{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:21:54Z","timestamp":1773080514549,"version":"3.50.1"},"reference-count":0,"publisher":"South African Medical Association NPC","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["S Afr Med J"],"abstract":"<jats:p>Calcium channel blocker (CCB) overdose is a life-threatening toxicological emergency associated with vasoplegia and multiorgan failure.We report a case of a 15-year-old male who presented with polypharmacy ingestion and refractory shock despite high-dose insulin\u00a0euglycemic therapy, calcium supplementation and vasopressor support. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO)was initiated 48 hours after ingestion and 40 hours after intensive care unit (ICU) admission. The patient was decannulated after 72 hours on ECMO, and discharged home on day 7 of ICU admission. This case highlights the role of VA-ECMO as a rescue intervention in severeCCB toxicity where conventional therapies fail.<\/jats:p>","DOI":"10.7196\/samj.2025.v115i10.3256","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:16:00Z","timestamp":1762352160000},"page":"e3256","source":"Crossref","is-referenced-by-count":1,"title":["Beyond vasopressor support: VA-ECMO for refractory calcium channel blocker overdose"],"prefix":"10.7196","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0976-4436","authenticated-orcid":false,"given":"J-H","family":"Cheon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-7723","authenticated-orcid":false,"given":"M","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-3611","authenticated-orcid":false,"given":"D","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"4425","published-online":{"date-parts":[[2025,11,4]]},"container-title":["South African Medical Journal"],"original-title":[],"link":[{"URL":"https:\/\/samajournals.co.za\/index.php\/samj\/article\/download\/3256\/1594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/samajournals.co.za\/index.php\/samj\/article\/download\/3256\/1594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:16:02Z","timestamp":1762352162000},"score":1,"resource":{"primary":{"URL":"https:\/\/samajournals.co.za\/index.php\/samj\/article\/view\/3256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":0,"URL":"https:\/\/doi.org\/10.7196\/samj.2025.v115i10.3256","relation":{},"ISSN":["2078-5135","0256-9574"],"issn-type":[{"value":"2078-5135","type":"electronic"},{"value":"0256-9574","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,4]]}}}