{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:21:57Z","timestamp":1785435717692,"version":"3.56.0"},"reference-count":260,"publisher":"Rockefeller University Press","issue":"4","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11,3]]},"abstract":"<jats:p>Just as the Phantom orchestrates events from the shadows of the Paris Opera House, innate lymphoid cells (ILC) operate behind the scenes of the immune system, shaping immune responses without the antigen specificity of their T cell counterparts. While more understudied than their better-known T cell counterparts, these enigmatic cells serve as first responders to infection and tissue disruption, playing crucial roles in mucosal immunity and homeostasis\u2014packing an iron-fist punch under a velvet glove. However, in the context of inborn errors of immunity (IEI)\u2014a diverse group of over 500 monogenic disorders affecting immune function\u2014the role of ILC remains largely unmasked. While traditionally overlooked, recent patient studies reveal that ILC dysfunction contributes to disease pathogenesis in at least 19 distinct IEI, raising critical questions: Are ILC indispensable protectors, or do they represent a redundant act within the immune repertoire? How do they respond to standard treatments such as hematopoietic stem cell transplantation (HSCT)? In this review, we unveil the hidden roles of ILC in IEI, analyzing their developmental and functional defects, their role in immune dysregulation, and their therapeutic potential. Much like the Phantom\u2019s elusive presence, ILC may hold the key to understanding immune resilience and designing novel treatments for immunocompromised patients.<\/jats:p>","DOI":"10.70962\/jhi.20250045","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T06:21:33Z","timestamp":1755757293000},"update-policy":"https:\/\/doi.org\/10.70962\/jhi.crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Phantom of the immunologic opera: Unmasking the role of innate lymphoid cells (ILC) in inborn errors of immunity (IEI)"],"prefix":"10.70962","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-0686","authenticated-orcid":true,"given":"Ahmet","family":"Eken","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03wmf1y16","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, University of Colorado Anschutz Medical Campus 1 Department of Immunology and Microbiology, , Aurora, CO,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/047g8vk19","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, Erciyes University 2 Department of Medical Biology, , Kayseri,","place":["Turkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4696-6955","authenticated-orcid":true,"given":"Sara","family":"Johnson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03wmf1y16","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, University of Colorado Anschutz Medical Campus 1 Department of Immunology and Microbiology, , Aurora, CO,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-1685","authenticated-orcid":true,"given":"Serife","family":"Erdem","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/047g8vk19","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, Erciyes University 2 Department of Medical Biology, , Kayseri,","place":["Turkiye"]},{"name":"School of Medicine, Kirsehir Ahi Evran University 3 Department of Immunology, , Kirsehir,","place":["Turkiye"]},{"name":"Genome and Stem Cell Center 4 , Kayseri,","place":["Turkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3969-6597","authenticated-orcid":true,"given":"Elena W.Y.","family":"Hsieh","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03wmf1y16","id-type":"ROR","asserted-by":"publisher"}],"name":"School of Medicine, University of Colorado Anschutz Medical Campus 1 Department of Immunology and Microbiology, , Aurora, CO,","place":["USA"]},{"name":"Children\u2019s Hospital Colorado, University of Colorado Anschutz School of Medicine 5 Department of Pediatrics, Section of Allergy and Immunology, , Aurora, CO,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"291","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"2025091014004123000_bib1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/eji.1830050208","article-title":"\u201cNatural\u201d killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype","volume":"5","author":"Kiessling","year":"1975","journal-title":"Eur. J. Immunol."},{"key":"2025091014004123000_bib2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/eji.1830220207","article-title":"Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3-CD4+ cells","volume":"22","author":"Kelly","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"2025091014004123000_bib3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/s1074-7613(00)80371-4","article-title":"Developing lymph nodes collect CD4+CD3- LTbeta+ cells that can differentiate to APC, NK cells, and follicular cells but not T or B cells","volume":"7","author":"Mebius","year":"1997","journal-title":"Immunity"},{"key":"2025091014004123000_bib4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ni1022","article-title":"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells","volume":"5","author":"Eberl","year":"2004","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib5","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1084\/jem.20091509","article-title":"Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells","volume":"207","author":"Crellin","year":"2010","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib7","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/ni.1668","article-title":"Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells","volume":"10","author":"Cupedo","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib8","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1084\/jem.20051615","article-title":"Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion","volume":"203","author":"Fallon","year":"2006","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/ni.1681","article-title":"Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin","volume":"10","author":"Luci","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib10","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"2025091014004123000_bib11","doi-asserted-by":"publisher","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/ni.1684","article-title":"RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells","volume":"10","author":"Sanos","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib13","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.4049\/jimmunol.0802911","article-title":"Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells","volume":"183","author":"Schmutz","year":"2009","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib14","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ni.2208","article-title":"Transcription factor ROR\u03b1 is critical for nuocyte development","volume":"13","author":"Wong","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib15","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"2025091014004123000_bib16","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells-a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"2025091014004123000_bib17","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1038\/s41590-019-0445-7","article-title":"The transcription factor TCF-1 enforces commitment to the innate lymphoid cell lineage","volume":"20","author":"Harly","year":"2019","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib18","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.immuni.2019.02.022","article-title":"An Id2REP-reporter mouse redefines innate lymphoid cell precursor potentials","volume":"50","author":"Xu","year":"2019","journal-title":"Immunity"},{"key":"2025091014004123000_bib19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nature13047","article-title":"A committed precursor to innate lymphoid cells","volume":"508","author":"Constantinides","year":"2014","journal-title":"Nature"},{"key":"2025091014004123000_bib20","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/s41590-024-01865-2","article-title":"Distinct developmental pathways generate functionally distinct populations of natural killer cells","volume":"25","author":"Ding","year":"2024","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib21","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/s41590-024-01883-0","article-title":"High-dimensional single-cell analysis of human natural killer cell heterogeneity","volume":"25","author":"Rebuffet","year":"2024","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib22","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.immuni.2014.09.005","article-title":"Development, differentiation, and diversity of innate lymphoid cells","volume":"41","author":"Diefenbach","year":"2014","journal-title":"Immunity"},{"key":"2025091014004123000_bib23","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41577-019-0194-8","article-title":"Functional interactions between innate lymphoid cells and adaptive immunity","volume":"19","author":"Sonnenberg","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"2025091014004123000_bib24","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350379","article-title":"Epigenetic regulation of innate lymphoid cells","volume":"54","author":"Sun","year":"2024","journal-title":"Eur. J. Immunol."