{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:49:14Z","timestamp":1775882954154,"version":"3.50.1"},"reference-count":43,"publisher":"Japan Surgical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Case Rep"],"published-print":{"date-parts":[[2026]]},"DOI":"10.70352\/scrj.cr.25-0777","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:08:52Z","timestamp":1775686132000},"page":"n\/a","source":"Crossref","is-referenced-by-count":0,"title":["Radiation-Associated Angiosarcoma of the Breast: A Case Report with Review of Reported Cases in Japan"],"prefix":"10.70352","volume":"12","author":[{"given":"Eri","family":"Ida","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahiro","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminao","family":"Kanehisa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momoko","family":"Komai","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Itoi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Urata","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tecchu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"51119","reference":[{"key":"1","unstructured":"1) Goldblum JR, Folpe AL, Weiss SW, editors. Enzinger and Weiss\u2019s Soft Tissue Tumors, 6th ed. Philadelphia: Elsevier; 2013."},{"key":"2","unstructured":"2) Japanese Breast Cancer Society. Breast Cancer Clinical Practice Guidelines 2022. Tokyo: Kanehara & Co., Ltd.; 2022. (in Japanese)"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Schreiber H, Barry FM, Russell WC, et al. Stewart-Treves syndrome. A lethal complication of postmastectomy lymphedema and regional immune deficiency. Arch Surg 1979; 114: 82\u20135.","DOI":"10.1001\/archsurg.1979.01370250084018"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Palta M, Morris CG, Grobmyer SR, et al. Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy. Cancer 2010; 116: 1872\u20138.","DOI":"10.1002\/cncr.24995"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Ishizuka Y, Horimoto Y, Onagi H, et al. Microsatellite-stable radiation-induced angiosarcoma after breast-conserving surgery: a case report. Case Rep Oncol 2020; 13: 1275\u201380.","DOI":"10.1159\/000510809"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Yonekawa Y, Asaba Y, Maeta T, et al. Radiation-associated breast angiosarcoma\u2014a case report\u2014. Nihon Rinsho Geka Gakkai Zasshi 2022; 83: 1221\u20138. (in Japanese)","DOI":"10.3919\/jjsa.83.1221"},{"key":"7","unstructured":"7) Kimura R, Tsukamoto F, Miyamoto K, et al. Angiosarcoma of the breast following breast-conserving surgery with radiotherapy for breast cancer.: report of two cases. Jpn J Breast Cancer 2014; 29: 433\u201341. (in Japanese)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Yasuoka R, Hanioka K, Mitsuo M. A patient with angiosarcoma of the breast after breast-conserving surgery and radiotherapy for breast cancer. Nihon Rinsho Geka Gakkai Zasshi 2014; 75: 2976\u201381. (in Japanese)","DOI":"10.3919\/jjsa.75.2976"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Todoroki H, Shimada K, Tsutsumi N, et al. A case of radiation-induced breast angiosarcoma that developed following breast-conserving surgery. Nihon Rinsho Geka Gakkai Zasshi 2014; 75: 2125\u20139. (in Japanese)","DOI":"10.3919\/jjsa.75.2125"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Mizumoto S, Konishi S, Minohata J, et al. A case of radiation-induced breast angiosarcoma following breast-conserving surgery. Nihon Rinsho Geka Gakkai Zasshi 2014; 75: 889\u201394. (in Japanese)","DOI":"10.3919\/jjsa.75.889"},{"key":"11","unstructured":"11) Hojo S, Yoshioka S, Toyoda Y, et al. Two cases of radiotherapy-induced sarcoma after breast cancer surgery. Gan To Kagaku Ryoho 2014; 41: 1909\u201311. (in Japanese)"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ogata T, Kudo S, Makino T, et al. A case of radiation-induced angiosarcoma after conservative treatment for breast cancer. Nihon Rinsho Geka Gakkai Zasshi 2014; 75: 648\u201351. (in Japanese)","DOI":"10.3919\/jjsa.75.648"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Tajima S, Mochizuki R, Sugimura H, et al. Radiation-induced breast angiosarcoma with a confirmative feature of c-MYC amplification. Jpn J Clin Oncol 2014; 44: 702\u20133.","DOI":"10.1093\/jjco\/hyu064"},{"key":"14","unstructured":"14) Oda M, Arihiro K, Kaneko Y, et al. A case of secondary angiosarcoma of the breast skin. J Hiroshima Soc Clin Cytol 2015; 36: 73\u20138."