{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:14:44Z","timestamp":1792800884634,"version":"4.5.0"},"reference-count":28,"publisher":"Japan Surgical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Surg Case Rep"],"published-print":{"date-parts":[[2026]]},"DOI":"10.70352\/scrj.cr.26-0464","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:13:18Z","timestamp":1790374398000},"page":"n\/a","source":"Crossref","is-referenced-by-count":1,"title":["Pancreatic Cancer after Living-Donor Liver Transplantation: A Case Report of Long-Term Recurrence-Free Survival after Pancreaticoduodenectomy Followed by Adjuvant Chemotherapy"],"prefix":"10.70352","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7255-6640","authenticated-orcid":false,"given":"Naoki","family":"Matsuya","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1512-1687","authenticated-orcid":false,"given":"Yoshinori","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaaki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuji","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihito","family":"Kotera","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Mise","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Fukumura","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Saiura","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary-Pancreatic Surgery, Juntendo University School of Medicine, Juntendo University Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"51119","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Lucey MR, Furuya KN, Foley DP. Liver transplantation. N Engl J Med 2023; 389: 1888\u2013900.","DOI":"10.1056\/NEJMra2200923"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Rana A, Ackah RL, Webb GJ, et al. No gains in long-term survival after liver transplantation over the past three decades. Ann Surg 2019; 269: 20\u20137.","DOI":"10.1097\/SLA.0000000000002650"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Watt KD, Pedersen RA, Kremers WK, et al. Long-term probability of and mortality from de novo malignancy after liver transplantation. Gastroenterology 2009; 137: 2010\u20137.","DOI":"10.1053\/j.gastro.2009.08.070"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Mukthinuthalapati PK, Gotur R, Ghabril M. Incidence, risk factors and outcomes of de novo malignancies post liver transplantation. World J Hepatol 2016; 8: 533\u201344.","DOI":"10.4254\/wjh.v8.i12.533"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Carenco C, Faure S, Herrero A, et al. Incidence of solid organ cancers after liver transplantation: comparison with regional cancer incidence rates and risk factors. Liver Int 2015; 35: 1748\u201355.","DOI":"10.1111\/liv.12758"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hojo M, Morimoto T, Maluccio M, et al. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 1999; 397: 530\u20134.","DOI":"10.1038\/17401"},{"key":"7","unstructured":"7) World Health Organization, International Agency for Research on Cancer. Global Cancer Observatory: Cancer Today. Japan Fact Sheet, GLOBOCAN 2022. 2024. Available from: https:\/\/gco.iarc.who.int\/media\/globocan\/factsheets\/populations\/392-japan-fact-sheet.pdf. Accessed 26 Apr 2026."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA Cancer J Clin 2025; 75: 10\u201345.","DOI":"10.3322\/caac.21871"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Tanaka T, Lynch CF, Yu KJ, et al. Pancreatic cancer among solid organ transplant recipients in the United States. J Cancer Res Clin Oncol 2023; 149: 3325\u201333.","DOI":"10.1007\/s00432-022-04227-3"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Oettle H, Neuhaus P, Hochhaus A, et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA 2013; 310: 1473\u201381.","DOI":"10.1001\/jama.2013.279201"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Uesaka K, Boku N, Fukutomi A, et al. Adjuvant chemotherapy of S-1 versus gemcitabine for resected pancreatic cancer: a phase 3, open-label, randomised, non-inferiority trial (JASPAC 01). Lancet 2016; 388: 248\u201357.","DOI":"10.1016\/S0140-6736(16)30583-9"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Unno M, Motoi F, Matsuyama Y, et al. Neoadjuvant chemotherapy with gemcitabine and S-1 versus upfront surgery for resectable pancreatic cancer: results of the randomized phase II\/III Prep-02\/JSAP05 trial. Ann Surg 2026; 283: 57\u201364.","DOI":"10.1097\/SLA.0000000000006730"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Rauf MA, Ziogas IA, Sealock JM, et al. Pancreatic adenocarcinoma in liver transplant recipients: a case series. Ann Pancreat Cancer 