},{"key":"2025091014004123000_bib25","doi-asserted-by":"publisher","first-page":"2390135","DOI":"10.1080\/19490976.2024.2390135","article-title":"Microbiota and plasticity of antigen-presenting ILC3s: Impact on antitumor immune response","volume":"16","author":"Calabr\u00f2","year":"2024","journal-title":"Gut Microbes"},{"key":"2025091014004123000_bib26","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/s41586-021-04136-4","article-title":"Antigen-presenting innate lymphoid cells orchestrate neuroinflammation","volume":"600","author":"Grigg","year":"2021","journal-title":"Nature"},{"key":"2025091014004123000_bib27","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1126\/science.aaa4812","article-title":"Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4\u207a T cells","volume":"348","author":"Hepworth","year":"2015","journal-title":"Science"},{"key":"2025091014004123000_bib28","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1038\/s41467-020-15612-2","article-title":"Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation","volume":"11","author":"Lehmann","year":"2020","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib29","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.it.2015.01.005","article-title":"Lung ILC2s link innate and adaptive responses in allergic inflammation","volume":"36","author":"Martinez-Gonzalez","year":"2015","journal-title":"Trends Immunol."},{"key":"2025091014004123000_bib30","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1084\/jem.20180871","article-title":"Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria","volume":"216","author":"Melo-Gonzalez","year":"2019","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib31","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.4049\/jimmunol.1300974","article-title":"Type 2 innate lymphoid cells drive CD4+ Th2 cell responses","volume":"192","author":"Mirchandani","year":"2014","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib32","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1038\/s41467-020-15695-x","article-title":"Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs","volume":"11","author":"Rao","year":"2020","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib33","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41423-019-0200-x","article-title":"ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice","volume":"17","author":"Deng","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"2025091014004123000_bib34","doi-asserted-by":"publisher","first-page":"3891","DOI":"10.4049\/jimmunol.174.7.3891","article-title":"Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory","volume":"174","author":"Gaspal","year":"2005","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib35","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/s1074-7613(03)00110-9","article-title":"CD4(+)CD3(\u2212) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells","volume":"18","author":"Kim","year":"2003","journal-title":"Immunity"},{"key":"2025091014004123000_bib36","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.immuni.2015.02.007","article-title":"ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity","volume":"42","author":"Maazi","year":"2015","journal-title":"Immunity"},{"key":"2025091014004123000_bib37","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1600-065X.2011.01057.x","article-title":"OX40 and CD30 signals in CD4(+) T-cell effector and memory function: A distinct role for lymphoid tissue inducer cells in maintaining CD4(+) T-cell memory but not effector function","volume":"244","author":"Withers","year":"2011","journal-title":"Immunol. Rev."},{"key":"2025091014004123000_bib38","doi-asserted-by":"publisher","first-page":"30","DOI":"10.12703\/r\/10-30","article-title":"Recent advances in understanding the Th1\/Th2 effector choice","volume":"10","author":"Butcher","year":"2021","journal-title":"Fac. Rev."},{"key":"2025091014004123000_bib39","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1038\/mi.2016.4","article-title":"IL-4-producing ILC2s are required for the differentiation of T(H)2 cells following Heligmosomoides polygyrus infection","volume":"9","author":"Pelly","year":"2016","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib40","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1111\/all.12446","article-title":"Group 2 innate lymphoid cells and CD4+ T cells cooperate to mediate type 2 immune response in mice","volume":"69","author":"Drake","year":"2014","journal-title":"Allergy"},{"key":"2025091014004123000_bib41","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1126\/science.1243364","article-title":"Nonredundant function of soluble LT\u03b13 produced by innate lymphoid cells in intestinal homeostasis","volume":"342","author":"Kruglov","year":"2013","journal-title":"Science"},{"key":"2025091014004123000_bib42","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.immuni.2008.05.014","article-title":"Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut","volume":"29","author":"Tsuji","year":"2008","journal-title":"Immunity"},{"key":"2025091014004123000_bib43","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.chom.2015.06.011","article-title":"Innate immune defenses mediated by two ILC subsets are critical for protection against acute Clostridium difficile infection","volume":"18","author":"Abt","year":"2015","journal-title":"Cell Host Microbe."},{"key":"2025091014004123000_bib44","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"2025091014004123000_bib45","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nrrheum.2016.218","article-title":"Innate lymphoid cells in autoimmunity: Emerging regulators in rheumatic diseases","volume":"13","author":"Shikhagaie","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"key":"2025091014004123000_bib46","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2017.09.052","article-title":"ILC1 confer early host protection at initial sites of viral infection","volume":"171","author":"Weizman","year":"2017","journal-title":"Cell"},{"key":"2025091014004123000_bib47","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.86689","article-title":"Depletion of major pathogenic cells in asthma by targeting CRTh2","volume":"1","author":"Huang","year":"2016","journal-title":"JCI Insight"},{"key":"2025091014004123000_bib48","doi-asserted-by":"publisher","first-page":"4602","DOI":"10.4049\/jimmunol.1401244","article-title":"IL-22 fate reporter reveals origin and control of IL-22 production in homeostasis and infection","volume":"193","author":"Ahlfors","year":"2014","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib49","doi-asserted-by":"publisher","first-page":"4383","DOI":"10.4049\/jimmunol.1301228","article-title":"TCF-1 controls ILC2 and NKp46+ROR\u03b3t+ innate lymphocyte differentiation and protection in intestinal inflammation","volume":"191","author":"Mielke","year":"2013","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib50","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.10066","article-title":"ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation","volume":"5","author":"Pearson","year":"2016","journal-title":"Elife"},{"key":"2025091014004123000_bib51","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.immuni.2011.11.011","article-title":"The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells","volume":"36","author":"Qiu","year":"2012","journal-title":"Immunity"},{"key":"2025091014004123000_bib52","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/ni.3332","article-title":"Complementarity and redundancy of IL-22-producing innate lymphoid cells","volume":"17","author":"Rankin","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib53","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.immuni.2014.10.007","article-title":"The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells","volume":"41","author":"Satoh-Takayama","year":"2014","journal-title":"Immunity"},{"key":"2025091014004123000_bib54","doi-asserted-by":"publisher","first-page":"4603","DOI":"10.1038\/ncomms5603","article-title":"DOCK8 regulates protective immunity by controlling the function and survival of ROR\u03b3t+ ILCs","volume":"5","author":"Singh","year":"2014","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib55","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1084\/jem.20151403","article-title":"Unique and redundant functions of NKp46+ ILC3s in models of intestinal inflammation","volume":"212","author":"Song","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib56","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.immuni.2010.12.009","article-title":"CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut","volume":"34","author":"Sonnenberg","year":"2011","journal-title":"Immunity"},{"key":"2025091014004123000_bib57","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1073\/pnas.1206587110","article-title":"IL-33 drives biphasic IL-13 production for noncanonical Type 2 immunity against