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Spontaneous regression of cancer: preliminary report. Ann Surg 1956; 144: 366\u201383.","DOI":"10.1097\/00000658-195609000-00007"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Challis GB, Stam HJ. The spontaneous regression of cancer. A review of cases from 1900 to 1987. Acta Oncol 1990; 29: 545\u201350.","DOI":"10.3109\/02841869009090048"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Abdelrazeq AS. Spontaneous regression of colorectal cancer: a review of cases from 1900 to 2005. Int J Colorectal Dis 2007; 22: 727\u201336.","DOI":"10.1007\/s00384-006-0245-z"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Karakuchi N, Shimomura M, Toyota K, et al. Spontaneous regression of transverse colon cancer with high-frequency microsatellite instability: a case report and literature review. World J Surg Oncol 2019; 17: 19.","DOI":"10.1186\/s12957-018-1552-x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Harata S, Takahashi H, Ando N, et al. Spontaneous regression of advanced transverse colon cancer with deficient mismatch repair: a case report. Surg Case Rep 2023; 9: 64.","DOI":"10.1186\/s40792-023-01595-x"},{"key":"6","unstructured":"6) Takeuchi K, Kuwano H, Tsuzuki Y, et al. Clinicopathological characteristics of poorly differentiated adenocarcinoma of the colon and rectum. Hepatogastroenterology 2004; 51: 1698\u2013702."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Scott N, West NP, Cairns A, et al. Is medullary carcinoma of the colon underdiagnosed? An audit of poorly differentiated colorectal carcinomas in a large national health service teaching hospital. Histopathology 2021; 78: 963\u20139.","DOI":"10.1111\/his.14310"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Pyo JS, Sohn JH, Kang G. Medullary carcinoma in the colorectum: a systematic review and meta-analysis. 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Gastrointest Endosc 2022; 96: 321\u20139.e2.","DOI":"10.1016\/j.gie.2022.03.002"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Ohno S, Iwata Y, Mitsutome S, et al. Spontaneous regression of advanced transverse colon cancer: a case report. Surg Case Rep 2025; 11: 24\u20130018.","DOI":"10.70352\/scrj.cr.24-0018"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Ikuta S, Miki C, Ookura E, et al. Spontaneous regression of a metastatic liver tumor: report of a case. Surg Today 2002; 32: 844\u20138.","DOI":"10.1007\/s005950200165"},{"key":"14","unstructured":"14) Bir AS, Fora AA, Levea C, et al. Spontaneous regression of colorectal cancer metastatic to retroperitoneal lymph nodes. Anticancer Res 2009; 29: 465\u20138."},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Sakamoto S, Fu K, Kobayashi O, et al. Spontaneous complete regression of a rectal cancer. 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Mod Pathol 2009; 22: 1186\u201395.","DOI":"10.1038\/modpathol.2009.80"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Waldman AD, Fritz JM, Lenardo MJ. A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nat Rev Immunol 2020; 20: 651\u201368.","DOI":"10.1038\/s41577-020-0306-5"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39) Deschoolmeester V, Baay M, Van Marck E, et al. Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients. BMC Immunol 2010; 11: 19.","DOI":"10.1186\/1471-2172-11-19"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40) Wankhede D, Yuan T, Kloor M, et al. Clinical significance of combined tumour-infiltrating lymphocytes and microsatellite instability status in colorectal cancer: a systematic review and network meta-analysis. 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