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A total of 322 patients were included; the M:F ratio was 1.8, and the median ages at disease onset and diagnosis were 6.0 and 20.0 mo, respectively. The most common infections included pneumonia (58.0%), lymphadenitis (49.1%), skin abscesses\/cellulitis (40.7%), and invasive pulmonary aspergillosis (17.7%). The most commonly isolated microorganisms were Staphylococcus spp. (22%), Aspergillus spp. (19.3%), and Pseudomonas spp. (11.2%). The genetic diagnosis was established in 108 (30.4%) patients: AR inheritance in 84.3% and X-linked in 15.7%. The median survival age is 8.5 years, and the estimated 10-year survival rate is 77.3%. CGD represents a significant disease burden in the MENA region, necessitating early intervention with molecular\/genetic testing and HSCT availability.<\/jats:p>","DOI":"10.70962\/jhi.20260014","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:02:23Z","timestamp":1783429343000},"update-policy":"https:\/\/doi.org\/10.70962\/jhi.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic granulomatous disease: A multicenter study from the MENA region"],"prefix":"10.70962","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7232-2629","authenticated-orcid":true,"given":"Salem","family":"Al-Tamemi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wq8zb47","id-type":"ROR","asserted-by":"publisher"}],"name":"Sultan Qaboos University Hospital, University Medical Center, College of Medicine and Health Sciences, Sultan Qaboos University 1 Department of Child Health, , 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