hookworms","volume":"110","author":"Hung","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib58","doi-asserted-by":"publisher","first-page":"3451","DOI":"10.1073\/pnas.1201042109","article-title":"Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice","volume":"109","author":"Yasuda","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.jaci.2014.04.020","article-title":"Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells","volume":"134","author":"Hong","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib60","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"2025091014004123000_bib61","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1126\/science.aac9593","article-title":"Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs","volume":"350","author":"Gasteiger","year":"2015","journal-title":"Science"},{"key":"2025091014004123000_bib62","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/mi.2013.121","article-title":"Conventional CD4+ T cells regulate IL-22-producing intestinal innate lymphoid cells","volume":"7","author":"Korn","year":"2014","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib63","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1016\/j.cell.2017.02.021","article-title":"Systemic human ILC precursors provide a substrate for tissue ILC differentiation","volume":"168","author":"Lim","year":"2017","journal-title":"Cell"},{"key":"2025091014004123000_bib64","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"2025091014004123000_bib65","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/ni.3489","article-title":"Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis","volume":"17","author":"Klose","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib66","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"key":"2025091014004123000_bib67","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ni.2182","article-title":"Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity","volume":"13","author":"Liang","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib68","doi-asserted-by":"publisher","first-page":"10762","DOI":"10.1073\/pnas.1509070112","article-title":"IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions","volume":"112","author":"Monticelli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib69","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1038\/jid.2014.146","article-title":"Composition of innate lymphoid cell subsets in the human skin: Enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients","volume":"134","author":"Teunissen","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"2025091014004123000_bib70","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41385-020-0265-y","article-title":"The role of innate lymphoid cells in response to microbes at mucosal surfaces","volume":"13","author":"Seo","year":"2020","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib71","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1002\/art.39261","article-title":"Brief report: Enrichment of activated group 3 innate lymphoid cells in psoriatic arthritis synovial fluid","volume":"67","author":"Leijten","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"2025091014004123000_bib72","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"2025091014004123000_bib73","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.immuni.2017.05.001","article-title":"Human ILC1: To be or not to be","volume":"46","author":"Bernink","year":"2017","journal-title":"Immunity"},{"key":"2025091014004123000_bib74","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.immuni.2010.10.017","article-title":"Regulated expression of nuclear receptor ROR\u03b3t confers distinct functional fates to NK cell receptor-expressing ROR\u03b3t(+) innate lymphocytes","volume":"33","author":"Vonarbourg","year":"2010","journal-title":"Immunity"},{"key":"2025091014004123000_bib75","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1038\/s41590-019-0425-y","article-title":"Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues","volume":"20","author":"Cella","year":"2019","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib76","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2013.02.010","article-title":"Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-\u03b3-producing cells","volume":"38","author":"Fuchs","year":"2013","journal-title":"Immunity"},{"key":"2025091014004123000_bib77","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.immuni.2013.08.002","article-title":"Group 3 innate lymphoid cells inhibit T-cell-mediated intestinal inflammation through aryl hydrocarbon receptor signaling and regulation of microflora","volume":"39","author":"Qiu","year":"2013","journal-title":"Immunity"},{"key":"2025091014004123000_bib78","doi-asserted-by":"publisher","first-page":"13921","DOI":"10.1073\/pnas.1307321110","article-title":"Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice","volume":"110","author":"Imai","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib79","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1111\/cea.12353","article-title":"Update on innate lymphoid cells in atopic and non-atopic inflammation in the airways and skin","volume":"44","author":"Mj\u00f6sberg","year":"2014","journal-title":"Clin. Exp. Allergy"},{"key":"2025091014004123000_bib80","doi-asserted-by":"publisher","first-page":"10240","DOI":"10.1073\/pnas.1217158110","article-title":"Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells","volume":"110","author":"Klein Wolterink","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib81","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jaut.2017.05.001","article-title":"Innate lymphoid cell-derived cytokines in autoimmune diseases","volume":"83","author":"Li","year":"2017","journal-title":"J. Autoimmun."},{"key":"2025091014004123000_bib82","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s00281-018-0670-4","article-title":"Innate lymphoid cells in autoimmunity and chronic inflammatory diseases","volume":"40","author":"Xiong","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"2025091014004123000_bib83","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1084\/jem.20101712","article-title":"IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease","volume":"208","author":"Geremia","year":"2011","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib84","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1093\/ibd\/izaa316","article-title":"Crohn's disease is associated with activation of circulating innate lymphoid cells","volume":"27","author":"Mazzurana","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"2025091014004123000_bib85","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nature08949","article-title":"Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology","volume":"464","author":"Buonocore","year":"2010","journal-title":"Nature"},{"key":"2025091014004123000_bib86","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/mi.2011.54","article-title":"Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice","volume":"5","author":"Cox","year":"2012","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib87","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/mi.2013.33","article-title":"IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism","volume":"7","author":"Eken","year":"2014","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib88","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.jaci.2018.02.015","article-title":"Innate lymphoid cells 3 induce psoriasis in xenotransplanted healthy human skin","volume":"142","author":"Keren","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib89","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fimmu.2020.00242","article-title":"Innate lymphocytes in psoriasis","volume":"11","author":"Polese","year":"2020","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib90","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1186\/s13075-019-1984-x","article-title":"CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines","volume":"21","author":"Takaki-Kuwahara","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"2025091014004123000_bib91","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/jid.2013.477","article-title":"Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis","volume":"134","author":"Villanova","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"2025091014004123000_bib92","doi-asserted-by":"publisher","first-page":"20411","DOI":"10.1038\/s41598-022-24617-4","article-title":"Mass cytometry reveals cladribine-induced resets among innate lymphoid cells in multiple sclerosis","volume":"12","author":"Aglas-Leitner","year":"2022","journal-title":"Sci. Rep."},{"key":"2025091014004123000_bib93","doi-asserted-by":"publisher","first-page":"657622","DOI":"10.3389\/fimmu.2021.657622","article-title":"ILC3, a central innate immune component of the gut-brain axis in multiple sclerosis","volume":"12","author":"Miljkovi\u0107","year":"2021","journal-title":"Front Immunol."