{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:27:50Z","timestamp":1789140470598,"version":"build-2803163510"},"reference-count":46,"publisher":"International Society of Global Health","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Glob Health"],"DOI":"10.7189\/jogh.15.04172","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T19:31:32Z","timestamp":1750361492000},"source":"Crossref","is-referenced-by-count":3,"title":["The mediating role of inflammation-related indicators in the association of remnant cholesterol with gestational diabetes mellitus"],"prefix":"10.7189","volume":"15","author":[{"given":"Lihua","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Healthcare, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics, Gynaecology and Paediatrics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics, Gynaecology and Paediatrics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics, Gynaecology and Paediatrics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics, Gynaecology and Paediatrics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4223","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"key-10.7189\/jogh.15.04172-202506192110-R1","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.cdtm.2016.11.004","article-title":"Diagnosis, prevention and management of gestational diabetes mellitus.","volume":"2","author":"Wang","year":"2016","journal-title":"Chronic Dis Transl Med"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/FM9.0000000000000008","article-title":"Diagnosis of Gestational Diabetes Mellitus in China: Perspective, Progress and Prospects.","volume":"1","author":"Juan","year":"2019","journal-title":"Matern Fetal Med"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R3","doi-asserted-by":"publisher","first-page":"9517","DOI":"10.3390\/ijerph17249517","article-title":"Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China.","volume":"17","author":"Juan","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R4","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1053\/j.semperi.2015.05.002","article-title":"Gestational diabetes: Linking epidemiology, excessive gestational weight gain, adverse pregnancy outcomes, and future metabolic syndrome.","volume":"39","author":"Durnwald","year":"2015","journal-title":"Semin Perinatol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R5","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.2337\/dc20-S002","article-title":"2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020.","volume":"43","author":"American Diabetes Association","year":"2020","journal-title":"Diabetes Care"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R6","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0140-6736(24)00825-0","article-title":"Epidemiology and management of gestational diabetes.","volume":"404","author":"Sweeting","year":"2024","journal-title":"Lancet"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R7","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/jdi.12854","article-title":"Prevalence of gestational diabetes mellitus in mainland China: A systematic review and meta-analysis.","volume":"10","author":"Gao","year":"2019","journal-title":"J Diabetes Investig"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R8","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41572-019-0098-8","article-title":"Gestational diabetes mellitus.","volume":"5","author":"McIntyre","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R9","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.3390\/nu16111577","article-title":"Maternal Hypertriglyceridemia in Gestational Diabetes: A New Risk Factor?","volume":"16","author":"Marques Puga","year":"2024","journal-title":"Nutrients"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R10","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/jp.2016.191","article-title":"The associations between early pregnancy lipid profiles and pregnancy outcomes.","volume":"37","author":"Wang","year":"2017","journal-title":"J Perinatol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12944-021-01565-y","article-title":"Serum lipid levels in relation to clinical outcomes in pregnant women with gestational diabetes mellitus: an observational cohort study.","volume":"20","author":"Li","year":"2021","journal-title":"Lipids Health Dis"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R12","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12933-022-01554-0","article-title":"The role of remnant cholesterol beyond low-density lipoprotein cholesterol in diabetes mellitus.","volume":"21","author":"Hu","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R13","doi-asserted-by":"publisher","first-page":"4324","DOI":"10.1093\/eurheartj\/ehab432","article-title":"Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study.","volume":"42","author":"Quispe","year":"2021","journal-title":"Eur Heart J"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R14","doi-asserted-by":"publisher","first-page":"4735","DOI":"10.2147\/DMSO.S341285","article-title":"Remnant Cholesterol is an Independent Predictor of New-Onset Diabetes: A Single-Center Cohort Study.","volume":"14","author":"Xie","year":"2021","journal-title":"Diabetes Metab Syndr Obes"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R15","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.5551\/jat.53132","article-title":"Association