{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:14:26Z","timestamp":1780917266814,"version":"3.54.1"},"reference-count":0,"publisher":"South African Medical Association NPC","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SAMJ"],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:p>We describe a case of prolonged SARS-CoV-2 RNA shedding in an HIV-negative 21-year-old man recovering from abdominal and thoracic trauma. Nasopharyngeal (NP) swabs collected at 12 time points over a 95-day span all tested positive for SARS-CoV-2 by reverse transcription polymerase chain reaction (RT-PCR). Genotyping revealed canonical beta-variant E484K and N501Y mutations at earlier time points. Human rhinovirus, coronavirus NL63 and respiratory syncytial virus B were detected at different time points by RT-PCR. Full blood analysis at time point 9 (day 82) showed leukopenia with lymphocytosis. The patient\u2019s NP swab tested negative for SARS-CoV-2 by RT-PCR 101 days after the first positive test. The prolonged duration of SARS-CoV-2 RNA shedding in the context of trauma presented here is unique and has important implications for COVID-19 diagnosis, management and policy guidelines<\/jats:p>","DOI":"10.7196\/samj.2022.v112i2.16052","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T01:20:12Z","timestamp":1643764812000},"page":"81-85","source":"Crossref","is-referenced-by-count":0,"title":["Prolonged SARS-CoV-2 RNA shedding in a young man recovering from traumatic pneumothorax"],"prefix":"10.7196","volume":"112","author":[{"name":"Ndlovu Laboratories, Elandsdoorn, Limpopo Province, South Africa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5879-8658","authenticated-orcid":false,"given":"C N","family":"Umunnakw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Ndlovu Research Consortium, Elandsdoorn, Limpopo Province, South Africa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z N","family":"Makatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Mdunyelwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Mphanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Nijhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wensing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H A","family":"Tempelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4425","published-online":{"date-parts":[[2022,2,1]]},"container-title":["South African Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:37:31Z","timestamp":1780915051000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.co.za\/doi\/abs\/10.7196\/SAMJ.2022.v112i2.16052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2,1]]},"published-print":{"date-parts":[[2022,2,1]]}},"URL":"https:\/\/doi.org\/10.7196\/samj.2022.v112i2.16052","relation":{},"ISSN":["0256-9574","2078-5135"],"issn-type":[{"value":"0256-9574","type":"print"},{"value":"2078-5135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,1]]}}}