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Pre-HSCT comorbidities included lung disease (48%), colitis\/fistulizing disease (45%), and liver abscesses (19%). Median HSCT age was 6 years. 10-year overall survival was 95.2%, and event-free survival (events: death, second intervention) was 81%. 13 (33%) cases developed autoimmunity (AI); eight had relapsing or late-onset (&amp;gt;2 years) AI. Organ-specific late effects included lung abnormalities (n = 7), liver dysfunction (n = 7), renal disease (n = 3), and recurrent\/new-onset colitis (n = 3). Endocrine sequelae comprised obesity (n = 15), gonadal dysfunction (n = 9), and short stature (n = 7). Skeletal (n = 6), neurological (n = 6), psychological (n = 19), visual (n = 5), and hearing impairments (n = 4) were noted. Late malignancy was reported in two cases. HSCT offers excellent long-term survival in CGD, but significant late effects underscore the need for extended multidisciplinary follow-up.<\/jats:p>","DOI":"10.70962\/jhi.20250076","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:21:36Z","timestamp":1766042496000},"update-policy":"https:\/\/doi.org\/10.70962\/jhi.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond survival: Multisystem long-term outcomes following HSCT in chronic granulomatous disease"],"prefix":"10.70962","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5578-7002","authenticated-orcid":true,"given":"Valentina","family":"Guarnieri","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03zydm450","id-type":"ROR","asserted-by":"publisher"}],"name":"Great Ormond Street (GOS) Hospital for Children NHS Foundation Trust 1 Infection, Immunity, and Inflammation Department, , GOS Institute of Child Health, and NIHR GOSH 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