2021; 4: 6.","DOI":"10.21037\/apc-21-4"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Sutcliffe RP, Lam W, O\u2019Sullivan A, et al. Pancreaticoduodenectomy after liver transplantation in patients with primary sclerosing cholangitis complicated by distal pancreatobiliary malignancy. World J Surg 2010; 34: 2128\u201332.","DOI":"10.1007\/s00268-010-0624-z"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Stauffer JA, Steers JL, Bonatti H, et al. Liver transplantation and pancreatic resection: a single-center experience and a review of the literature. Liver Transpl 2009; 15: 1728\u201337.","DOI":"10.1002\/lt.21932"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Mejia J, Sucandy I, Steel J, et al. Indications and outcomes of pancreatic surgery after liver transplantation. Clin Transplant 2014; 28: 330\u20136.","DOI":"10.1111\/ctr.12317"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17) Sugiura K, Oba A, Miyashita M, et al. Surgical technique and feasibility of pancreaticoduodenectomy after surgery for perihilar cholangiocarcinoma. Ann Surg Oncol 2026; 33: 1538\u20139.","DOI":"10.1245\/s10434-025-18571-4"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Blake C, Almerey T, Hyman D, et al. Pancreaticoduodenectomy after liver transplantation: a single-center experience. World J Surg 2023; 47: 1018\u201322.","DOI":"10.1007\/s00268-022-06887-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) de\u2019Angelis N, Esposito F, Memeo R, et al. Emergency abdominal surgery after solid organ transplantation: a systematic review. World J Emerg Surg 2016; 11: 43.","DOI":"10.1186\/s13017-016-0101-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Chen E, Belkaid N, Duvoux C, et al. Clinical outcomes of systemic anticancer therapies in solid cancer patients with liver and kidney transplant: an observational cross-sectional study. ESMO Real World Data Digital Oncol 2025; 10: 100185.","DOI":"10.1016\/j.esmorw.2025.100185"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Krisl JC, Doan VP. Chemotherapy and transplantation: the role of immunosuppression in malignancy and a review of antineoplastic agents in solid organ transplant recipients. Am J Transplant 2017; 17: 1974\u201391.","DOI":"10.1111\/ajt.14238"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Coupier A, Gallien Y, Boillot O, et al. Antineoplastic chemotherapy and immunosuppression in liver transplant recipients: Squaring the circle? Clin Transplant 2023; 37: e14841.","DOI":"10.1111\/ctr.14841"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Maggiore U, Palmisano A, Buti S, et al. Chemotherapy, targeted therapy and immunotherapy: which drugs can be safely used in the solid organ transplant recipients? Transpl Int 2021; 34: 2442\u201358.","DOI":"10.1111\/tri.14115"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) van der Vliet JA, Willems MC, de Man BM, et al. Everolimus interferes with healing of experimental intestinal anastomoses. Transplantation 2006; 82: 1477\u201383.","DOI":"10.1097\/01.tp.0000246078.09845.9c"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Grigg SE, Sarri GL, Gow PJ, et al. Systematic review with meta-analysis: sirolimus- or everolimus-based immunosuppression following liver transplantation for hepatocellular carcinoma. Aliment Pharmacol Ther 2019; 49: 1260\u201373.","DOI":"10.1111\/apt.15253"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Takeda Y, Saiura A, Takahashi Y, et al. Asymptomatic pancreatic cancer: does incidental detection impact long-term outcomes? J Gastrointest Surg 2017; 21: 1287\u201395.","DOI":"10.1007\/s11605-017-3421-2"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27) Singhi AD, Koay EJ, Chari ST, et al. Early detection of pancreatic cancer: opportunities and challenges. Gastroenterology 2019; 156: 2024\u201340.","DOI":"10.1053\/j.gastro.2019.01.259"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Uemura S, Hasegawa Y, Obara H, et al. Potential impact of screening examinations on prognosis of de novo malignancies in adult patients after liver transplantation. Livers 2025; 5: 26.","DOI":"10.3390\/livers5020026"}],"container-title":["Surgical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.26-0464\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:16:05Z","timestamp":1790399765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/scrj\/12\/1\/12_cr.26-0464\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.70352\/scrj.cr.26-0464","relation":{},"ISSN":["2198-7793"],"issn-type":[{"value":"2198-7793","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"cr.26-0464"}}