},{"key":"2025091014004123000_bib94","doi-asserted-by":"publisher","first-page":"909275","DOI":"10.3389\/fimmu.2022.909275","article-title":"Innate lymphoid cells - neglected players in multiple sclerosis","volume":"13","author":"Sadeghi Hassanabadi","year":"2022","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib95","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e41678","article-title":"T-bet(+)ILC3 in peripheral blood is increased in the ankylosing spondylitis with high disease activity","volume":"11","author":"Liu","year":"2025","journal-title":"Heliyon"},{"key":"2025091014004123000_bib96","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s11926-019-0834-9","article-title":"ILC3 in axial spondyloarthritis: The gut angle","volume":"21","author":"Mauro","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"2025091014004123000_bib97","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/ni.3078","article-title":"IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells","volume":"16","author":"Huang","year":"2015","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib98","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1126\/science.1222551","article-title":"Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria","volume":"336","author":"Sonnenberg","year":"2012","journal-title":"Science"},{"key":"2025091014004123000_bib99","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1031\/ni.2131","article-title":"Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus","volume":"12","author":"Monticelli","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib100","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/cei\/uxad056","article-title":"Parallel origins and functions of T cells and ILCs","volume":"213","author":"Jan-Abu","year":"2023","journal-title":"Clin. Exp. Immunol."},{"key":"2025091014004123000_bib101","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28075","article-title":"Intravenous immunoglobulin therapy enhances suppressive regulatory T cells and decreases innate lymphoid cells in children with immune thrombocytopenia","volume":"67","author":"Wang","year":"2020","journal-title":"Pediatr. Blood Cancer"},{"key":"2025091014004123000_bib102","article-title":"International Union of Immunological Societies"},{"key":"2025091014004123000_bib104","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1038\/ni.3553","article-title":"Evidence of innate lymphoid cell redundancy in humans","volume":"17","author":"V\u00e9ly","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib115","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adq1697","article-title":"Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature","volume":"10","author":"Bosticardo","year":"2025","journal-title":"Sci. Immunol."},{"key":"2025091014004123000_bib163","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1126\/science.aaa4282","article-title":"IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations","volume":"349","author":"Okada","year":"2015","journal-title":"Science"},{"key":"2025091014004123000_bib164","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aau6759","article-title":"Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23","volume":"3","author":"Mart\u00ednez-Barricarte","year":"2018","journal-title":"Sci. Immunol."},{"key":"2025091014004123000_bib165","doi-asserted-by":"publisher","first-page":"109691","DOI":"10.1016\/j.clim.2023.109691","article-title":"Defective Treg generation and increased type 3 immune response in leukocyte adhesion deficiency 1","volume":"253","author":"Erdem","year":"2023","journal-title":"Clin. Immunol."},{"key":"2025091014004123000_bib130","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s10875-019-00632-5","article-title":"Genetic deficiency and biochemical inhibition of ITK affect human Th17, Treg, and innate lymphoid cells","volume":"39","author":"Eken","year":"2019","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib166","doi-asserted-by":"publisher","DOI":"10.1101\/2022.07.19.500438","article-title":"Group 3 innate Lymphoid cells are regulated by WASP in a microbiota-dependent manner","author":"Biswas","year":"2022","journal-title":"bioRxiv"},{"key":"2025091014004123000_bib144","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1093\/brain\/awy173","article-title":"BCL11B mutations in patients affected by a neurodevelopmental disorder with reduced type 2 innate lymphoid cells","volume":"141","author":"Lessel","year":"2018","journal-title":"Brain."},{"key":"2025091014004123000_bib167","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s10875-024-01777-8","article-title":"DIAPH1-Deficiency is associated with major T, NK and ILC defects in humans","volume":"44","author":"Azizoglu","year":"2024","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib150","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1002\/eji.201746961","article-title":"Reduced numbers of circulating group 2 innate lymphoid cells in patients with common variable immunodeficiency","volume":"47","author":"Geier","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"2025091014004123000_bib258","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/TACG.S18693","article-title":"The genetic basis of severe combined immunodeficiency and its variants.","volume":"5","author":"Tasher","year":"2012","journal-title":"Appl. Clin. Genet."},{"key":"2025091014004123000_bib103","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.3389\/fimmu.2019.02897","article-title":"Interleukin-7 receptor Alpha in innate lymphoid cells: More than a marker","volume":"10","author":"Sheikh","year":"2019","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib105","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1097\/MOP.0000000000001181","article-title":"A great disturbance in the force: IL-2 receptor defects disrupt immune homeostasis","volume":"34","author":"Hernandez","year":"2022","journal-title":"Curr. Opin. Pediatr."},{"key":"2025091014004123000_bib106","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.coi.2021.07.010","article-title":"Clean up by aisle 2: Roles for IL-2 receptors in host defense and tolerance","volume":"72","author":"Hsieh","year":"2021","journal-title":"Curr. Opin. Immunol."},{"key":"2025091014004123000_bib107","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/1346-8138.15054","article-title":"Prominent dermal Langerhans cells in an Omenn syndrome patient with a novel mutation in the IL2RG gene","volume":"46","author":"Ibusuki","year":"2019","journal-title":"J. Dermatol."},{"key":"2025091014004123000_bib108","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13223-018-0317-y","article-title":"IL2RG hypomorphic mutation: Identification of a novel pathogenic mutation in exon 8 and a review of the literature","volume":"15","author":"Lim","year":"2019","journal-title":"Allergy Asthma. Clin. Immunol."},{"key":"2025091014004123000_bib109","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s10875-018-0514-y","article-title":"T+ NK+ IL-2 receptor \u03b3 chain mutation: A challenging diagnosis of Atypical severe combined immunodeficiency","volume":"38","author":"Stepensky","year":"2018","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib110","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/intimm\/12.2.123","article-title":"Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: Comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice","volume":"12","author":"Suzuki","year":"2000","journal-title":"Int. Immunol."},{"key":"2025091014004123000_bib111","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.3390\/ijms25052977","article-title":"Janus kinase 3 (JAK3): A critical conserved node in immunity disrupted in immune cell cancer and immunodeficiency","volume":"25","author":"Liongue","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"2025091014004123000_bib112","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/mi.2017.38","article-title":"Jak3 deficiency blocks innate lymphoid cell development","volume":"11","author":"Robinette","year":"2018","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib113","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.jaci.2012.12.667","article-title":"Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment","volume":"131","author":"Cattaneo","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib114","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s10875-024-01699-5","article-title":"Omenn syndrome in two infants with different hypomorphic variants in Janus kinase 3","volume":"44","author":"Tsilifis","year":"2024","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib116","doi-asserted-by":"publisher","first-page":"747324","DOI":"10.3389\/fimmu.2021.747324","article-title":"Interleukin-7 biology and its effects on immune cells: Mediator of generation, differentiation, survival, and homeostasis","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib117","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1084\/jem.20140145","article-title":"Nfil3 is required for the development of all innate lymphoid cell subsets","volume":"211","author":"Seillet","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib118","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/j.celrep.2015.02.057","article-title":"NFIL3 orchestrates the emergence of common helper innate lymphoid cell precursors","volume":"10","author":"Xu","year":"2015","journal-title":"Cell Rep."