of Small Dense Low-Density Lipoprotein Cholesterol with Stroke Risk, Severity and Prognosis.","volume":"27","author":"Zhou","year":"2020","journal-title":"J Atheroscler Thromb"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R16","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1093\/eurheartj\/ehs431","article-title":"Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction.","volume":"34","author":"J\u00f8rgensen","year":"2013","journal-title":"Eur Heart J"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R17","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0021-9150(02)00057-6","article-title":"Relationship between insulin-resistance and remnant-like particle cholesterol.","volume":"164","author":"Ohnishi","year":"2002","journal-title":"Atherosclerosis"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R18","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12933-021-01348-w","article-title":"Triglyceride-rich lipoprotein and LDL particle subfractions and their association with incident type 2 diabetes: the PREVEND study.","volume":"20","author":"Sokooti","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R19","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/j.1463-1326.2012.01607.x","article-title":"Utility of non-high-density lipoprotein cholesterol in assessing incident type 2 diabetes risk.","volume":"14","author":"Ley","year":"2012","journal-title":"Diabetes Obes Metab"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R20","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1161\/CIRCULATIONAHA.113.003008","article-title":"Elevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation.","volume":"128","author":"Varbo","year":"2013","journal-title":"Circulation"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.atherosclerosis.2003.09.016","article-title":"The close relationship between postprandial remnant metabolism and insulin resistance.","volume":"172","author":"Funada","year":"2004","journal-title":"Atherosclerosis"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R22","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1186\/s12967-023-04322-0","article-title":"Remnant cholesterol, but not other cholesterol parameters, is associated with gestational diabetes mellitus in pregnant women: a prospective cohort study.","volume":"21","author":"Gao","year":"2023","journal-title":"J Transl Med"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R23","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1210\/clinem\/dgad262","article-title":"Remnant Cholesterol Is Associated With Gestational Diabetes Mellitus: A Cohort Study.","volume":"108","author":"Wang","year":"2023","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R24","doi-asserted-by":"publisher","first-page":"e010953","DOI":"10.1161\/CIRCIMAGING.120.010953","article-title":"Remnant Cholesterol and Common Carotid Artery Intima-Media Thickness in Patients With Ischemic Stroke.","volume":"14","author":"Qian","year":"2021","journal-title":"Circ Cardiovasc Imaging"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R25","doi-asserted-by":"publisher","first-page":"676","DOI":"10.2337\/dc10-0719","article-title":"International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.","volume":"33","author":"Metzger","year":"2010","journal-title":"Diabetes Care"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R26","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1111\/1471-0528.17548","article-title":"Combined healthy lifestyle in early pregnancy and risk of gestational diabetes mellitus: A prospective cohort study.","volume":"130","author":"Wu","year":"2023","journal-title":"BJOG"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R27","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12944-024-02230-w","article-title":"Associations of remnant cholesterol in early pregnancy with gestational diabetes mellitus risk: a prospective birth cohort study.","volume":"23","author":"Su","year":"2024","journal-title":"Lipids Health Dis"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R28","doi-asserted-by":"publisher","first-page":"15949","DOI":"10.1038\/s41598-020-73039-7","article-title":"Birth and birth-related obstetrical characteristics in southwestern China associated with the current adjustment of family planning policy: a 7-year retrospective study.","volume":"10","author":"Liu","year":"2020","journal-title":"Sci Rep"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R29","first-page":"5","article-title":"[Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population].","volume":"23","author":"Zhou","year":"2002","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R30","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1037\/1082-989X.7.4.422","article-title":"Mediation in experimental and nonexperimental studies: new procedures and recommendations.","volume":"7","author":"Shrout","year":"2002","journal-title":"Psychol Methods"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1037\/a0031034","article-title":"Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros.","volume":"18","author":"Valeri","year":"2013","journal-title":"Psychol Methods"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R32","doi-asserted-by":"publisher","first-page":"100830","DOI":"10.1016\/j.eclinm.2021.100830","article-title":"Association of maternal lipid