{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:00:29Z","timestamp":1782493229410,"version":"3.54.5"},"reference-count":20,"publisher":"Korean Cleft Palate-Craniofacial Association","issue":"2","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-acfs.org"],"crossmark-restriction":true},"short-container-title":["Arch Craniofac Surg"],"published-print":{"date-parts":[[2022,4,20]]},"abstract":"<jats:p>Nevus sebaceous of Jadassohn is a congenital cutaneous hamartoma with epidermal, sebaceous, follicular, and apocrine structures that usually appears at birth or in early childhood. It has the potential to generate a variety of secondary neoplasms of different lineages, and the risk increases with patient age. Although multiple neoplasms may occasionally arise within the same lesion, the coexistence of more than five secondary tumors is extremely rare. Here we report a case of seven secondary tumors including syringocystadenoma papilliferum, desmoplastic trichilemmoma, sebaceoma, trichoblastoma, pigmented trichoblastoma, sebaceous adenoma, and tumor of follicular infundibulum arising within a nevus sebaceous. The complete diagnosis relies on the histopathological analysis of multipoint biopsies and delicate pathological sections.<\/jats:p>","DOI":"10.7181\/acfs.2022.00101","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T04:08:35Z","timestamp":1648613315000},"page":"83-88","update-policy":"https:\/\/doi.org\/10.7181\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Development of seven secondary neoplasms in a nevus sebaceous: a case report and literature review"],"prefix":"10.7181","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4701-5376","authenticated-orcid":true,"given":"Yi-Wen","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9269-8201","authenticated-orcid":true,"given":"Jung-Chia","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-8550","authenticated-orcid":true,"given":"Wei-Hsuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4182","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30552.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4132\/koreanjpathol.2013.47.6.569"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/dad.0b013e31814a50c6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/dad.0b013e31817903f5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03151.x"},{"key":"ref6","first-page":"1834","volume-title":"The sebaceous nevus: a nevus with deletions of the PTCH gene","author":"Xin","year":"1999"},{"key":"ref7","first-page":"1269","volume-title":"Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings","author":"Eeles","year":"1993"},{"key":"ref8","first-page":"332","volume-title":"Secondary neoplasms associated with nevus sebaceus of Jadassohn: a study of 707 cases","author":"Idriss","year":"2014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/1066896918781719"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02163.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12489"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12146"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000445822"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.5070\/d3262047411"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199810000-00013"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2017.18.1.46"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01770.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2021.00059"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200004000-00012"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12137"}],"container-title":["Archives of Craniofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-acfs.org\/upload\/pdf\/acfs-2022-00101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-acfs.org\/journal\/view.php?doi=10.7181\/acfs.2022.00101","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-acfs.org\/upload\/pdf\/acfs-2022-00101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T06:23:51Z","timestamp":1651127031000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-acfs.org\/journal\/view.php?doi=10.7181\/acfs.2022.00101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.7181\/acfs.2022.00101","relation":{},"ISSN":["2287-1152","2287-5603"],"issn-type":[{"value":"2287-1152","type":"print"},{"value":"2287-5603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"assertion":[{"value":"2022-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-30","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}