},{"key":"2025091014004123000_bib119","doi-asserted-by":"publisher","first-page":"14601","DOI":"10.1038\/ncomms14601","article-title":"IL-15 sustains IL-7R-independent ILC2 and ILC3 development","volume":"8","author":"Robinette","year":"2017","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib120","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.4049\/jimmunol.1501380","article-title":"Flt3 ligand regulates the development of innate lymphoid cells in fetal and adult mice","volume":"196","author":"Baerenwaldt","year":"2016","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib121","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41467-020-14782-3","article-title":"c-FLIP is crucial for IL-7\/IL-15-dependent NKp46(+) ILC development and protection from intestinal inflammation in mice","volume":"11","author":"Bank","year":"2020","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib122","doi-asserted-by":"publisher","first-page":"2777","DOI":"10.4049\/jimmunol.1601711","article-title":"Fate decision between group 3 innate lymphoid and conventional NK cell lineages by Notch signaling in human circulating hematopoietic progenitors","volume":"199","author":"Kyoizumi","year":"2017","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib123","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/all.14081","article-title":"ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients","volume":"75","author":"Eken","year":"2020","journal-title":"Allergy"},{"key":"2025091014004123000_bib124","doi-asserted-by":"publisher","DOI":"10.1101\/2024.04.23.590767","article-title":"RAG suppresses group 2 Innate lymphoid cells","volume-title":"bioRxiv","author":"Ver Heul","year":"2024"},{"key":"2025091014004123000_bib125","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"2025091014004123000_bib126","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1182\/blood.2019000923","article-title":"Immune dysregulation in patients with RAG deficiency and other forms of combined immune deficiency","volume":"135","author":"Delmonte","year":"2020","journal-title":"Blood"},{"key":"2025091014004123000_bib127","doi-asserted-by":"publisher","first-page":"a002287","DOI":"10.1101\/cshperspect.a002287","article-title":"T-cell signaling regulated by the Tec family kinase, Itk","volume":"2","author":"Andreotti","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2025091014004123000_bib128","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s00109-020-01958-z","article-title":"Role of the IL-2 inducible tyrosine kinase ITK and its inhibitors in disease pathogenesis","volume":"98","author":"Lechner","year":"2020","journal-title":"J. Mol. Med."},{"key":"2025091014004123000_bib129","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/s41467-019-08699-9","article-title":"The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine","volume":"10","author":"Cho","year":"2019","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib131","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.4049\/jimmunol.1400930","article-title":"The multifaceted roles of Bcl11b in thymic and peripheral T cells: Impact on immune diseases","volume":"193","author":"Avram","year":"2014","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib132","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.immuni.2015.07.005","article-title":"Transcription factor Bcl11b controls identity and function of mature type 2 innate lymphoid cells","volume":"43","author":"Califano","year":"2015","journal-title":"Immunity"},{"key":"2025091014004123000_bib133","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/s41467-017-00768-1","article-title":"Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes","volume":"8","author":"Kojo","year":"2017","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib134","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1600-065X.2010.00953.x","article-title":"Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity","volume":"238","author":"Liu","year":"2010","journal-title":"Immunol. Rev."},{"key":"2025091014004123000_bib135","doi-asserted-by":"publisher","first-page":"5800","DOI":"10.1073\/pnas.1610617114","article-title":"Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network","volume":"114","author":"Longabaugh","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib136","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1084\/jem.20142224","article-title":"Bcl11b is essential for group 2 innate lymphoid cell development","volume":"212","author":"Walker","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib137","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1084\/jem.20142318","article-title":"The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development","volume":"212","author":"Yu","year":"2015","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib138","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190972","article-title":"Cell type-specific actions of Bcl11b in early T-lineage and group 2 innate lymphoid cells","volume":"217","author":"Hosokawa","year":"2020","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib139","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1188989","article-title":"An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"2025091014004123000_bib140","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.1188063","article-title":"Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"2025091014004123000_bib141","doi-asserted-by":"publisher","first-page":"1146077","DOI":"10.3389\/fimmu.2023.1146077","article-title":"Transcriptional control of ILC identity","volume":"14","author":"Korchagina","year":"2023","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib142","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1056\/NEJMoa1509164","article-title":"Multisystem anomalies in severe combined immunodeficiency with mutant BCL11B","volume":"375","author":"Punwani","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2025091014004123000_bib143","first-page":"325","article-title":"Deletion in the BCL11B gene and intellectual developmental disorder with speech delay, dysmorphic facies, and T-cell abnormalities - a case report","volume":"33","author":"Roa-Bautista","year":"2022","journal-title":"EJIFCC"},{"key":"2025091014004123000_bib146","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1182\/blood-2013-11-536888","article-title":"Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease","volume":"124","author":"Munneke","year":"2014","journal-title":"Blood"},{"key":"2025091014004123000_bib145","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/JLB.5A1019-522RR","article-title":"Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation","volume":"111","author":"Piperoglou","year":"2022","journal-title":"J. Leukoc. Biol."},{"key":"2025091014004123000_bib147","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2018.12.036","article-title":"The cis-regulatory atlas of the mouse immune system","volume":"176","author":"Yoshida","year":"2019","journal-title":"Cell"},{"key":"2025091014004123000_bib148","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-4899-0987-9_24","article-title":"X-linked agammaglobulinemia and Bruton\u2019s tyrosine kinase","volume":"365","author":"Tsukada","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"2025091014004123000_bib149","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-3-319-22714-6_6","article-title":"Novel therapeutic options for X-linked agammaglobulinemia","volume-title":"Agammaglobulinemia","author":"Staal","year":"2015"},{"key":"2025091014004123000_bib151","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10875-017-0444-0","article-title":"Preferential reduction of circulating innate lymphoid cells type 2 in patients with common variable immunodeficiency with secondary complications is part of a broader immune dysregulation","volume":"37","author":"Friedmann","year":"2017","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib152","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1016\/j.jaci.2015.09.013","article-title":"Expansion of inflammatory innate lymphoid cells in patients with common variable immune deficiency","volume":"137","author":"Cols","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib153","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1038\/s12276-023-01022-z","article-title":"Versatile roles of innate lymphoid cells at the mucosal barrier: From homeostasis to pathological inflammation","volume":"55","author":"Ryu","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"2025091014004123000_bib154","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.clim.2017.06.003","article-title":"DOCK8 deficiency: Insights into pathophysiology, clinical features and management","volume":"181","author":"Biggs","year":"2017","journal-title":"Clin. Immunol."},{"key":"2025091014004123000_bib155","doi-asserted-by":"publisher","first-page":"102277","DOI":"10.1016\/j.coi.2022.102277","article-title":"Insights into the pathogenesis of allergic disease from dedicator of cytokinesis 8 deficiency","volume":"80","author":"Su","year":"2023","journal-title":"Curr. Opin. Immunol."},{"key":"2025091014004123000_bib261","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/j.jaci.2016.04.023","article-title":"Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.","volume":"138","author":"Keles","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib156","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/intimm\/dxaa066","article-title":"DOCK8 controls survival of group 3 innate lymphoid cells in the gut through Cdc42 activation","volume":"33","author":"Aihara","year":"2021","journal-title":"Int. Immunol."