profile and gestational diabetes mellitus: A systematic review and meta-analysis of 292 studies and 97,880 women.","volume":"34","author":"Hu","year":"2021","journal-title":"EClinicalMedicine"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R33","doi-asserted-by":"publisher","first-page":"305","DOI":"10.2337\/dc22-1550","article-title":"Remnant Cholesterol Is an Independent Predictor of Type 2 Diabetes: A Nationwide Population-Based Cohort Study.","volume":"46","author":"Huh","year":"2023","journal-title":"Diabetes Care"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R34","doi-asserted-by":"publisher","first-page":"e042821","DOI":"10.1136\/bmjopen-2020-042821","article-title":"Association between dyslipidemia and risk of type 2 diabetes mellitus in middle-aged and older Chinese adults: a secondary analysis of a nationwide cohort.","volume":"11","author":"Peng","year":"2021","journal-title":"BMJ Open"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R35","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/S0168-8278(01)00249-5","article-title":"Hepatic steatosis and very low density lipoprotein secretion: the involvement of apolipoprotein E.","volume":"35","author":"Mensenkamp","year":"2001","journal-title":"J Hepatol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R36","doi-asserted-by":"publisher","first-page":"31","DOI":"10.4103\/jrms.JRMS_472_18","article-title":"Prevalence and predictors of prediabetes and its coexistence with high blood pressure in first-degree relatives of patients with type 2 diabetes: A 9-year cohort study.","volume":"25","author":"Hadi Alijanvand","year":"2020","journal-title":"J Res Med Sci"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R37","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1093\/ajcn\/nqab162","article-title":"Association between maternal plasma ferritin concentration, iron supplement use, and the risk of gestational diabetes: a prospective cohort study.","volume":"114","author":"Zhang","year":"2021","journal-title":"Am J Clin Nutr"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R38","doi-asserted-by":"publisher","first-page":"3518","DOI":"10.1210\/clinem\/dgaa435","article-title":"Pancreatic Steatosis Associates With Impaired Insulin Secretion in Genetically Predisposed Individuals.","volume":"105","author":"Wagner","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R39","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41590-019-0548-1","article-title":"Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation.","volume":"21","author":"Zewinger","year":"2020","journal-title":"Nat Immunol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R40","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41574-019-0286-3","article-title":"The role of macrophages in obesity-associated islet inflammation and \u03b2-cell abnormalities.","volume":"16","author":"Ying","year":"2020","journal-title":"Nat Rev Endocrinol"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R41","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/1476-511X-13-98","article-title":"Atorvastatin helps preserve pancreatic \u03b2 cell function in obese C57BL\/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress.","volume":"13","author":"Chen","year":"2014","journal-title":"Lipids Health Dis"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R42","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s12020-009-9275-y","article-title":"Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells.","volume":"37","author":"Zhao","year":"2010","journal-title":"Endocrine"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R43","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s12192-011-0265-7","article-title":"Cholesterol induces pancreatic \u03b2 cell apoptosis through oxidative stress pathway.","volume":"16","author":"Lu","year":"2011","journal-title":"Cell Stress Chaperones"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R44","doi-asserted-by":"publisher","first-page":"e306","DOI":"10.1016\/S2214-109X(23)00468-0","article-title":"A global analysis of the determinants of maternal health and transitions in maternal mortality.","volume":"12","author":"Souza","year":"2024","journal-title":"Lancet Glob Health"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R45","doi-asserted-by":"publisher","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: a WHO systematic analysis.","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health"},{"key":"key-10.7189\/jogh.15.04172-202506192110-R46","doi-asserted-by":"publisher","first-page":"e002157","DOI":"10.1136\/bmjgh-2019-002157","article-title":"Reducing maternal mortality in China in the era of the two-child policy.","volume":"5","author":"Liu","year":"2020","journal-title":"BMJ Glob Health"}],"container-title":["Journal of Global Health"],"original-title":[],"link":[{"URL":"https:\/\/jogh.org\/2025\/jogh-15-04172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T19:31:32Z","timestamp":1750361492000},"score":1,"resource":{"primary":{"URL":"https:\/\/jogh.org\/2025\/jogh-15-04172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":46,"URL":"https:\/\/doi.org\/10.7189\/jogh.15.04172","relation":{},"ISSN":["2047-2978","2047-2986"],"issn-type":[{"value":"2047-2978","type":"print"},{"value":"2047-2986","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,20]]},"article-number":"04172"}}