{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T19:37:08Z","timestamp":1775158628251,"version":"3.50.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Although current national data show improved graft and patient survival following lung transplant, the effects of several modifiable preexisting comorbid conditions on health-related quality of life after transplant have not been evaluated. This study examines the effects of 3 comorbid conditions present before lung transplant (reduced bone density, diabetes mellitus, and elevated body mass index) on health-related quality of life after lung transplant. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> The Short Form 36 Health Survey was completed by 92 adult recipients at various times after lung transplant (mean, 41 months; range, 1\u2013127 months). Multiple linear regression models that controlled for underlying disease, chronic rejection, and time after transplant tested the independent effects of the 3 pretransplant conditions on posttransplant health-related quality of life. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The effects of pretransplant reduced bone density and diabetes mellitus were not statistically significant in these models. However, pretransplant body mass index had a significant negative effect (\u03b2 = \u2212.29, P = .007) on posttransplant physical health\u2013related quality of life. Additionally, overweight status and obesity exerted comparable independent negative effects ( P = .01 and P = .03, respectively) on the physical function scale of the Short-Form 36 Health Survey compared with persons who were underweight or normal weight before transplant. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Reevaluation of elevated body mass index before transplant as a risk for reduced physical quality of life after lung transplant should be considered. <\/jats:p><\/jats:sec>","DOI":"10.7182\/pit2012582","type":"journal-article","created":{"date-parts":[[2012,12,14]],"date-time":"2012-12-14T02:04:14Z","timestamp":1355450654000},"page":"363-368","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Negative Effects of Pretransplant Body Mass Index on Physical Health\u2014Related Quality of Life after Lung Transplant"],"prefix":"10.7182","volume":"22","author":[{"given":"Haley M.","family":"Hoy","sequence":"first","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene D.","family":"Feurer","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Alexander","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Loyd","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Wells","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Wright","family":"Pinson","sequence":"additional","affiliation":[{"name":"Vanderbilt Transplant Center, Nashville, Tennessee (HMH, IDF, JL, NW, CWP), University of Alabama, Huntsville (HMH, SA), Vanderbilt University Medical Center, Nashville, Tennessee (IDF, CWP)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,12,1]]},"reference":[{"key":"bibr1-pit2012582","unstructured":"Department of Health and Human Services. Organ Procurement and Transplantation Network and Scientific Registry of Transplant Recipients. http:\/\/www.ustransplant.org\/annualreports\/current\/default.htm. 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