{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:07:03Z","timestamp":1780596423364,"version":"3.54.1"},"reference-count":44,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p> Hyperuricemia is a common comorbid condition experienced by up to 28% of kidney transplant recipients. These patients are at elevated risk of acute flare-ups of gout because of transplant-specific risk factors such as impaired renal function, chronic contributing pharmacotherapy (eg, calcineurin inhibitors, diuretics), and associated comorbid conditions. After transplant, treatment is often complicated by drug-drug interactions, renal impairment, and toxic effects of drugs with the use of first-line recommended agents. A number of therapeutic options remain available for transplant recipients, including dose modifications of historic agents and newer pharmacotherapeutic options. Notably, the Kidney Disease Improving Global Outcomes guidelines address the management of hyperuricemia and gout, but these guidelines were last published in 2009, and new data and treatment options have emerged since then. The management of hyperuricemia and acute and chronic gout is described, including the use of novel agents including urate oxidases, interleukin 1 inhibitors, and human urate transporter 1 inhibitors and alternative immunosuppressive therapy strategies. <\/jats:p>","DOI":"10.7182\/pit2015322","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T21:17:22Z","timestamp":1440623842000},"page":"263-270","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Hyperuricemia and Gout in Solid-Organ Transplant: Update in Pharmacological Management"],"prefix":"10.7182","volume":"25","author":[{"given":"Peter M.","family":"Sullivan","sequence":"first","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York (PMS), Yale University School of Medicine (AW), Yale-New Haven Hospital (EMT), New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asch","family":"William","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York (PMS), Yale University School of Medicine (AW), Yale-New Haven Hospital (EMT), New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric M.","family":"Tichy","sequence":"additional","affiliation":[{"name":"Memorial Sloan-Kettering Cancer Center, New York, New York (PMS), Yale University School of Medicine (AW), Yale-New Haven Hospital (EMT), New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,9,1]]},"reference":[{"issue":"5","key":"bibr1-pit2015322","first-page":"1773","volume":"24","author":"Delaney V","year":"1992","journal-title":"Transplant Proc"},{"key":"bibr2-pit2015322","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0b013e31827d8790"},{"key":"bibr3-pit2015322","first-page":"S102","volume":"9","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group","year":"2009","journal-title":"Am J Transplant"},{"key":"bibr4-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400525"},{"key":"bibr5-pit2015322","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90441-4"},{"key":"bibr6-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"bibr7-pit2015322","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120005370"},{"key":"bibr8-pit2015322","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000188722.84775.af"},{"key":"bibr9-pit2015322","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr10-pit2015322","doi-asserted-by":"publisher","DOI":"10.1186\/ar3272"},{"key":"bibr11-pit2015322","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.3.339"},{"key":"bibr12-pit2015322","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199710150-00027"},{"key":"bibr13-pit2015322","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1990.tb00195.x"},{"key":"bibr14-pit2015322","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(00)00175-3"},{"key":"bibr15-pit2015322","doi-asserted-by":"publisher","DOI":"10.1186\/ar2978"},{"issue":"12","key":"bibr16-pit2015322","first-page":"2429","volume":"31","author":"Borstad GC","year":"2004","journal-title":"J Rheumatol"},{"key":"bibr17-pit2015322","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.11.2467b"},{"issue":"5","key":"bibr18-pit2015322","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1681\/ASN.V115974","volume":"11","author":"Clive DM","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"bibr19-pit2015322","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01368.x"},{"key":"bibr20-pit2015322","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/ard.2009.127621","volume":"70","author":"Perez-Ruiz F","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"bibr21-pit2015322","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1136\/ard.2010.131102","volume":"70","author":"Fleischmann R","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"bibr22-pit2015322","unstructured":"AstraZeneca Announces Top-line Results From the Phase III Programme of Lesinurad in Combination with Xanthine Oxidase Inhibitors in Gout Patients [press release]. August 13, 2014. http:\/\/www.astrazeneca.com\/Media\/Press-releases\/Article\/13082014-astrazeneca-announces-topline-results-from-the-phase. Accessed June 22, 2015."},{"key":"bibr23-pit2015322","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03016.x"},{"key":"bibr24-pit2015322","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05840710"},{"key":"bibr25-pit2015322","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.055251"},{"key":"bibr26-pit2015322","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.09.012"},{"key":"bibr27-pit2015322","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190118"},{"issue":"2","key":"bibr28-pit2015322","first-page":"264","volume":"18","author":"Wallace SL","year":"1991","journal-title":"J Rheumatol"},{"key":"bibr29-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/art.30389"},{"key":"bibr30-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/art.27327"},{"key":"bibr31-pit2015322","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.11.2389"},{"issue":"1","key":"bibr32-pit2015322","first-page":"111","volume":"20","author":"Alloway JA","year":"1993","journal-title":"J Rheumatol"},{"key":"bibr33-pit2015322","doi-asserted-by":"publisher","DOI":"10.1007\/BF00163854"},{"key":"bibr34-pit2015322","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfh629"},{"key":"bibr35-pit2015322","volume-title":"ELITEK","year":"2011"},{"key":"bibr36-pit2015322","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.212"},{"key":"bibr37-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/art.22403"},{"key":"bibr38-pit2015322","doi-asserted-by":"publisher","DOI":"10.2165\/11202830-000000000-00000"},{"key":"bibr39-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"bibr40-pit2015322","volume-title":"Kyrstexxa","year":"2012"},{"key":"bibr41-pit2015322","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"bibr42-pit2015322","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21989"},{"key":"bibr43-pit2015322","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket114"},{"key":"bibr44-pit2015322","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200908"}],"container-title":["Progress in Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.7182\/pit2015322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.7182\/pit2015322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.7182\/pit2015322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T02:10:50Z","timestamp":1738030250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.7182\/pit2015322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.7182\/pit2015322"],"URL":"https:\/\/doi.org\/10.7182\/pit2015322","relation":{},"ISSN":["1526-9248","2164-6708"],"issn-type":[{"value":"1526-9248","type":"print"},{"value":"2164-6708","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9]]}}}