{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:48:42Z","timestamp":1782535722531,"version":"3.54.5"},"reference-count":21,"publisher":"Japan Surgical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Case Rep"],"published-print":{"date-parts":[[2026]]},"DOI":"10.70352\/scrj.cr.26-0088","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:12:32Z","timestamp":1782511952000},"page":"n\/a","source":"Crossref","is-referenced-by-count":0,"title":["Multidisciplinary Treatment for Advanced Pancreatic Adenocarcinoma Arising from Esophageal Heterotopic Pancreas in a Young Adult: A Case Report"],"prefix":"10.70352","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0290-3156","authenticated-orcid":false,"given":"Yohei","family":"Mizusawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-3908","authenticated-orcid":false,"given":"Kazuhiro","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyoshi","family":"Kunitomo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushige","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hijiri","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoaki","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0742-7272","authenticated-orcid":false,"given":"Masaaki","family":"Akai","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Japanese Red Cross Okayama Hospital, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7447-2897","authenticated-orcid":false,"given":"Shoji","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery, Japanese Red Cross Okayama Hospital, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Toji","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Okayama Hospital, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyoshi","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51119","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Yang CW, Che F, Liu XJ, et al. Insight into gastrointestinal heterotopic pancreas: imaging evaluation and differential diagnosis. Insights Imaging 2021; 12: 144.","DOI":"10.1186\/s13244-021-01089-0"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Erkan N, Vardar E, Vardar R. Heterotopic pancreas: report of two cases. JOP 2007; 8: 588\u201391.","DOI":"10.1016\/j.eatbeh.2006.03.002"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Farah A, Mansour S, Khuri S. Gastrointestinal tract heterotopic pancreas: asymptomatic pathology? Gastroenterology Res 2021; 14: 45\u20137.","DOI":"10.14740\/gr1363"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Rezvani M, Menias C, Sandrasegaran K, et al. Heterotopic pancreas: histopathologic features, imaging findings, and complications. Radiographics 2017; 37: 484\u201399.","DOI":"10.1148\/rg.2017160091"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Wla\u017a J, M\u0105dro A, Ka\u017amierak W, et al. Pancreatic and gastric heterotopy in the gastrointestinal tract. Postepy Hig Med Dosw (Online) 2014; 68: 1069\u201375.","DOI":"10.5604\/17322693.1119720"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Kaneko T, Ohara M, Okamura K, et al. Adenocarcinoma arising from an ectopic pancreas in the duodenum: a case report. Surg Case Rep 2019; 5: 126.","DOI":"10.1186\/s40792-019-0684-8"},{"key":"7","unstructured":"7) Guillou L, Nordback P, Gerber C, et al. Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia. Arch Pathol Lab Med 1994; 118: 568\u201371."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Roshe J, Del Buono E, Domenico D, et al. Anaplastic carcinoma arising in ectopic pancreas located in the distal esophagus. J Clin Gastroenterol 1996; 22: 242\u20134.","DOI":"10.1097\/00004836-199604000-00022"},{"key":"9","unstructured":"9) Halkic N, Nordback P. Soft-tissue images. Malignant degeneration of heterotopic pancreas. Can J Surg 2001; 44: 407."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Crighton E, Botha A. Intraductal papillary mucinous neoplasm of the oesophagus: an unusual case of dysphagia. Ann R Coll Surg Engl 2012; 94: e92\u20134.","DOI":"10.1308\/003588412X13171221589090"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Ulrych J, Fryba V, Skalova H, et al. Premalignant and malignant lesions of the heterotopic pancreas in the esophagus: a case report and review of the literature. J Gastrointestin Liver Dis 2015; 24: 235\u20139.","DOI":"10.15403\/jgld.2014.1121.242.uly"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Yang YB, Liu YQ, Dai L, et al. Malignant transformation of heterotopic pancreas as middle esophagus adenocarcinoma-A rare case report and comprehensive literature review. Thorac Cancer 2022; 13: 1083\u20137.","DOI":"10.1111\/1759-7714.14344"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Goto J, Ohashi S, Okamura S, et al. Heterotopic pancreas in the esophagus diagnosed by EUS-guided FNA. Gastrointest Endosc 2005; 62: 812\u20134.","DOI":"10.1016\/j.gie.2005.04.031"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Khalyfa AA, Aslam R, Spyratos T. Heterotopic pancreas in the esophagus: what do we know?-a review of the literature. Gastro Hep Adv 2022; 2: 144\u20136.","DOI":"10.1016\/j.gastha.2022.06.010"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Cazacu IM, Luzuriaga Chavez AA, Nogueras Gonzalez GM, et al. Malignant transformation of ectopic pancreas. Dig Dis Sci 2019; 64: 655\u201368.","DOI":"10.1007\/s10620-018-5366-z"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Matsui M, Goto H, Niwa Y, et al. Preliminary results of fine needle aspiration biopsy histology in upper gastrointestinal submucosal tumors. Endoscopy 1998; 30: 750\u20135.","DOI":"10.1055\/s-2007-1001416"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Osanai M, Miyokawa N, Tamaki T, et al. Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case. Pathol Int 2001; 51: 549\u201354.","DOI":"10.1046\/j.1440-1827.2001.01240.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) La Rosa S, Franzi F, Marchet S, et al. The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. Virchows Arch 2009; 454: 133\u201342.","DOI":"10.1007\/s00428-008-0710-x"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Kim GE, Bae HI, Park HU, et al. Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas. Gastroenterology 2002; 123: 1052\u201360.","DOI":"10.1053\/gast.2002.36018"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yamaoka Y, Yamaguchi T, Kinugasa Y, et al. Adenocarcinoma arising from jejunal ectopic pancreas mimicking peritoneal metastasis from colon cancer: a case report and literature review. Surg Case Rep 2015; 1: 114.","DOI":"10.1186\/s40792-015-0118-1"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med 2013; 369: 1691\u2013703.","DOI":"10.1056\/NEJMoa1304369"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.26-0088\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T04:43:53Z","timestamp":1782535433000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.26-0088\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.70352\/scrj.cr.26-0088","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"cr.26-0088"}}