},{"key":"2025091014004123000_bib157","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbrc.2021.04.094","article-title":"DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells","volume":"559","author":"Matsubara","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2025091014004123000_bib158","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s10875-014-0126-0","article-title":"DOCK8 deficiency: Clinical and immunological phenotype and treatment options - a review of 136 patients","volume":"35","author":"Aydin","year":"2015","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib159","doi-asserted-by":"publisher","first-page":"121","DOI":"10.3233\/DMA-2010-0751","article-title":"Combined immunodeficiency associated with DOCK8 mutations and related immunodeficiencies","volume":"29","author":"Su","year":"2010","journal-title":"Dis. Markers"},{"key":"2025091014004123000_bib160","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1056\/NEJMoa0905506","article-title":"Combined immunodeficiency associated with DOCK8 mutations","volume":"361","author":"Zhang","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2025091014004123000_bib161","doi-asserted-by":"publisher","first-page":"6288","DOI":"10.1182\/blood-2008-12-115253","article-title":"Recent advances in understanding the pathophysiology of Wiskott-Aldrich syndrome","volume":"113","author":"Bosticardo","year":"2009","journal-title":"Blood"},{"key":"2025091014004123000_bib162","doi-asserted-by":"publisher","first-page":"674572","DOI":"10.3389\/fcell.2021.674572","article-title":"Wiskott-aldrich syndrome protein: Roles in signal transduction in T cells","volume":"9","author":"Ngoenkam","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"2025091014004123000_bib168","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.bbamcr.2009.11.006","article-title":"The role of formins in human disease","volume":"1803","author":"DeWard","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"2025091014004123000_bib169","doi-asserted-by":"publisher","first-page":"2554","DOI":"10.3390\/cells10102554","article-title":"Formins in human disease","volume":"10","author":"Labat-de-Hoz","year":"2021","journal-title":"Cells"},{"key":"2025091014004123000_bib170","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.jaci.2020.12.656","article-title":"Loss of DIAPH1 causes SCBMS, combined immunodeficiency, and mitochondrial dysfunction","volume":"148","author":"Kaustio","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib171","doi-asserted-by":"publisher","first-page":"25152","DOI":"10.1074\/jbc.M703243200","article-title":"T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice","volume":"282","author":"Eisenmann","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2025091014004123000_bib172","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay2432","article-title":"mDia1\/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse","volume":"6","author":"Thumkeo","year":"2020","journal-title":"Sci. Adv."},{"key":"2025091014004123000_bib173","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.3390\/ijms23073578","article-title":"Understanding the role of LFA-1 in leukocyte adhesion deficiency type I (LAD I): Moving towards inflammation?","volume":"23","author":"Fekadu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2025091014004123000_bib174","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1056\/NEJMoa1612197","article-title":"Interleukin-12 and interleukin-23 blockade in leukocyte adhesion deficiency type 1","volume":"376","author":"Moutsopoulos","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"2025091014004123000_bib175","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.jaci.2017.03.010","article-title":"\u03b22 integrins rather than \u03b21 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung","volume":"141","author":"Karta","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib176","doi-asserted-by":"publisher","first-page":"542818","DOI":"10.3389\/fimmu.2020.542818","article-title":"Distinct roles of LFA-1 and ICAM-1 on ILC2s control lung infiltration, effector functions, and development of airway hyperreactivity","volume":"11","author":"Hurrell","year":"2020","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib177","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1084\/jem.20172359","article-title":"ICAM-1 controls development and function of ILC2","volume":"215","author":"Lei","year":"2018","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib178","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1084\/jem.20190689","article-title":"A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue","volume":"216","author":"Rana","year":"2019","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib179","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/mi.2016.86","article-title":"ROR\u03b3t, a multitask nuclear receptor at mucosal surfaces","volume":"10","author":"Eberl","year":"2017","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib180","doi-asserted-by":"publisher","first-page":"10132","DOI":"10.1073\/pnas.97.18.10132","article-title":"Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis","volume":"97","author":"Kurebayashi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib181","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1126\/science.288.5475.2369","article-title":"Requirement for RORgamma in thymocyte survival and lymphoid organ development","volume":"288","author":"Sun","year":"2000","journal-title":"Science"},{"key":"2025091014004123000_bib182","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nature09978","article-title":"Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing ROR\u03b3t activity","volume":"472","author":"Huh","year":"2011","journal-title":"Nature"},{"key":"2025091014004123000_bib183","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41467-018-07911-6","article-title":"ROR\u03b3t inhibition selectively targets IL-17 producing iNKT and \u03b3\u03b4-T cells enriched in Spondyloarthritis patients","volume":"10","author":"Venken","year":"2019","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib184","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nm.4046","article-title":"Transient inhibition of ROR-\u03b3t therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells","volume":"22","author":"Withers","year":"2016","journal-title":"Nat. Med."},{"key":"2025091014004123000_bib185","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1146\/annurev-pharmtox-010919-023711","article-title":"(Inverse) agonists of retinoic acid-related orphan receptor \u03b3: Regulation of immune responses, inflammation, and autoimmune disease","volume":"60","author":"Jetten","year":"2020","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2025091014004123000_bib186","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/s0092-8674(00)80240-8","article-title":"The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells","volume":"89","author":"Zheng","year":"1997","journal-title":"Cell"},{"key":"2025091014004123000_bib187","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.immuni.2014.01.012","article-title":"The transcription factor GATA3 is critical for the development of all IL-7R\u03b1-expressing innate lymphoid cells","volume":"40","author":"Yagi","year":"2014","journal-title":"Immunity"},{"key":"2025091014004123000_bib188","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.immuni.2012.06.020","article-title":"The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells","volume":"37","author":"Hoyler","year":"2012","journal-title":"Immunity"},{"key":"2025091014004123000_bib189","doi-asserted-by":"publisher","first-page":"5610","DOI":"10.1038\/s41467-024-49881-y","article-title":"Stage-specific GATA3 induction promotes ILC2 development after lineage commitment","volume":"15","author":"Furuya","year":"2024","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib190","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1007\/pl00000940","article-title":"Transcription factor GATA3 and the human HDR syndrome","volume":"58","author":"Van Esch","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"2025091014004123000_bib191","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/ni.1731","article-title":"The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation","volume":"10","author":"Koch","year":"2009","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib192","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/s0092-8674(00)80702-3","article-title":"A novel transcription factor, T-bet, directs Th1 lineage commitment","volume":"100","author":"Szabo","year":"2000","journal-title":"Cell"},{"key":"2025091014004123000_bib193","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/s1074-7613(04)00076-7","article-title":"T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells","volume":"20","author":"Townsend","year":"2004","journal-title":"Immunity"},{"key":"2025091014004123000_bib194","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1084\/jem.20131560","article-title":"T-bet