{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:01:33Z","timestamp":1793041293403,"version":"4.5.0"},"reference-count":12,"publisher":"Korean Cleft Palate-Craniofacial Association","issue":"2","license":[{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-acfs.org"],"crossmark-restriction":true},"short-container-title":["Arch Craniofac Surg"],"published-print":{"date-parts":[[2025,4,20]]},"abstract":"<jats:p>Medication-related osteonecrosis of the jaw (MRONJ) is a relatively rare but well-documented complication of bisphosphonate therapy. Bisphosphonates are prescribed to millions of patients for the treatment of osteoporosis, Paget\u2019s disease, multiple myeloma, bone metastases, and other bone-related conditions. These drugs inhibit bone resorption by binding to hydroxyapatite, particularly in areas of active resorption, thereby preventing osteoclasts from attaching to the bone. Long-term bisphosphonate therapy is considered a primary risk factor for MRONJ. Bisphosphonate-induced osteonecrosis typically manifests as exposed alveolar bone, which may occur spontaneously or following invasive dental procedures such as extractions, apicectomies, or implant placement. This case report describes a female who developed osteonecrosis in the maxilla and mandible after undergoing bisphosphonate therapy for multiple myeloma and subsequent tooth extractions.<\/jats:p>","DOI":"10.7181\/acfs.2024.0091","type":"journal-article","created":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T23:48:01Z","timestamp":1745797681000},"page":"70-75","update-policy":"https:\/\/doi.org\/10.7181\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multidisciplinary approach for medication-related osteonecrosis of the jaws: a case report and literature review"],"prefix":"10.7181","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7278-9714","authenticated-orcid":true,"given":"Senthilkumar","family":"Annamalai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1172-8550","authenticated-orcid":true,"given":"Arunkumar","family":"Kamalakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-437X","authenticated-orcid":true,"given":"Balaji","family":"Jayaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-5964","authenticated-orcid":true,"given":"Anushya","family":"Selvakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1799-5514","authenticated-orcid":true,"given":"Harish Suresh","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4182","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.04.027"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1148\/rg.297095050"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0907-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.02.8670"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-019-01211-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3399\/bjgp17x691565"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2008.076349"},{"key":"ref9","first-page":"1134","volume-title":"Bisphosphonate-related osteonecrosis of the jaw in patients with osteoporosis","author":"Heng","year":"2012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/471035"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.a0518"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00323-0"}],"container-title":["Archives of Craniofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-acfs.org\/upload\/pdf\/acfs-2024-0091.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-acfs.org\/journal\/view.php?doi=10.7181\/acfs.2024.0091","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-acfs.org\/upload\/pdf\/acfs-2024-0091.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:29:58Z","timestamp":1746170998000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-acfs.org\/journal\/view.php?doi=10.7181\/acfs.2024.0091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,20]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.7181\/acfs.2024.0091","relation":{},"ISSN":["2287-1152","2287-5603"],"issn-type":[{"value":"2287-1152","type":"print"},{"value":"2287-5603","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,20]]},"assertion":[{"value":"2024-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-20","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-20","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}