{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:28:15Z","timestamp":1770506895900,"version":"3.49.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Prog Transpl"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p> Evidence regarding the use of bortezomib-containing schemes in primary treatment of antibody-mediated rejection in heart transplant recipients is scarce. This case report presents the clinical experience with upstream use of bortezomib in primary treatment of early antibody-mediated rejection in an adult heart transplant recipient. Two cycles of bortezomib together with methylprednisolone, immunoadsorption, rituximab, and supplementary doses of intravenous immunoglobulin G reversed signs of heart failure, production of donor-specific antibodies, and findings of antibody-mediated rejection in biopsy. This treatment regimen was tolerated with only mild hematologic toxicity and proved to be successful during a 12-month follow-up. Primary treatment with a bortezomib-containing regimen appears to be a new therapeutic option for severe antibody-mediated rejection in heart transplant recipients. However, the efficacy and safety of this treatment need to be tested in prospective trials. <\/jats:p>","DOI":"10.7182\/pit2015934","type":"journal-article","created":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T22:26:36Z","timestamp":1435184796000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Bortezomib-Containing Regimen for Primary Treatment of Early Antibody-Mediated Cardiac Allograft Rejection: A Case Report"],"prefix":"10.7182","volume":"25","author":[{"given":"Tomas","family":"Gazdic","sequence":"first","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Svobodova","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milos","family":"Kubanek","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kment","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libuse","family":"Pagacova","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondrej","family":"Viklicky","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Malek","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Kautzner","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Experimental Medicine, Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"bibr1-pit2015934","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2010.11.003"},{"key":"bibr2-pit2015934","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.502"},{"key":"bibr3-pit2015934","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2011.08.009"},{"key":"bibr4-pit2015934","unstructured":"Eckman PM, Thorsgard M, Maurer D, Kim Y, Alloway RR, Woodle ES. 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