, et al. Effect of antiemetics on zolbetuximab-induced gastric injury and emesis in ferrets. J Pharmacol Sci 2024; 156: 161\u201370.","DOI":"10.1016\/j.jphs.2024.08.005"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Shah MA, Shitara K, Ajani JA, et al. Zolbetuximab plus CAPOX in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma: the randomized, phase 3 GLOW trial. Nat Med 2023; 29: 2133\u201341.","DOI":"10.1038\/s41591-023-02465-7"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Shitara K, Lordick F, Bang YJ, et al. Zolbetuximab plus mFOLFOX6 in patients with CLDN18.2-positive, HER2-negative, untreated, locally advanced unresectable or metastatic gastric or gastro-oesophageal junction adenocarcinoma (SPOTLIGHT): a multicentre, randomised, double-blind, phase 3 trial. Lancet 2023; 401: 1655\u201368.","DOI":"10.1016\/S0140-6736(23)00620-7"},{"key":"13","unstructured":"13) European Medicines Agency. Assessment report, Vyloy, International non-proprietary name: zolbetuximab. https:\/\/www.ema.europa.eu\/en\/documents\/assessment-report\/vyloy-epar-public-assessment-report_en.pdf. Accessed 28 July 2025."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Kim TH, Uyama I, Rha SY, et al. Conversion therapy for stage IV gastric cancer: report from the expert consensus meeting at KINGCA WEEK 2024. J Gastric Cancer 2025; 25: 133\u201352.","DOI":"10.5230\/jgc.2025.25.e9"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hidaka Y, Arigami T, Osako Y, et al. Conversion surgery for microsatellite instability-high gastric cancer with a complete pathological response to pembrolizumab: a case report. World J Surg Oncol 2022; 20: 193.","DOI":"10.1186\/s12957-022-02661-8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Katsumata K, Morimoto Y, Aoyama J, et al. Conversion surgery for gastric remnant cancer with liver metastasis after nivolumab combination chemotherapy achieving pathological complete response: a case report and literature review. Surg Case Rep 2024; 10: 107.","DOI":"10.1186\/s40792-024-01905-x"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Kakinuma H, Honda M, Kawamura H, et al. Prognostic impact of conversion surgery in patients with stage IV gastric cancer: a multicenter population-based cohort study. Surg Oncol 2025; 61: 102241.","DOI":"10.1016\/j.suronc.2025.102241"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Sugiyama Y, Tanabe H, Tachibana S, et al. Zolbetuximab-related gastritis: a case report of the patient with prolonged gastrointestinal symptoms. Gastric Cancer 2025; 28: 705\u201311.","DOI":"10.1007\/s10120-025-01607-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Yanagimoto Y, Yamamoto K, Hara K, et al. Two cases of protein-losing enteropathy induced by zolbetuximab in patients with unresectable advanced gastric cancer. Jpn J Clin Oncol 2025; 55: 825\u201331.","DOI":"10.1093\/jjco\/hyaf055"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Kita R, Yasufuku I, Takahashi N, et al. Randomized controlled phase III study comparing chemotherapy alone versus conversion surgery after a remarkable response to chemotherapy in patients with initially unresectable cStage IVB or pStage IV gastric cancer (JCOG2301, Conversion study). Jpn J Clin Oncol 2025; 55: 304\u201310.","DOI":"10.1093\/jjco\/hyae174"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.25-0536\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T04:46:43Z","timestamp":1768020403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.25-0536\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.70352\/scrj.cr.25-0536","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"cr.25-0536"}}