and Eomes instruct the development of two distinct natural killer cell lineages in the liver and in the bone marrow","volume":"211","author":"Daussy","year":"2014","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib195","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.immuni.2011.11.016","article-title":"The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation","volume":"36","author":"Gordon","year":"2012","journal-title":"Immunity"},{"key":"2025091014004123000_bib196","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/nature11813","article-title":"A T-bet gradient controls the fate and function of CCR6-ROR\u03b3t+ innate lymphoid cells","volume":"494","author":"Klose","year":"2013","journal-title":"Nature"},{"key":"2025091014004123000_bib197","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1016\/j.cell.2020.10.046","article-title":"Human T-bet governs innate and innate-like adaptive IFN-\u03b3 immunity against mycobacteria","volume":"183","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"2025091014004123000_bib198","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/01.MIB.0000442014.52661.20","article-title":"Interleukin 23 in Crohn\u2019s disease","volume":"20","author":"Eken","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"2025091014004123000_bib199","doi-asserted-by":"publisher","first-page":"1331217","DOI":"10.3389\/fimmu.2024.1331217","article-title":"IL-23 past, present, and future: A roadmap to advancing IL-23 science and therapy","volume":"15","author":"Krueger","year":"2024","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib200","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.immuni.2015.12.003","article-title":"Th17 cell pathway in human immunity: Lessons from genetics and therapeutic interventions","volume":"43","author":"Patel","year":"2015","journal-title":"Immunity"},{"key":"2025091014004123000_bib201","doi-asserted-by":"publisher","first-page":"4344","DOI":"10.1038\/s41467-022-32089-3","article-title":"Notch, RORC and IL-23 signals cooperate to promote multi-lineage human innate lymphoid cell differentiation","volume":"13","author":"Croft","year":"2022","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib202","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/mi.2014.77","article-title":"IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology","volume":"8","author":"Chen","year":"2015","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib203","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2015.08.061","article-title":"An IL-23r\/IL-22 circuit regulates epithelial serum amyloid A to promote local effector Th17 responses","volume":"163","author":"Sano","year":"2015","journal-title":"Cell"},{"key":"2025091014004123000_bib204","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025091014004123000_bib205","doi-asserted-by":"publisher","first-page":"9358","DOI":"10.1074\/jbc.C600321200","article-title":"STAT3 regulates cytokine-mediated generation of inflammatory helper T cells","volume":"282","author":"Yang","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2025091014004123000_bib206","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/ni1488","article-title":"IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways","volume":"8","author":"Zhou","year":"2007","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib207","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.immuni.2013.10.021","article-title":"Induction of innate lymphoid cell-derived interleukin-22 by the transcription factor STAT3 mediates protection against intestinal infection","volume":"40","author":"Guo","year":"2014","journal-title":"Immunity"},{"key":"2025091014004123000_bib208","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1038\/s41467-019-09883-7","article-title":"IL-1\u03b2, IL-23, and TGF-\u03b2 drive plasticity of human ILC2s towards IL-17-producing ILCs in nasal inflammation","volume":"10","author":"Golebski","year":"2019","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib209","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/imcb.12209","article-title":"Hyper IgE syndromes: Clinical and molecular characteristics","volume":"97","author":"Al-Shaikhly","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"2025091014004123000_bib210","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202592","article-title":"Human STAT3 variants underlie autosomal dominant hyper-IgE syndrome by negative dominance","volume":"218","author":"Asano","year":"2021","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib211","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10875-015-0187-8","article-title":"The ying and yang of STAT3 in human disease","volume":"35","author":"Vogel","year":"2015","journal-title":"J. Clin. Immunol."},{"key":"2025091014004123000_bib212","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.cell.2021.01.018","article-title":"Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells","volume":"184","author":"Glassman","year":"2021","journal-title":"Cell"},{"key":"2025091014004123000_bib213","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2306761120","article-title":"Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation","volume":"120","author":"Scarno","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025091014004123000_bib214","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20212434","article-title":"Differential IL-12 signaling induces human natural killer cell activating receptor-mediated ligand-specific expansion","volume":"219","author":"Shemesh","year":"2022","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib215","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ni.2366","article-title":"IL-12 family cytokines: Immunological playmakers","volume":"13","author":"Vignali","year":"2012","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib216","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.4049\/jimmunol.1900719","article-title":"STAT4 directs a protective innate lymphoid cell response to gastrointestinal infection","volume":"203","author":"Dulson","year":"2019","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib217","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1002\/eji.201847480","article-title":"NCR(+) ILC3 maintain larger STAT4 reservoir via T-BET to regulate type 1 features upon IL-23 stimulation in mice","volume":"48","author":"Mikami","year":"2018","journal-title":"Eur. J. Immunol."},{"key":"2025091014004123000_bib218","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1056\/NEJMoa2202318","article-title":"Variant STAT4 and response to ruxolitinib in an autoinflammatory syndrome","volume":"388","author":"Baghdassarian","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"2025091014004123000_bib219","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: From bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"2025091014004123000_bib220","doi-asserted-by":"publisher","first-page":"5699","DOI":"10.4049\/jimmunol.168.11.5699","article-title":"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R","volume":"168","author":"Parham","year":"2002","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib221","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1182\/blood-2010-06-291633","article-title":"A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development","volume":"117","author":"Eckelhart","year":"2011","journal-title":"Blood"},{"key":"2025091014004123000_bib222","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1084\/jem.20150907","article-title":"Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells","volume":"214","author":"Villarino","year":"2017","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib223","doi-asserted-by":"publisher","first-page":"11297","DOI":"10.3390\/ijms231911297","article-title":"Genomic mutations of the STAT5 transcription factor are associated with human cancer and immune diseases","volume":"23","author":"Kim","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2025091014004123000_bib224","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41385-020-0320-8","article-title":"The interplay between innate lymphoid cells and T cells","volume":"13","author":"Cherrier","year":"2020","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib225","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.mucimm.2025.01.012","article-title":"There\u2019s no place like home: How local tissue microenvironments shape the function of innate lymphoid cells","volume":"18","author":"Roberts","year":"2025","journal-title":"Mucosal Immunol."