{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T14:18:40Z","timestamp":1747232320490,"version":"3.40.5"},"reference-count":0,"publisher":"University of Massachusetts Medical School","issue":"1","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"accepted":{"date-parts":[[2024,1,29]]},"abstract":"<jats:p>Nearly 540 million people world-wide have facial flushing and an increased heart rate after consuming alcohol.&amp;nbsp; Known as the alcohol flushing response, this reaction to alcohol is a result of a genetic variant in an enzyme aldehyde dehydrogenase 2 (ALDH2), known as ALDH2*2.&amp;nbsp; Mainly carried by those of East Asian descent, the genetic variant is likely the most common genetic variant carried in the world.&amp;nbsp; Carrying this ALDH2*2 genetic variant has important health implications with respect cancer risk which is increased when carriers of the ALDH2*2 genetic variant frequently use of alcohol or tobacco products.&amp;nbsp; &amp;nbsp;This comic explains the alcohol flush response and the health risks associated with alcohol and tobacco use for those who carry an ALDH2*2 variant.&amp;nbsp;<\/jats:p>","DOI":"10.7191\/gmr.807","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T17:38:39Z","timestamp":1706549919000},"source":"Crossref","is-referenced-by-count":0,"title":["The Alcohol Flush Response"],"prefix":"10.7191","volume":"4","author":[{"given":"Isabel","family":"Moh","sequence":"first","affiliation":[{"name":"University of Nevada, Reno"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Simon","sequence":"additional","affiliation":[{"name":"Anesthesiology, Perioperative and Pain Medicine, Stanford University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0589-6446","authenticated-orcid":false,"given":"Eric Richard","family":"Gross","sequence":"additional","affiliation":[{"name":"Anesthesiology, Perioperative and Pain Medicine, Stanford University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4192","published-online":{"date-parts":[[2024,2,23]]},"container-title":["Graphic Medicine Review"],"original-title":[],"link":[{"URL":"https:\/\/publishing.escholarship.umassmed.edu\/gmr\/article\/807\/galley\/1254\/download\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T22:36:33Z","timestamp":1708727793000},"score":1,"resource":{"primary":{"URL":"https:\/\/publishing.escholarship.umassmed.edu\/gmr\/article\/id\/807\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,15]]}},"URL":"https:\/\/doi.org\/10.7191\/gmr.807","relation":{},"ISSN":["2993-8252"],"issn-type":[{"type":"electronic","value":"2993-8252"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}