{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:41:01Z","timestamp":1782423661247,"version":"3.54.5"},"reference-count":18,"publisher":"Korean Cleft Palate-Craniofacial Association","issue":"1","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-acfs.org"],"crossmark-restriction":true},"short-container-title":["Arch Craniofac Surg"],"published-print":{"date-parts":[[2026,2,20]]},"abstract":"<jats:p>Background: To assess the effectiveness of hyperbaric oxygen therapy (HBOT) as an adjunct to standard treatment in early-stage oral submucous fibrosis (OSMF), focusing on mouth opening, burning sensation, pain, and systemic inflammation.Methods: A randomized comparative study was conducted on early-stage OSMF patients divided into two groups. Group 1 received HBOT along with intralesional triamcinolone, hyaluronidase, and oral antioxidants. Group 2 received only the standard intralesional therapy with antioxidants. Clinical parameters\u2014interincisal distance, burning sensation, and pain\u2014were recorded at baseline, first, and second follow-up. Serum C-reactive protein (CRP) levels were measured pre- and post-treatment. Statistical analysis included unpaired t-tests and chi-square tests.Results: Both groups improved clinically, but Group 1 showed significantly greater reductions in burning sensation (p= 0.020), pain, and CRP levels (p= 0.033). Although intergroup differences in mouth opening were not statistically significant, Group 1 showed greater improvement over time. Fibrotic band distribution remained unchanged in both groups. No complications were reported with HBOT.Conclusion: HBOT provides enhanced symptomatic relief and anti-inflammatory effects in early-stage OSMF when used alongside conventional therapy. While it may not reverse fibrosis, its safety and noninvasive nature support its role in multimodal OSMF management.<\/jats:p>","DOI":"10.7181\/acfs.2025.0039","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:24:27Z","timestamp":1772173467000},"page":"10-17","update-policy":"https:\/\/doi.org\/10.7181\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of hyperbaric oxygen therapy in oral submucous fibrosis: a randomized comparative study from 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