},{"key":"2025091014004123000_bib226","doi-asserted-by":"publisher","first-page":"416","DOI":"10.3389\/fimmu.2015.00416","article-title":"Maintenance of immune homeostasis through ILC\/T cell interactions","volume":"6","author":"von Burg","year":"2015","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib227","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4049\/jimmunol.174.1.21","article-title":"Cellular interactions in lymph node development","volume":"174","author":"Cupedo","year":"2005","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib228","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20220275","article-title":"Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency","volume":"220","author":"L\u00e9vy","year":"2023","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib229","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.jaci.2019.06.008","article-title":"Dendritic cell recognition by group 3 innate lymphoid cells through DNAX accessory molecule 1 triggers proinflammatory reciprocal cell activation","volume":"144","author":"Campana","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib230","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.3389\/fimmu.2017.01298","article-title":"Group 3 innate lymphoid cells: Communications hubs of the intestinal immune system","volume":"8","author":"Withers","year":"2017","journal-title":"Front. Immunol."},{"key":"2025091014004123000_bib231","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/ni.3484","article-title":"Innate lymphoid cell function in the context of adaptive immunity","volume":"17","author":"Bando","year":"2016","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib232","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/imr.12705","article-title":"JAK\/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians","volume":"286","author":"Stabile","year":"2018","journal-title":"Immunol. Rev."},{"key":"2025091014004123000_bib233","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/imm.13138","article-title":"The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life","volume":"159","author":"Ganal-Vonarburg","year":"2020","journal-title":"Immunology"},{"key":"2025091014004123000_bib234","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/intimm\/dxac054","article-title":"The thin line between conventional dendritic cells (cDCs) and group 3 innate lymphoid cells (ILC3s) in the gut","volume":"35","author":"Ulezko Antonova","year":"2023","journal-title":"Int. Immunol."},{"key":"2025091014004123000_bib235","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1038\/ni.2002","article-title":"ROR\u03b3t+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota","volume":"12","author":"Sawa","year":"2011","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib236","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.immuni.2010.10.012","article-title":"Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2","volume":"33","author":"Crellin","year":"2010","journal-title":"Immunity"},{"key":"2025091014004123000_bib237","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3390\/pathogens12040518","article-title":"Microbiome and its dysbiosis in inborn errors of immunity","volume":"12","author":"Sharma","year":"2023","journal-title":"Pathogens"},{"key":"2025091014004123000_bib238","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/ni.3809","article-title":"SMAD4 impedes the conversion of NK cells into ILC1-like cells by curtailing non-canonical TGF-\u03b2 signaling","volume":"18","author":"Cortez","year":"2017","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib259","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.cell.2016.04.029","article-title":"Developmental acquisition of regulomes underlies innate lymphoid cell functionality.","volume":"165","author":"Shih","year":"2016","journal-title":"Cell"},{"key":"2025091014004123000_bib239","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/j.clnu.2024.04.008","article-title":"The role of the aryl hydrocarbon receptor (AhR) in modulating intestinal ILC3s to optimise gut pathogen resistance in lupus and benefits of nutritional AhR ligands","volume":"43","author":"Hanlon","year":"2024","journal-title":"Clin. Nutr."},{"key":"2025091014004123000_bib240","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1126\/science.1214914","article-title":"Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles","volume":"334","author":"Kiss","year":"2011","journal-title":"Science"},{"key":"2025091014004123000_bib241","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.immuni.2018.09.015","article-title":"Aryl hydrocarbon receptor signaling cell intrinsically inhibits intestinal group 2 innate lymphoid cell function","volume":"49","author":"Li","year":"2018","journal-title":"Immunity"},{"key":"2025091014004123000_bib242","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1084\/jem.20151448","article-title":"Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection","volume":"213","author":"Wilhelm","year":"2016","journal-title":"J. Exp. Med."},{"key":"2025091014004123000_bib243","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.immuni.2015.06.009","article-title":"Retinoic acid differentially regulates the migration of innate lymphoid cell subsets to the gut","volume":"43","author":"Kim","year":"2015","journal-title":"Immunity"},{"key":"2025091014004123000_bib244","doi-asserted-by":"publisher","first-page":"578489","DOI":"10.1016\/j.jneuroim.2024.578489","article-title":"Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis","volume":"398","author":"\u00d6zko\u015far","year":"2025","journal-title":"J. Neuroimmunol."},{"key":"2025091014004123000_bib245","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.isci.2019.06.026","article-title":"Vitamin D\/vitamin D receptor signaling is required for normal development and function of group 3 innate lymphoid cells in the gut","volume":"17","author":"He","year":"2019","journal-title":"iScience"},{"key":"2025091014004123000_bib246","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jaci.2017.01.045","article-title":"Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells","volume":"141","author":"Konya","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"2025091014004123000_bib247","doi-asserted-by":"publisher","first-page":"521","DOI":"10.4049\/jimmunol.1202924","article-title":"Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection","volume":"190","author":"Gladiator","year":"2013","journal-title":"J. Immunol."},{"key":"2025091014004123000_bib248","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/nature12240","article-title":"Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria","volume":"498","author":"Hepworth","year":"2013","journal-title":"Nature"},{"key":"2025091014004123000_bib249","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/ni.2545","article-title":"The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway","volume":"14","author":"Rankin","year":"2013","journal-title":"Nat. Immunol."},{"key":"2025091014004123000_bib250","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity"},{"key":"2025091014004123000_bib251","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.immuni.2012.08.024","article-title":"Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria","volume":"37","author":"Basu","year":"2012","journal-title":"Immunity"},{"key":"2025091014004123000_bib252","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.immuni.2022.02.003","article-title":"A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts","volume":"55","author":"Zindl","year":"2022","journal-title":"Immunity"},{"key":"2025091014004123000_bib253","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/s41586-022-05395-5","article-title":"Non-redundant functions of group 2 innate lymphoid cells","volume":"611","author":"Jarick","year":"2022","journal-title":"Nature"},{"key":"2025091014004123000_bib254","doi-asserted-by":"publisher","first-page":"10566","DOI":"10.1038\/s41467-024-54780-3","article-title":"Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells","volume":"15","author":"Troch","year":"2024","journal-title":"Nat. Commun."},{"key":"2025091014004123000_bib255","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/s41586-022-05297-6","article-title":"Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces","volume":"611","author":"Tsou","year":"2022","journal-title":"Nature"},{"key":"2025091014004123000_bib256","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.1016\/j.cell.2025.03.020","article-title":"Ror\u03b3t-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens","volume":"188","author":"Rodrigues","year":"2025","journal-title":"Cell"},{"key":"2025091014004123000_bib257","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.127527","article-title":"Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients","volume":"5","author":"Pillay","year":"2019","journal-title":"JCI Insight"}],"container-title":["Journal of Human Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rupress.org\/jhi\/article-pdf\/doi\/10.70962\/jhi.20250045\/1950229\/jhi_20250045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/rupress.org\/jhi\/article-pdf\/doi\/10.70962\/jhi.20250045\/1950229\/jhi_20250045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T18:00:49Z","timestamp":1757527249000},"score":1,"resource":{"primary":{"URL":"https:\/\/rupress.org\/jhi\/article\/1\/4\/e20250045\/278314\/Phantom-of-the-immunologic-opera-Unmasking-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":260,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11,3]]}},"URL":"https:\/\/doi.org\/10.70962\/jhi.20250045","relation":{},"ISSN":["3065-8993"],"issn-type":[{"value":"3065-8993","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"article-number":"e20250045"}}