{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:51:38Z","timestamp":1791553898806,"version":"4.3.4"},"reference-count":46,"publisher":"Rockefeller University Press","issue":"6","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["rupress.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11,2]]},"abstract":"<jats:p>Autoantibodies (auto-Abs) neutralizing type I interferons (IFN-I) underlie various life-threatening viral infections, and the prevalence of these auto-Abs rises sharply between 65 and 70 years of age. We investigated the familial aggregation of neutralizing IFN-I auto-Abs by assessing concordance rates in Danish older twins, including 3,270 twins aged 65\u201396 years in a sample comprising 1,318 intact twin pairs (2,636 individuals) and 634 twins from broken twin pairs (634 individuals). Neutralizing IFN-I auto-Abs were detected in 1.5% (50\/3,270) of all twins tested, including 1.4% (37\/2,636) in twins from intact pairs and 2.1% (13\/634) in twins from broken pairs. A total of 50 twins had neutralizing IFN-I auto-Abs, including one concordant monozygotic pair and 35 discordant pairs, yielding a low overall concordance rate. A slight, but nonsignificant, increase in mortality was associated with harboring neutralizing IFN-I auto-Abs. Collectively, these findings do not reveal any familial aggregation of IFN-I auto-Abs, arguing against a strong germline genetic etiology of IFN-I auto-Abs in older adults.<\/jats:p>","DOI":"10.70962\/jhi.20260142","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:21:51Z","timestamp":1789453311000},"update-policy":"https:\/\/doi.org\/10.70962\/jhi.crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Autoantibodies neutralizing type I interferons in older twin pairs: Low concordance"],"prefix":"10.70962","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-149X","authenticated-orcid":true,"given":"Signe Bedsted","family":"Clemmensen","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03yrrjy16","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Southern Denmark 1 Epidemiology, Biostatistics and Biodemography, Department of Public Health, , 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