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hara N, Fujimoto N, Miyamoto Y, et al. Angiosarcoma of the thoracic wall responded well to nanoparticle albumin-bound paclitaxel: a case report. Drug Discov Ther 2016; 10: 114\u20136.","DOI":"10.5582\/ddt.2016.01005"},{"key":"16","unstructured":"16) Kobayashi K, Hagiwara Y, Kato Y, et al. Two cases of post-radiation sarcoma after treatment for breast cancer. J East Jpn Orthop Traumatol 2016; 28: 454\u20137."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Masai K, Kinoshita T, Jimbo K, et al. Clinicopathological features of breast angiosarcoma. Breast Cancer 2016; 23: 718\u201323.","DOI":"10.1007\/s12282-015-0630-y"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kanaizumi H, Hamada M, Shinzaki W, et al. Angiosarcoma developing in the skin after breast conservation therapy and radiotherapy for breast cancer\u2014two case studies\u2014. Nihon Rinsho Geka Gakkai Zasshi 2017; 78: 926\u201330. (in Japanese)","DOI":"10.3919\/jjsa.78.926"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kawasaki H, Ohmura T, Kameshiima H, et al. A case of radiation-induced breast angiosarcoma that developed after breast-conserving surgery. Nihon Gekakei Rengo Gakkai Shi 2017; 42: 743\u201351. (in Japanese)","DOI":"10.4030\/jjcs.42.743"},{"key":"20","unstructured":"20) Sawatsubashi T, Nakatsuka H, Nihei K. A case of angiosarcoma of the breast following breast-conserving surgery with radiotherapy for breast cancer. Gan To Kagaku Ryoho 2017; 44: 1428\u201330. (in Japanese)"},{"key":"21","unstructured":"21) Takamatsu Y, Ito M, Kin T, et al. Mammary angiosarcoma after breast-conserving surgery: a case report. Jpn J Breast Cancer 2018; 33: 265\u201372. (in Japanese)"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Horisawa N, Adachi Y, Sawaki M, et al. A case of radiation-associated angiosarcoma after breast cancer. Surg Case Rep 2018; 4: 131.","DOI":"10.1186\/s40792-018-0538-9"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Nomoto Y, Kijima Y, Shinden Y, et al. Two cases of radiation-associated angiosarcoma of the breast. Surg Case Rep 2018; 4: 132.","DOI":"10.1186\/s40792-018-0539-8"},{"key":"24","unstructured":"24) Tokoro T, Kaji M, Maeda K, et al. Two cases of breast angiosarcoma occurring after breast-conserving therapy. Jpn J Breast Cancer 2019; 34: 271\u201380. (in Japanese)"},{"key":"25","unstructured":"25) Tamaoki M, Nio Y, Tamaoki M, et al. Radiation-associated angiosarcoma that developed in the irradiated residual breast after breast-conserving surgery for breast cancer. Gan To Kagaku Ryoho 2020; 47: 77\u201381. (in Japanese)"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Takada K, Miyashita M, Kawajiri H, et al. Two cases of radiation-induced breast angiosarcoma after breast-conserving surgery. Nihon Rinsho Geka Gakkai Zasshi 2020; 81: 36\u201340. (in Japanese)","DOI":"10.3919\/jjsa.81.36"},{"key":"27","unstructured":"27) Miyata M, Yoshida N, Ishizuka M, et al. Radiation-induced breast angiosarcoma after conservative surgery for breast cancer. Gan To Kagaku Ryoho 2020; 47: 540\u20131. (in Japanese)"},{"key":"28","unstructured":"28) Takatsuka D, Nakagami K, Yamaguchi K, et al. A case of radiation-induced cutaneous angiosarcoma after breast-conserving surgery. J Clin Surg 2020; 75: 369\u201373."