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Digestive system tumours: WHO classification of tumours, 5th ed. Lyon: International Agency for Research on Cancer; 2019. p. 328\u2013330."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Demetter P, Mar\u00e9chal R, Puleo F, et al. Undifferentiated pancreatic carcinoma with osteoclast-like giant cells: what do we know so far? Front Oncol 2021; 11: 630086.","DOI":"10.3389\/fonc.2021.630086"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Mylonakis A, Driva TS, Lykoudis P, et al. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas: an individual participant data meta-analysis. Ann Hepatobiliary Pancreat Surg 2024; 28: 125\u201333.","DOI":"10.14701\/ahbps.23-161"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Bergmann F, Esposito I, Michalski CW, et al. Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution. 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Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells localized in the main pancreatic duct without extraductal invasion: a case report and literature review. Cureus 2025; 17: e80592.","DOI":"10.7759\/cureus.80592"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Yonghao O, Li Z, Xiao Y, et al. The survival benefits of chemotherapy for undifferentiated carcinoma with osteoclast-like giant cells of pancreas: a retrospective analysis and individual participant data meta-analysis. Cancer Med 2025; 14: e70894.","DOI":"10.1002\/cam4.70894"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Muraki T, Reid MD, Basturk O, et al. Undifferentiated carcinoma with osteoclastic giant cells of the pancreas: clinicopathologic analysis of 38 cases highlights a more protracted clinical course than currently appreciated. 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Int J Surg Case Rep 2016; 23: 134\u20137.","DOI":"10.1016\/j.ijscr.2016.04.013"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Luchini C, Cros J, Pea A, et al. PD-1, PD-L1, and CD163 in pancreatic undifferentiated carcinoma with osteoclast-like giant cells: expression patterns and clinical implications. Hum Pathol 2018; 81: 157\u201365.","DOI":"10.1016\/j.humpath.2018.07.006"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Hrudka J, Lawrie K, Waldauf P, et al. Negative prognostic impact of PD-L1 expression in tumor cells of undifferentiated (anaplastic) carcinoma with osteoclast-like giant cells of the pancreas: study of 13 cases comparing ductal pancreatic carcinoma and review of the literature. Virchows Arch 2020; 477: 687\u201396.","DOI":"10.1007\/s00428-020-02830-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Obayashi M, Shibasaki Y, Koakutsu T, et al. Pancreatic undifferentiated carcinoma with osteoclast-like giant cells curatively resected after pembrolizumab therapy for lung metastases: a case report. BMC Gastroenterol 2020; 20: 220.","DOI":"10.1186\/s12876-020-01362-4"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Besaw RJ, Terra AR, Malvar GL, et al. Durable response to PD-1 blockade in a patient with metastatic pancreatic undifferentiated carcinoma with osteoclast-like giant cells. 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