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Though diagnostic testing via the dihydrorhodamine assay is widely available, disease recognition can be challenging due to the broad range of initial clinical presentations. Preventative antimicrobial therapy is the backbone of management, while treatment of inflammatory disease remains a challenge. Definitive therapy via hematopoietic stem cell transplantation is increasingly favored for resolution of long-term disease risks, while gene therapy remains a promising but investigational treatment. Here, we present our consensus approach to diagnosis and management of CGD.<\/jats:p>","DOI":"10.70962\/jhi.20250162","type":"journal-article","created":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T07:21:43Z","timestamp":1772868103000},"update-policy":"https:\/\/doi.org\/10.70962\/jhi.crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["How I Treat: Chronic granulomatous disease"],"prefix":"10.70962","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7573-9390","authenticated-orcid":true,"given":"Jennifer W.","family":"Leiding","sequence":"first","affiliation":[{"name":"Johns Hopkins University 1 Division of Allergy & Immunology, , Baltimore, MD,","place":["USA"]},{"id":[{"id":"https:\/\/ror.org\/013x5cp73","id-type":"ROR","asserted-by":"publisher"}],"name":"Cancer and Blood Disorders Institute and Institute for Clinical and Translational Research, Johns Hopkins All Children\u2019s Hospital 2 , St. Petersburg, 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