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Suzuki Y, Taniguchi K, Hatono M, et al. Recurring radiation-induced angiosarcoma of the breast that was treated with paclitaxel chemotherapy: a case report. Surg Case Rep 2020; 6: 25.","DOI":"10.1186\/s40792-020-0790-7"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Shiraki E, Kang Y, Shibayama T, et al. Two cases of breast angiosarcoma after breast conserving surgery. Surg Case Rep 2020; 6: 81.","DOI":"10.1186\/s40792-020-00841-w"},{"key":"31","unstructured":"31) Mizusaki M, Kanno T, Ishii F, et al. Hidari nyuugan chiryo-go ni hassho shita kekkannikushu no ichirei. J Jpn Red Cross Takamatsu Hosp 2020; 8: 97\u2013101. (in Japanese)"},{"key":"32","unstructured":"32) Iijima K, Ishizu H, Ito R, et al. Nyubo onzon jutsu-go ni shojita hoshasen yuhatsusei kekkannikushu no ichirei. Jpn J Clin Dermatol 2022; 64: 342\u20137. (in Japanese)"},{"key":"33","unstructured":"33) Hojo Y, Noda S, Mashita Y, et al. A case of radiation-induced angiosarcoma after breast cancer. Jpn J Breast Cancer 2023; 38: 227\u201334. (in Japanese)"},{"key":"34","unstructured":"34) Watanabe S, Morita M, Arita T, et al. Two cases of breast angiosarcoma treated at our hospital. J Kyoto Pref Univ Med 2023; 132: 723\u201330. (in Japanese)"},{"key":"35","unstructured":"35) Saito T, Shoji Y, Ohashi R, et al. A case of breast angiosarcoma developing 15 years after radiotherapy for breast-conserving surgery. Jpn J Clin Exp Med 2024; 101: 1268\u201372."},{"key":"36","unstructured":"36) Ono S, Tanaka M, Yoshinaga Y, et al. Two cases of breast angiosarcoma: primary and secondary angiosarcoma. Jpn J Breast Cancer 2024; 39: 435\u201343. (in Japanese)"},{"key":"37","unstructured":"37) Yamada K, Osada M, Katchi Y, et al. Two cases of radiation-induced breast angiosarcoma after breast-conserving surgery. Gan To Kagaku Ryoho 2024; 51: 1547\u20139. (in Japanese)"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Cozzi S, Finocchi Ghersi S, Tava F, et al. Radiation-associated angiosarcoma of the breast: the state of the art of a rare and aggressive disease. J Pers Med 2024; 14: 859.","DOI":"10.3390\/jpm14080859"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Fraga-Guedes C, Andr\u00e9 S, Mastropasqua MG, et al. Angiosarcoma and atypical vascular lesions of the breast: diagnostic and prognostic role of MYC gene amplification and protein expression. Breast Cancer Res Treat 2015; 151: 131\u201340.","DOI":"10.1007\/s10549-015-3379-2"},{"key":"40","unstructured":"40) Japanese Dermatological Association, Japanese Skin Cancer Society, Guidelines Committee for Skin Cancer (Angiosarcoma Guidelines Group). Skin Cancer Clinical Practice Guidelines 4th edition, Angiosarcoma Clinical Practice Guidelines 2025. Jpn J Dermatol 2025; 135: 557\u2013603."},{"key":"41","unstructured":"41) National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Soft Tissue Sarcoma. Version 2. 2025. https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/sarcoma.pdf. Accessed 16 November 2025."},{"key":"42","doi-asserted-by":"crossref","unstructured":"42) Gronchi A, Miah AB, Dei Tos AP, et al. Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2021; 32: 1348\u201365.","DOI":"10.1016\/j.annonc.2021.07.006"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43) Takehara Y, Matsuda N, Kobayashi D, et al. Radiation-induced angiosarcoma of the breast: individual participant meta-analysis of Japanese population. Breast Cancer 2023; 30: 739\u201347.","DOI":"10.1007\/s12282-023-01466-1"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.25-0777\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:06:50Z","timestamp":1775880410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.25-0777\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.70352\/scrj.cr.25-0777","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"cr.25-0777"}}